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33

抑制剂 & 化合物

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天然产物

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Cat. No.	Product Name	Target	Signaling Pathways
T16335	Nonaethylene glycol monododecyl ether Nonaoxyethylene monododecyl ether,Polidocanol,聚醚醇	Others	Others
	Nonaethylene glycol monododecyl ether (Polidocanol) 是一种非离子表面活性剂和聚乙二醇清洁剂，可用于蛋白质分离和纯化，以及用于形成初始聚结的 O/W 乳剂液滴。
T0765	Fomepizole Antizol-Vet,4-甲基吡唑,甲吡唑,4-Methylpyrazole,Antizol	P450; CAT; AChR	Metabolism; Neuroscience; oxidation-reduction
	Fomepizole (4-Methylpyrazole) 是细胞色素 P450 (CYP2E1) 抑制剂。它是乙醇脱氢酶 (alcohol dehydrogenase) 竞争性抑制剂。它能够阻断甲醇和乙二醇进一步转化为有毒代谢产物。它具有成为乙二醇或甲醇中毒的解毒剂的潜力。
T2283	PX-12 2-[(1-甲基丙基)二硫代]-1H-咪唑,IV-2,PX12	Thioredoxin	Metabolism
	PX-12 (PX12) 是一种可逆的硫氧还蛋白-1(Trx-1)抑制剂，能够抑制 MCF-7 细胞(IC50:1.9 μM)和HT-29 细胞(IC50:2.9 μM)的生长。
T28823	SNAP-7941 SNAP7941
	SNAP-7941 is a selective antagonist of the melanin concentrating hormone receptor MCH1 with promising anxiolytic, antidepressant and anorectic effects in initial animal studies.
T5189L	Omadacycline mesylate PTK 0796,PTK-0796,PTK0796
	Omadacycline is an aminomethylcycline antibiotic. Omadacycline demonstrated net cidal activity in relation to the initial burden against four strains of Streptococcus pneumoniae.
T36686	Ac-Arg-Gly-Lys(Ac)-AMC
	Ac-RGK(Ac)-AMC, fluorogenic substrate for assaying histone deacetylase (HDAC) activity in a two-step enzymatic reaction. The assay consists of the initial lysine deacetylation by HDAC followed by the release of the fluorescent group by trypsin.
T39054	Furosine dihydrochloride
	Furosine dihydrochloride, an amino acid derivative, is a significant biochemical indicator of initial Maillard reactions. The compound is strongly associated with various diseases, including diabetes.
T23654	Afeletecan free base BAY 56-3722,BAY56-3722,BAY-563722,Afeletecan
	Afeletecan is a water-soluble camptothecin derivative. Afeletecan stabilizes the topoisomerase I-DNA covalent complex and forms an enzyme-drug-DNA ternary complex. Both the initial cleavage reaction and religation steps are inhibited and subsequent collis
T15499	HOOCCH2O-PEG4-CH2COOH	Others	Others
	HOOCCH2O-PEG4-CH2COOH (compound 5), is a symmetric polyethylene glycol (PEG) linker. It is primarily utilized in the synthesis of the initial Homo-PROTAC[1] compound.
T40932	Benzylacyclouridine 5-Benzylacyclouridine,BAU
	Benzylacyclouridine (BAU) is a powerful and selective inhibitor of uridine phosphorylase, the initial enzyme involved in uridine catabolism. Additionally, it can regulate the cytotoxic adverse effects of 5-fluorouracil (5-FU) and its derivatives.
T76064	Beta-defensin 103 isoform X1, pig
	Beta-defensin 103 isoform X1, pig 是一种抗菌肽、在多种生物体内被发现，参与了先天性免疫防线。
T73216	Gepefrine
	Gepefrine为具口服活性的升压剂及拟交感神经作用剂，能有效改善动脉压早期直立性失调。
T70316	AZD6642
	AZD6642 is a potential and selective 5-Lipoxygenase activating Protein (FLAP) inhibitor. AZD6642 shows high specific potency and low lipophilicity resulting in a selective and metabolically stable profile. Based on initial PK/PD relations a low dose to human was predicted.
T69429	Y27632 HCl hydrate
	Y27632 is a selective ROCK inhibitor, which inhibits ET-1-induced increases in natriuretic peptide production, cell size, protein synthesis, and myofibrillar organization. Y27632 prevents dimethylnitrosamine-induced hepatic fibrosis in rats, increases apoptosis and disrupts the actin cortical mat in embryonic avian corneal epithelium, affects initial heart myofibrillogenesis in cultured chick blastoderm, promotes the proliferation and cell cycle progression of cultured astrocyte from spinal cord...
T81413	pppApG
	pppApG是vRNA（病毒RNA）及cRNA（互补RNA）合成的初始产物，常用于流感病毒相关研究。
T37990	15-keto Prostaglandin F1α 15-keto Prostaglandin F1α
	15-keto PGF1α is the initial metabolite of PGF1α via 15-hydroxy PGDH. In mammals, oxidation of C-15 markedly attenuates receptor binding and activity. In fish, the 15-keto compounds serve as post-ovulatory pheromones and are more active than the parent prostaglandins.
T83193	Acetyl-Heme-Binding Protein 1 (1-21) (human)
	Acetyl-Heme-Binding Protein 1 (1-21) (human)为一种由Acetyl-Heme-Binding Protein 1前21个氨基酸组成的短肽。该肽具有与血红素结合的能力，参与血红素代谢及血红蛋白释放过程。
T83148	Alarin (human)
	Alarin (human) 属于下丘脑甘丙肽家族，包含 GALP 前体肽的信号序列和成熟 GALP 前 5 个氨基酸。
T71147	PBS-1086
	PBS-1086 is a novel dual inhibitor of the canonical and noncanonical NF-κB pathways, increasing the magnitude and duration of initial EGFR inhibitor response in multiple NSCLC models, decreasing PDHK1 expression, and suppressing phosphorylation of the PDHK1 protein substrate PDHA1 in a panel of PTEN-deficient cell lines.
T76064L	Beta-defensin 103 isoform X1, pig TFA
	Beta-defensin 103 isoform X1, pig TFA 是一种抗菌肽、在多种生物体内被发现，参与了先天性免疫防线。
T38895	Zanapezil free base TAK-147 free base,Zanapezil free base
	Zanapezil (TAK-147) is a powerful and selective inhibitor of acetylcholine esterase (AChE). It demonstrates significant and reversible inhibition of AChE activity in rat cerebral cortex homogenates (IC50 = 51.2 nM). Furthermore, Zanapezil exhibits moderate inhibition of muscarinic M1 and M2 receptor binding with Ki values of 234 and 340 nM, respectively. This compound holds promise for the investigation of the initial stages of Alzheimer's disease (AD).
T76266	Evybactin
	Evybactin 是DNA 旋转酶的抑制剂。Evybactin 是结核杆菌的选择性抑制剂，MIC 值为 0.25 µg/mL。Evybactin 是一个被发现的具有这种选择性机制的抗菌化合物。
T60667	NAT
	NAT 是 NAMPT 激活剂的苗头化合物。NAMPT 是研究与 NAD 耗竭相关的许多疾病，例如如神经退行性疾病的有吸引力的靶点，由于其为 NAD 回收途径中的限速酶。
T76151	Glycerol kinase
	Glycerol kinase (GyK) 甘油激酶是一种细菌糖激酶，常用于生化研究。Glycerol kinase 通过将三醇转化为甘油-3-p (G3P) 来催化甘油代谢。Glycerol kinase 对于调节细胞中不依赖通道/促进因子的甘油摄取至关重要。
T83872	Oleoyl-L-carnitine chloride L-Carnitine oleoyl ester,L-Octadecanoylcarnitine,C18:1 Carnitine,CAR 18:1
	Oleoyl-L-carnitine是一种长链酰基肉碱，也是一种糖苷转运体2（GlyT2；IC50 = 340 nM）的抑制剂，对GlyT2比对GlyT1（IC50 = >10,000 nM）具有选择性。慢性肾脏病或接受初始血液透析的终末期肾脏病患者的血浆中Oleoyl-L-carnitine水平增高，这与心血管死亡率相关。
T79928	Phosphomannose isomerase
	Phosphomannose isomerase 是 GDP-Man 生物合成途径中关键的首要酶，负责催化 Fru6P 与 Man6P 之间的互转。该酶对于细胞壁合成及蛋白质糖基化过程至关重要。同时，作为一种潜在的抗真菌靶点，Phosphomannose isomerase 可以有效抑制 A. flavus。
T76290	Exendin-4 (3-39)
	Exendin-4 (3-39) 是一种肽。Exendin-4 (3-39) 是 Exendin-4 的截断形式，缺少前两个氨基酸。Exendin-4 是一种有效的 GLP-1r 激动剂。Exendin-4 (3-39) 和 Exendin-4 可用于糖尿病和下丘脑-垂体-肾上腺 (HPA) 轴的研究。
T37256	12-oxo Leukotriene B4 12-oxo Leukotriene B4
	Leukotriene B4 (LTB4) is a dihydroxy fatty acid derived from arachidonic acid through the 5-LO pathway. It promotes a number of leukocyte functions including aggregation, stimulation of ion fluxes, enhancement of lysosomal enzyme release, superoxide anion production, chemotaxis, and chemokinesis. 12-oxo LTB4 is an initial metabolite of LTB4 formed via the LTB4 12-hydroxydehydrogenase pathway. It is rapidly converted to 10,11-dihydro-12-oxo-LTB4, followed by reduction of the 12-oxo group to give ...
T69862	Afeletecan HCl
	Afeletecan, also known as BAY 56-3722, is a water-soluble camptothecin derivative conjugated to a carbohydrate moiety exhibiting antineoplastic activity. BAY 56-3722 stabilizes the topoisomerase I-DNA covalent complex and forms an enzyme-drug-DNA ternary complex. As a consequence of the formation of this complex, both the initial cleavage reaction and religation steps are inhibited and subsequent collision of the replication fork with the cleaved strand of DNA results in inhibition of DNA repli...
T37396	13-epi-12-oxo Phytodienoic Acid
	13-epi-12-oxo Phytodienoic acid (13-epi-12-oxo PDA) is a lipoxygenase metabolite of α-linolenic acid in the leaves of green plants such as corn. ω-3 and ω-6 polyunsaturated fatty acids in plants are substrates for plant lipoxygenases. 12-oxo PDA is one of the best studied end metabolites of this enzymatic pathway. While the initial enzymatic product and major isomer of 12-oxo PDA contains side chains in the cis position, both being β to the ring, the upper side chain attached at C-13, can and fr...
T38292	4-(N-Boc-amino)piperidine
	4-(N-Boc-amino)piperidine is an organic building block.1,2It has been used in the synthesis of aminopiperidine antiviral chemokine (C-C motif) receptor 5 (CCR5) antagonists and antibacterial agents. 1.Burrows, J.N., Cumming, J.G., Fillery, S.M., et al.Modulators of the human CCR5 receptor. Part 1: Discovery and initial SAR of 1-(3,3-diphenylpropyl)-piperidinyl amides and ureasBioorg. Med. Chem. Lett.15(1)25-28(2005) 2.Reck, F., Alm, R., Brassil, P., et al.Novel N-linked aminopiperidine inhibitor...
T83663	Mn(III) Protoporphyrin IX Chloride Manganese(III) Protoporphyrin IX Chloride
	Mn(III) protoporphyrin IX chloride是一种金属卟啉，当浓度为10 µM时，能在鸡胚肝细胞中诱导δ-氨基酮戊二酸合成酶和血红素加氧酶(HO)基因的mRNA表达，这些酶分别催化血红素生物合成和降解的限速步骤。Mn(III) protoporphyrin IX chloride含纳米仿生物已被用于体外纤维蛋白凝块的磁共振成像(MRI)研究。此外，它还被用于Mn(III) protoporphyrin IX-6(7)-甘氨酰-甘氨酰-L-组氨酸甲酯(MnGGH)的合成，MnGGH是一种具有微过氧化物酶活性的金属卟啉衍生物。
T36982	CXCR3 Antagonist 6c
	CXCR3 antagonist 6c is an antagonist of chemokine (C-X-C motif) receptor 3 (CXCR3).1It inhibits calcium mobilization induced by chemokine (C-X-C motif) ligand 11 (CXCL11) in HEK293 cells expressing the human receptor (IC50= 0.06 μM). It is selective for CXCR3 over a panel of 14 human G protein-coupled receptors at 10 μM. CXCR3 antagonist 6c inhibits CXCR3-mediated migration of isolated human T cells (IC50= ~100 nM). 1.Cole, A.G., Stroke, I.L., Brescia, M.-R., et al.Identification and initial eva...

化合物

Nonaethylene glycol monododecyl ether

Cat.No: T16335

Synonym: Nonaoxyethylene monododecyl ether,Polidocanol,聚醚醇

Target: Others

Cat.No: T0765

Synonym: Antizol-Vet,4-甲基吡唑,甲吡唑,4-Methylpyrazole,Antizol

Target: P450, CAT, AChR

Cat.No: T2283

Synonym: 2-[(1-甲基丙基)二硫代]-1H-咪唑,IV-2,PX12

Target: Thioredoxin

Cat.No: T28823

Synonym: SNAP7941

Omadacycline mesylate

Cat.No: T5189L

Synonym: PTK 0796,PTK-0796,PTK0796

Ac-Arg-Gly-Lys(Ac)-AMC

Cat.No: T36686

Furosine dihydrochloride

Cat.No: T39054

Afeletecan free base

Cat.No: T23654

Synonym: BAY 56-3722,BAY56-3722,BAY-563722,Afeletecan

HOOCCH2O-PEG4-CH2COOH

Cat.No: T15499

Target: Others

Benzylacyclouridine

Cat.No: T40932

Synonym: 5-Benzylacyclouridine,BAU

Beta-defensin 103 isoform X1, pig

Cat.No: T76064

Cat.No: T73216

Cat.No: T70316

Y27632 HCl hydrate

Cat.No: T69429

Cat.No: T81413

15-keto Prostaglandin F1α

Cat.No: T37990

Synonym: 15-keto Prostaglandin F1α

Acetyl-Heme-Binding Protein 1 (1-21) (human)

Cat.No: T83193

Cat.No: T83148

Cat.No: T71147

Beta-defensin 103 isoform X1, pig TFA

Cat.No: T76064L

Zanapezil free base

Cat.No: T38895

Synonym: TAK-147 free base,Zanapezil free base

Cat.No: T76266

Cat.No: T60667

Glycerol kinase

Cat.No: T76151

Oleoyl-L-carnitine chloride

Cat.No: T83872

Synonym: L-Carnitine oleoyl ester,L-Octadecanoylcarnitine,C18:1 Carnitine,CAR 18:1

Phosphomannose isomerase

Cat.No: T79928

Exendin-4 (3-39)

Cat.No: T76290

12-oxo Leukotriene B4

Cat.No: T37256

Synonym: 12-oxo Leukotriene B4

Cat.No: T69862

13-epi-12-oxo Phytodienoic Acid

Cat.No: T37396

4-(N-Boc-amino)piperidine

Cat.No: T38292

Mn(III) Protoporphyrin IX Chloride

Cat.No: T83663

Synonym: Manganese(III) Protoporphyrin IX Chloride

CXCR3 Antagonist 6c

Cat.No: T36982

Cat. No.	Product Name	Target	Signaling Pathways
T19125	3-Phenylbutyric acid	Others; Endogenous Metabolite	Metabolism; Others
	3-Phenylbutyric acid 从堆肥土壤中分离出 Rhodococcus rhodochrous PB1，通过苯环的初始氧化和侧链的初始氧化进行代谢。
T4776	Glycerol Glycerin,甘油	Endogenous Metabolite	Metabolism
	Glycerol 是甘油三酯（即脂肪和油）和磷脂的重要成分。它在食品工业中被广泛用作甜味剂和保湿剂以及药物制剂。
T40924	Tellimagrandin II Eugeniin
	Tellimagrandin II (Eugeniin) is the initial intermediate in the 4 C 1 -glucose derived series of ellagitannins. Additionally, it possesses the ability to inhibit antibiotic resistance exhibited by drug-resistant Staphylococcus aureus.
T2S2363	Corydine	IL Receptor; Antifection	Immunology/Inflammation; Microbiology/Virology
	Corydine is the adrenolytic and weak cholinergic agent, it shows antimicrobial, and antineoplastic activities. Corydine shows irritant and respiratory stimulant and CNS depressant activities. Injected intravenously in rabbits corydine produced an initial
TN3351	Aflatrem	GABA Receptor	Membrane transporter/Ion channel; Neuroscience
	Aflatrem is a tremorgenic mycotoxin with acute neurotoxic effects, a single low dose of aflatrem is able to induce degeneration of neuronal processes in hippocampal neurotransmitter systems. Aflatrem potentiates the gamma-aminobutyric acid (GABA)-induced

天然产物

3-Phenylbutyric acid

Cat.No: T19125

Target: Others, Endogenous Metabolite

Cat.No: T4776

Synonym: Glycerin,甘油

Target: Endogenous Metabolite

Tellimagrandin II

Cat.No: T40924

Synonym: Eugeniin

Cat.No: T2S2363

Target: IL Receptor, Antifection

Cat.No: TN3351

Target: GABA Receptor

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