Pt(IV)-M13 is a platinum (IV) prodrug conjugated with a perfluoroaryl macrocyclic peptide, capable of crossing the blood-brain barrier. It exhibits cytotoxicity towards glioblastoma stem cells and enhances platinum uptake in the brain, making it a valuable tool for glioblastoma research.

Pt(IV)-M13（1-30 μM；80 小时）对G9神经球的IC₅₀约为5 μM，与顺铂相似。

Pt(IV)-M13（2.5 mg/kg；尾静脉注射；单剂量）在小鼠中能显著提高大脑中的铂含量，与顺铂相比增加了15倍。