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Search Results for " p30 "
Targets Recommended: Apoptosis ALK

32

抑制剂 & 化合物

13

重组蛋白

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Cat. No. Product Name Target Signaling Pathways
T1962 ASP3026

ASP 3026

 Apoptosis; ALK Angiogenesis; Apoptosis; Tyrosine Kinase/Adaptors
ASP3026 是一种选择性的，具有口服活性的间变性淋巴瘤激酶抑制剂，可诱导肿瘤细胞凋亡，可研究非小细胞肺癌。
T6668 SGC-CBP30

Epigenetic Reader Domain; Histone Acetyltransferase Chromatin/Epigenetic
SGC-CBP30 是高选择性CBP/p300溴结构域的有效抑制剂，对CBP 和p300的Kd 值分别为 21 和 32 nM。它强烈减少 Th17 细胞中 IL-17A 的分泌，具有抗炎作用。
T77560 Histone acetyltransferase p300 Inhibitor 4c

Carbonic Anhydrase; AChE Metabolism; Neuroscience
Histone acetyltransferase p300 Inhibitor 4c 是2-氨基噻唑衍生物，Histone acetyltransferase p300 Inhibitor 4c 对 hCA I 、hCA II、AChE 和 BChE 具有抑制作用，Ki 值为 0.008 ± 0.001 、 0.124 ± 0.017、0.129 ± 0.030 和 0.083 ± 0.041 μM。
T7264 CBP/EP300-IN-1

Epigenetic Reader Domain Chromatin/Epigenetic
CBP/EP300-IN-1是一种 CBP/EP300 溴结构域抑制剂。
T12345 CBP/p300-IN-3

P300/CBP-IN-3

 Histone Acetyltransferase Chromatin/Epigenetic
CBP/p300-IN-3 (P300/CBP-IN-3) 是一种组蛋白乙酰转移酶抑制剂。
TNU0864 HUP30

Potassium Channel; Calcium Channel Membrane transporter/Ion channel; Metabolism
HUP30是一种强效的血管舒张剂。HUP30可以刺激可溶性鸟苷酸环化酶，激活 K+离子通道，阻断细胞外 Ca2+的内流。
T36682 USP30 inhibitor 18

DUB Cell Cycle/Checkpoint; DNA Damage/DNA Repair; Ubiquitination
USP30 inhibitor 18 是有效的USP30选择性抑制剂，IC50为 0.02 μM。它增加蛋白质泛素化并加速线粒体自噬。
T13267 USP30 inhibitor 11

USP30-IN-11

 DUB Cell Cycle/Checkpoint; DNA Damage/DNA Repair; Ubiquitination
USP30 inhibitor 11 (USP30-IN-11) 是一个选择性的 USP30 抑制剂(IC50 ： 0.01 µΜ)，抑制 SVA，可用于研究癌症、线粒体功能障碍和帕金森。
T40143 PROTAC CBP/P300 Degrader-1

PROTAC CBP/P300 Degrader-1
PROTAC CBP/P300 Degrader-1 is an effective compound that degrades CBP/P300 in a potent manner. It significantly reduces cell viability in various cancer cell lines.
T41181 iP300v

iP300v is a negative control for iP300w
T10702 CBP/p300-IN-2

CBP/EP300-IN-2

 Epigenetic Reader Domain; c-Myc Cell Cycle/Checkpoint; Chromatin/Epigenetic
CBP/EP300-IN-2 is an inhibitor of CBP/EP300 (IC50s: 1.07 nM and 5.96 nM for CBP/HTRF and Myc).
T13191 TP3011

CH0793011

 Others Others
TP3011 is a potent topoisomerase I inhibitor equipotent as SN38 and is an active metabolite of CH-0793076.
T40144 CBP/p300 ligand 2

CBP/p300 ligand 2 is a selective ligand that binds to the target protein for PROTAC of dCBP-1, a potent and selective heterobifunctional degrader of p300/CBP.
T63767 P300 bromodomain-IN-1

P300 bromodomain-IN-1 是 p300 (EP300) bromodomain 的有效抑制剂 (IC50: 49 nM)。P300 bromodomain-IN-1 能够阻碍 c-Myc 的表达，并诱导 OPM-2 细胞的细胞周期阻滞在 G1/G0 期及诱导其凋亡 (apoptosis)。
T62415 CBP/p300-IN-17

CBP/p300-IN-17 (compound 7) 是一种 EP300/CBP HAT 的有效抑制剂，能够作用于 HAT EP300 (IC50: 0.18 μM) 和 LK2 H3K27 (IC50: 0.69 μM)。
T63565 CBP/p300-IN-19 hydrochloride

CBP/p300-IN-19 hydrochloride 是选择性的、有效的 p300/CBP HAT 抑制剂，能够作用于 p300-HAT (IC50: 1.4 μM)、CBP-HAT (IC50: 2.2 μM)、PCAF (IC50>100 μM)、Myst3 (IC50>100 μM)。CBP/p300-IN-19 hydrochloride 具有抗肿瘤作用。
T12346 CBP/p300-IN-5

P300/CBP-IN-5

 Epigenetic Reader Domain Chromatin/Epigenetic
P300/CBP-IN-5 is a potent inhibitor of p300/CBP histone acetyltransferase (IC50 of 18.8 nM).
T73921 Ep300/CREBBP-IN-2

Ep300/CREBBP-IN-2 (Example 73) 是一种有效的和具有口服活性的Ep300和CREBBP 抑制剂，IC50分别为 0.052 μM 和 0.148 μM。Ep300/CREBBP-IN-2 可用于癌症研究。
T73922 Ep300/CREBBP-IN-3

Ep300/CREBBP-IN-3 (Example 61) 是一种有效的Ep300和CREBBP 抑制剂，IC50分别为 0.056 μM 和 0.095 μM。Ep300/CREBBP-IN-3 可用于癌症研究。
T63110 CBP/p300-IN-15

CBP/p300-IN-15 (compound 13a) 是一种有效的 p300 (IC50: 2.5 nM) 和 CBP (IC50: 28.0 nM) 抑制剂。CBP/p300-IN-15 能够较好的抑制 OVCAR-3 细胞 (EC50: 0.865 μM) 和 A2780 细胞 (EC50: 2.71 μM)。 CBP/p300-IN-15 能够用于研究卵巢癌。
T73920 Ep300/CREBBP-IN-8

Ep300/CREBBP-IN-8 (Example 37) 是一种有效的和具有口服活性的 Ep300和CREBBP 抑制剂，IC50分别为 0.014 μM 和 0.018 μM。Ep300/CREBBP-IN-8 可用于癌症研究。
T72815 CBP/p300-IN-10

CBP/p300-IN-10 是一种高效的组蛋白乙酰转移酶 EP300和CREBBP 的抑制剂，IC50分别为 26 nM 和 39 nM。
T63122 CBP/p300-IN-19

CBP/p300-IN-19 是一种 p300/CBP HAT 的有效抑制剂，能够作用于 p300-HAT (IC50: 1.4 μM)、CBP-HAT (IC50: 2.2 μM)、PCAF (IC50>100 μM)、Myst3 (IC50>100 μM)。CBP/p300-IN-19 具有抗肿瘤活性。
T40142 Thalidomide-NH-CBP/p300 ligand 2

Thalidomide-NH-CBP/p300 ligand 2
Thalidomide-NH-CBP/p300 ligand 2 (P-007) is a PROTAC-based compound designed to degrade CBP and p300, acting as a functional antagonist (WO2020173440).
T62720 CBP/p300-IN-18

CBP/p300-IN-18 (compound 8) 是一种 EP300/CBP HAT 的有效抑制剂，能够作用于 HAT EP300 (IC50: 0.056 μM) 和 LK2 H3K27 (IC50: 0.46 μM)。
T40344 CBP/p300-IN-14

CBP/p300-IN-14
CBP/p300-IN-14, efficiently inhibits CBP/EP300 (lysine acetyltransferase) with an IC50 value of 3.3 nM.
T39826 CBP/p300-IN-8

CBP/p300-IN-8
CBP/p300-IN-8 is a potent inhibitor of the CBP/P300 family of bromodomains . CBP/p300-IN-8 inhibits CBP ( IC 50 =0.01-0.1 μΜ) and BRD4 ( IC 50 =1-1000 μΜ) activity.
T73923 Ep300/CREBBP-IN-4

Ep300/CREBBP-IN-4 (Example 56) 是一种有效的Ep300和CREBBP 抑制剂，IC50分别为 0.024 μM 和 0.064 μM。Ep300/CREBBP-IN-4 可用于癌症研究。
T79395 CBP/p300-IN-21

Epigenetic Reader Domain Chromatin/Epigenetic
CBP/p300-IN-21 (Compound 5d) 作为一种选择性CBP/p300抑制剂，展现出对p300和CBP具有差异性的IC50值，分别为0.07 μM和1.755 μM。该化合物能有效降低H3K18Ac的水平，并抑制小鼠4T1肿瘤的生长。
T28439 PP30

PP 30,PP-30
PP30 is an inhibitor of mTORC1 and mTORC2. It is selective within the PI3K family, inhibiting other PI3Ks only at high concentrations.
T62700 CBP/p300-IN-16

CBP/p300-IN-16 (compound 1) 是一种 EP300/CBP HAT 的有效抑制剂，作用于 HAT EP300 (IC50: 0.61 μM) 和 LK2 H3K27 (IC50: 2.24 μM)。
T23489 UBP301

UBP 301

 Others Others
UBP301 is a kainate receptor antagonist.

化合物

ASP3026
Cat.No: T1962
Synonym: ASP 3026
Target: Apoptosis, ALK
SGC-CBP30
Cat.No: T6668
Synonym:
Target: Epigenetic Reader Domain, Histone Acetyltransferase
Histone acetyltransferase p300 Inhibitor 4c
Cat.No: T77560
Synonym:
Target: Carbonic Anhydrase, AChE
CBP/EP300-IN-1
Cat.No: T7264
Synonym:
Target: Epigenetic Reader Domain
CBP/p300-IN-3
Cat.No: T12345
Synonym: P300/CBP-IN-3
Target: Histone Acetyltransferase
HUP30
Cat.No: TNU0864
Synonym:
Target: Potassium Channel, Calcium Channel
USP30 inhibitor 18
Cat.No: T36682
Synonym:
Target: DUB
USP30 inhibitor 11
Cat.No: T13267
Synonym: USP30-IN-11
Target: DUB
PROTAC CBP/P300 Degrader-1
Cat.No: T40143
Synonym: PROTAC CBP/P300 Degrader-1
Target:
iP300v
Cat.No: T41181
Synonym:
Target:
CBP/p300-IN-2
Cat.No: T10702
Synonym: CBP/EP300-IN-2
Target: Epigenetic Reader Domain, c-Myc
TP3011
Cat.No: T13191
Synonym: CH0793011
Target: Others
CBP/p300 ligand 2
Cat.No: T40144
Synonym:
Target:
P300 bromodomain-IN-1
Cat.No: T63767
Synonym:
Target:
CBP/p300-IN-17
Cat.No: T62415
Synonym:
Target:
CBP/p300-IN-19 hydrochloride
Cat.No: T63565
Synonym:
Target:
CBP/p300-IN-5
Cat.No: T12346
Synonym: P300/CBP-IN-5
Target: Epigenetic Reader Domain
Ep300/CREBBP-IN-2
Cat.No: T73921
Synonym:
Target:
Ep300/CREBBP-IN-3
Cat.No: T73922
Synonym:
Target:
CBP/p300-IN-15
Cat.No: T63110
Synonym:
Target:
Ep300/CREBBP-IN-8
Cat.No: T73920
Synonym:
Target:
CBP/p300-IN-10
Cat.No: T72815
Synonym:
Target:
CBP/p300-IN-19
Cat.No: T63122
Synonym:
Target:
Thalidomide-NH-CBP/p300 ligand 2
Cat.No: T40142
Synonym: Thalidomide-NH-CBP/p300 ligand 2
Target:
CBP/p300-IN-18
Cat.No: T62720
Synonym:
Target:
CBP/p300-IN-14
Cat.No: T40344
Synonym: CBP/p300-IN-14
Target:
CBP/p300-IN-8
Cat.No: T39826
Synonym: CBP/p300-IN-8
Target:
Ep300/CREBBP-IN-4
Cat.No: T73923
Synonym:
Target:
CBP/p300-IN-21
Cat.No: T79395
Synonym:
Target: Epigenetic Reader Domain
PP30
Cat.No: T28439
Synonym: PP 30,PP-30
Target:
CBP/p300-IN-16
Cat.No: T62700
Synonym:
Target:
UBP301
Cat.No: T23489
Synonym: UBP 301
Target: Others
Species：
Human (6)
ASFV (1)
Cynomolgus,Rhesus (1)
MARV (1)
Mouse (1)
Mycoplasma pneumoniae (1)
Rat (1)
ZEBOV (1)
Expression System：
HEK293 Cells (8)
E. coli (4)
Baculovirus Insect Cells (1)
Tag：
C-His (3)
C-His-Avi (2)
C-hFc (2)
N-6xHis (2)
N-10xHis, C-Myc (1)
N-6xHis-GST (1)
N-SUMO (1)
N-hFc (1)
Cat. No. Product Name Species Expression System
TMPH-00033 ASFV (strain Ba71V) p30 Protein (His)

Ba71V-93,Phosphoprotein p30,p30,CP204L,Pho...

 ASFV E. coli
Modifies the subcellular distribution of heterogeneous nuclear ribonucleoprotein K (HNRNPK) and may contribute to modulate HNRNPK functions related to processing and export of mRNAs during ASFV infection.
TMPY-02590 HMGB1 Protein, Mouse, Recombinant (hFc)

HMG-1,SBP-1,high mobility group box 1,p30,Hmg1,DEF,...

 Mouse HEK293 Cells
HMGB1 Protein, Mouse, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 53.3 kDa and the accession number is P63158.
TMPJ-00083 NCR3 Protein, Human, Recombinant (hFc)

Activating Natural Killer Receptor p30,CD337,NK...

 Human HEK293 Cells
Natural Cytotoxicity Triggering Receptor 3 (NCR3) along with NKp44 and NKp46 constitute a group of receptors termed “Natural Cytotoxicity Receptors”. They play a major role in triggering NK-mediated killing of most tumor cells lines. NKp30 is a type I transmembrane protein having a single extracellular V-like immunoglobulin domain. NKp30 is selectively expressed both in resting and activated human NK cells. In addition, NKp30 is also involved in NK-mediated induction of dendritic cell (DC) matur...
TMPH-03031 P30 adhesin Protein, Mycoplasma pneumoniae, Recombinant (GST & His)

Mycoplasma pneumoniae E. coli
Adhesin necessary for successful cytadherence and virulence. P30 adhesin Protein, Mycoplasma pneumoniae, Recombinant (GST & His) is expressed in E. coli expression system with N-6xHis-GST tag. The predicted molecular weight is 49.6 kDa and the accession number is P75330.
TMPY-04616 NKp30/NCR3 Protein, Cynomolgus, Rhesus, Recombinant (His)

natural cytotoxicity triggering receptor 3

 Cynomolgus,Rhesus HEK293 Cells
NKp30/NCR3 Protein, Cynomolgus, Rhesus, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 14.3 kDa and the accession number is XP_005553604.1.
TMPY-01145 NKp30/NCR3 Protein, Human, Recombinant (His)

NCR3,natural cytotoxicity triggering receptor 3,CD337,1C7,DA...

 Human HEK293 Cells
NKp30/NCR3 Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 14.4 kDa and the accession number is O14931-1.
TMPK-00091 NKp30/NCR3 Protein, Human, Recombinant (His & Avi), Biotinylated

1C7,LY117,CD337,NKp30,MALS,NCR3

 Human HEK293 Cells
NKp30, along with NKp44 and NKp46, constitute a group of receptors termed "Natural Cytotoxicity Receptors". These receptors play a major role in triggering NK-mediated killing of most tumor cells lines.NKp30 stimulates NK cells cytotoxicity toward neighboring cells producing these ligands. It controls, for instance, NK cells cytotoxicity against tumor cells.
TMPK-00090 NKp30/NCR3 Protein, Human, Recombinant (His & Avi)

NKp30,1C7,MALS,CD337,LY117,NCR3

 Human HEK293 Cells
NKp30, along with NKp44 and NKp46, constitute a group of receptors termed "Natural Cytotoxicity Receptors". These receptors play a major role in triggering NK-mediated killing of most tumor cells lines.NKp30 stimulates NK cells cytotoxicity toward neighboring cells producing these ligands. It controls, for instance, NK cells cytotoxicity against tumor cells. Engagement of NCR3 by BAG6 also promotes myeloid dendritic cells (DC) maturation, both through killing DCs that did not acquire a mature ph...
TMPH-03729 Zaire ebolavirus (strain Kikwit-95) VP30 Protein (His)

ZEBOV E. coli
Multifunctional protein that acts as a viral transcriptional activator. Promotes read-through of an RNA hairpin in the NP open reading frame to enhance viral transcription. Mechanistically, nonphosphorylated VP30 hexamers form a ternary complex with the viral leader RNA. Clamps the RNA template and the complex VP35-polymerase L together, thereby increasing the polymerase affinity for the RNA template to increase transcription initiation despite the presence of RNA secondary structures. Assists a...
TMPY-00334 NKp30/NCR3 Protein, Rat, Recombinant (His)

natural cytotoxicity triggering receptor 3,1c7

 Rat HEK293 Cells
NKp30/NCR3 Protein, Rat, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 15.2 kDa and the accession number is CAD23066.1.
TMPH-02385 Lake Victoria marburgvirus (MARV) (strain Musoke-80) VP30 Protein (His & Myc)

MARV E. coli
Acts as a transcription anti-termination factor immediately after transcription initiation, but does not affect transcription elongation. This function has been found to be dependent on the formation of an RNA secondary structure at the transcription start site of the first gene.
TMPY-05383 NKp30/NCR3 Protein, Human, Recombinant (hFc)

DAAP-90L16.3,natural cytotoxicity triggering receptor 3,NCR3...

 Human HEK293 Cells
NKp30/NCR3 Protein, Human, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 39.6 kDa and the accession number is O14931-3.
TMPY-03288 USP30 Protein, Human, Recombinant (SUMO)

ubiquitin specific peptidase 30

 Human Baculovirus Insect Cells
Ubiquitin specific peptidase 30, also known as USP30, is a deubiquitinating enzyme that is embedded in the mitochondrial outer membrane. Depletion of USP30 expression by RNA interference induced elongated and interconnected mitochondria, depending on the activities of the mitochondrial fusion factors mitofusins, without changing the expression levels of the key regulators for mitochondrial dynamics. Mitochondria were rescued from this abnormal phenotype by ectopic expression of USP30 in a manner...

重组蛋白

ASFV (strain Ba71V) p30 Protein (His)
Cat.No: TMPH-00033
Species: ASFV
Expression System: E. coli
HMGB1 Protein, Mouse, Recombinant (hFc)
Cat.No: TMPY-02590
Species: Mouse
Expression System: HEK293 Cells
NCR3 Protein, Human, Recombinant (hFc)
Cat.No: TMPJ-00083
Species: Human
Expression System: HEK293 Cells
P30 adhesin Protein, Mycoplasma pneumoniae, Recombinant (GST & His)
Cat.No: TMPH-03031
Species: Mycoplasma pneumoniae
Expression System: E. coli
NKp30/NCR3 Protein, Cynomolgus, Rhesus, Recombinant (His)
Cat.No: TMPY-04616
Species: Cynomolgus,Rhesus
Expression System: HEK293 Cells
NKp30/NCR3 Protein, Human, Recombinant (His)
Cat.No: TMPY-01145
Species: Human
Expression System: HEK293 Cells
NKp30/NCR3 Protein, Human, Recombinant (His & Avi), Biotinylated
Cat.No: TMPK-00091
Species: Human
Expression System: HEK293 Cells
NKp30/NCR3 Protein, Human, Recombinant (His & Avi)
Cat.No: TMPK-00090
Species: Human
Expression System: HEK293 Cells
Zaire ebolavirus (strain Kikwit-95) VP30 Protein (His)
Cat.No: TMPH-03729
Species: ZEBOV
Expression System: E. coli
NKp30/NCR3 Protein, Rat, Recombinant (His)
Cat.No: TMPY-00334
Species: Rat
Expression System: HEK293 Cells
Lake Victoria marburgvirus (MARV) (strain Musoke-80) VP30 Protein (His & Myc)
Cat.No: TMPH-02385
Species: MARV
Expression System: E. coli
NKp30/NCR3 Protein, Human, Recombinant (hFc)
Cat.No: TMPY-05383
Species: Human
Expression System: HEK293 Cells
USP30 Protein, Human, Recombinant (SUMO)
Cat.No: TMPY-03288
Species: Human
Expression System: Baculovirus Insect Cells
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