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Search Results for " estrogenic "

24

抑制剂 & 化合物

26

天然产物

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Cat. No.	Product Name	Target	Signaling Pathways
T23647	Zindoxifene D 16726	Estrogen/progestogen Receptor	Endocrinology/Hormones
	Zindoxifene (D 16726) 是一种抗雌激素化合物，具有抗肿瘤活性，可用于研究乳腺癌和前列腺癌。
T7465	4-Methylbenzylidene camphor Enzacamene,4-甲基苄亚基樟脑,3-(4-甲基苯亚甲基)樟脑,4-MBC	AChE	Neuroscience
	4-Methylbenzylidene camphor 是有机的樟脑衍生物，应用于化妆品行业，具有保护皮肤抵抗紫外线（特别是紫外线B 辐射）的能力。
T12654	(Rac)-Acolbifene (Rac)-EM-652,EM-343,阿考比芬	Estrogen Receptor/ERR	Endocrinology/Hormones
	(Rac)-Acolbifene (EM-343) 是 Acolbifene 的外消旋形式。Acolbifene 是一种 estrogen receptor 拮抗剂。(Rac)-Acolbifene 显示出抗雌激素和雌激素活性。 (Rac)-Acolbifene 包含哌啶环，显示出良好的药理作用，RBA=380。
T8981	WAY-169916 WAY 169916,WAY169916	NF-κB	NF-κB
	WAY-169916 是雌激素受体 (ER) 的通路选择性抑制剂。它通过抑制 NF-kB 转录活性而发挥作用，但没有常规的雌激素活性。
T9796	22393-62-0_peak 2
	22393-62-0_peak 2 exhibits some aspects of the antiestrogenic activity and other actions that may be connected to the estrogenic properties. A mixture of the (Z)- and (E)-isomers (Broparestrol, INN) is used in dermatology.
T33876L	Panomifene HCl EGIS5650 HCl,GYKI 13504 HCl,Panomifene HCl(77599-17-8 Free base),EGIS 5650 HCl	HER	Angiogenesis; JAK/STAT signaling; Tyrosine Kinase/Adaptors
	Panomifene HCl 是一种选择性抗雌激素化合物，具有抗肿瘤活性，可用于治疗乳腺癌。
T13684	Equilin 7-Dehydroestrone	Calcium Channel	Membrane transporter/Ion channel; Metabolism
	Equilin (7-Dehydroestrone) 是神经营养性雌激素类固醇，具有血管扩张活性，通过 NF-κB 信号传导增加单核细胞-内皮粘附。Equilin 通过阻断Ca（2+）进入平滑肌来同样放松肠系膜动脉的阻力。
T1514	Norethindrone Norethisterone,炔诺酮	Estrogen/progestogen Receptor; Progesterone Receptor	Endocrinology/Hormones; Others
	Norethindrone (Norethisterone) 是孕激素，能够用于子宫内膜异位症、由激素水平异常引起的子宫出血和继发性闭经的研究。
T8984	FLTX1	Estrogen Receptor/ERR; Estrogen/progestogen Receptor	Endocrinology/Hormones
	FLTX1 is a fluorescent derivative of Tamoxifen, designed to efficiently target and label intracellular Tamoxifen-binding sites (estrogen receptors) both under permeabilized and non-permeabilized conditions. Additionally, FLTX1 demonstrates strong antiestrogenic activity in breast cancer cells, resembling the potent antiestrogenic properties of Tamoxifen. Notably, FLTX1 does not exhibit any estrogenic agonistic effect on the uterus.
T2569	Chlorotrianisene tris(p-methoxyphenyl)chloroethylene,氯丁烯二烯,CTA,tri-p-anisylchloroethylene,氯烯雌醚,TACE	Estrogen Receptor/ERR; Estrogen/progestogen Receptor; COX	Endocrinology/Hormones; Immunology/Inflammation; Neuroscience
	Chlorotrianisene (tri-p-anisylchloroethylene) 是长效、可口服、亲脂性高的合成三苯乙烯 (TPE) 衍生物和选择性雌激素受体调节剂，有雌激素活性，也有抗雌激素活性。它还有效抑制COX-1并抑制全血中的血小板聚集。
T20938	o,p'-DDT 2,4'-DDT,ortho,para'-DDT
	O,P'-DDT, a chlorinated organic pesticide, has estrogenic activity.
T38272	Thiacloprid	AChR; Parasite	Microbiology/Virology; Neuroscience
	Thiacloprid 属于氯烟碱类杀虫剂，主要用于防治蔬菜和果园中的蚜虫。它会破坏 DNA 的稳定性，通过疏水或氢相互作用，结合到小沟槽中，改变 DNA 的结构和稳定性。
T23737	Anordiol H 241,H241,AF-45,AF 45,AF45
	Anordiol is an antiestrogen with estrogenic activity. It also is known to inhibit fertility.
T20764	Dienestrol diacetate NSC 81279,NSC81279,Cycladiene,Retalon-oral,Oestrasid C,NSC-81279
	Dienestrol diacetate, a derivative of the synthetic non-steroid phenolic compound, DIENESTROL, exhibits estrogenic activities.
T70980	PBRM
	PBRM is the first selective, potent, non-estrogenic, irreversible inhibitor of 17β-HSD1.
T38379	4-tert-Octylphenol diethoxylate
	4-tert-Octylphenol diethoxylate is a degradation product of the multi-purpose surfactant, Triton X. A known environmental contaminant, 4-tert-octylphenol diethoxylate is reported to be an endocrine disruptor in animal and human research studies, producing weak estrogenic effects.
T69696	TAS-108 citrate
	TAS-108, also known as SR16234, is a synthetic, antiestrogenic steroidal compound with potential antitumor activity. TAS-108 binds to and inhibits estrogenic receptor alpha (ERa), mainly expressed in the mammary gland and uterus and upregulated in estrogen-dependent tumors. Blockage of ERa by TAS-108 prevents the binding and effects of estrogen and may lead to an inhibition of estrogen-dependent cancer cell proliferation. TAS-108 also is a partial agonist of the estrogenic receptor beta (ERb), e...
T39259	Arzoxifene LY353381,Arzoxifene,SERMIII
	Arzoxifene (LY353381) is an orally active selective estrogen receptor modulator (SERM) exhibiting a fixed ring structure analogous to raloxifene. This compound demonstrates potent antiestrogenic effects on breast cancer and endometrium while displaying minimal side effects. Additionally, Arzoxifene elicits favorable estrogenic effects on bone health and lipid profile.
T10273	AhR modulator-1	Others	Others
	AhR modulator-1 is a selective and orally active aryl hydrocarbon receptor (AhR) modulator. It inhibits metastasis, in part, by inhibiting prostatic VEGF production prior to tumor formation. It also possesses anti-estrogenic properties in rat uterus.
T37647	5α-dihydro Levonorgestrel
	5α-dihydro Levonorgestrel is a metabolite of the synthetic progestin levonorgestrel . It lacks in vitro and in vivo estrogenic activity, but induces copulatory behavior in male rats when administered at a dose of 1 mg per animal per day.
T82366	Fulvestrant 3-β-D-Glucuronide
	Fulvestrant 3-β-D-Glucuronide，Fulvestrant的代谢产物，为葡萄糖醛酸结合物，属于纯抗雌激素类固醇。该化合物可应用于乳腺癌研究领域。
T62572	Enclomiphene hydrochloride
	Enclomiphene ((E)-Clomiphene) hydrochloride 是一种口服具有活力的、有效的非甾体雌激素受体 (estrogen receptor) 拮抗剂，具有抗雌激素作用。Enclomiphene hydrochloride 能够用于研究卵巢功能障碍、睾酮缺乏、男性性腺功能减退症和 type 2 型糖尿病。
T35783	Zearalenone-13C18 Zearalenone-13C18
	Zearalenone-13C18is intended for use as an internal standard for the quantification of zearalenone by GC- or LC-MS. Zearalenone is a mycotoxin that has been found inFusariumand has estrogenic activities.1It binds to human estrogen receptor α (ERα) and ERβ (IC50s = 9 and 5.8 nM, respectively).2Zearalenone induces precocious development of mammary tissues in young female pigs and prepucial enlargement in young male pigs.3Zearalenone (1.5-5 mg/kg of diet) induces hyperestrogenism in pigs. It also i...
T36913	17-Epiestriol
	17-Epiestriol is a metabolite of estrone .1It is formed from estroneviaa 16α-hydroxy estrone intermediate by reduction of the C-17 ketone. 17-Epiestriol binds to estrogen receptor α (ERα) and ERβ with relative binding affinities of 29 and 80 compared with 17β-estradiol .2 1.Brinton, L.A., Trabert, B., Anderson, G.L., et al.Serum estrogens and estrogen metabolites and endometrial cancer risk among postmenopausal womenCancer Epidemiol. Biomarkers Prev.25(7)1081-1089(2016) 2.Kuiper, G.G.J.M., Lemme...

化合物

Cat.No: T23647

Synonym: D 16726

Target: Estrogen/progestogen Receptor

4-Methylbenzylidene camphor

Cat.No: T7465

Synonym: Enzacamene,4-甲基苄亚基樟脑,3-(4-甲基苯亚甲基)樟脑,4-MBC

Target: AChE

(Rac)-Acolbifene

Cat.No: T12654

Synonym: (Rac)-EM-652,EM-343,阿考比芬

Target: Estrogen Receptor/ERR

Cat.No: T8981

Synonym: WAY 169916,WAY169916

Target: NF-κB

22393-62-0_peak 2

Cat.No: T9796

Cat.No: T33876L

Synonym: EGIS5650 HCl,GYKI 13504 HCl,Panomifene HCl(77599-17-8 Free base),EGIS 5650 HCl

Target: HER

Cat.No: T13684

Synonym: 7-Dehydroestrone

Target: Calcium Channel

Cat.No: T1514

Synonym: Norethisterone,炔诺酮

Target: Estrogen/progestogen Receptor, Progesterone Receptor

Cat.No: T8984

Target: Estrogen Receptor/ERR, Estrogen/progestogen Receptor

Chlorotrianisene

Cat.No: T2569

Synonym: tris(p-methoxyphenyl)chloroethylene,氯丁烯二烯,CTA,tri-p-anisylchloroethylene,氯烯雌醚,TACE

Target: Estrogen Receptor/ERR, Estrogen/progestogen Receptor, COX

Cat.No: T20938

Synonym: 2,4'-DDT,ortho,para'-DDT

Cat.No: T38272

Target: AChR, Parasite

Cat.No: T23737

Synonym: H 241,H241,AF-45,AF 45,AF45

Dienestrol diacetate

Cat.No: T20764

Synonym: NSC 81279,NSC81279,Cycladiene,Retalon-oral,Oestrasid C,NSC-81279

Cat.No: T70980

4-tert-Octylphenol diethoxylate

Cat.No: T38379

TAS-108 citrate

Cat.No: T69696

Cat.No: T39259

Synonym: LY353381,Arzoxifene,SERMIII

AhR modulator-1

Cat.No: T10273

Target: Others

5α-dihydro Levonorgestrel

Cat.No: T37647

Fulvestrant 3-β-D-Glucuronide

Cat.No: T82366

Enclomiphene hydrochloride

Cat.No: T62572

Zearalenone-13C18

Cat.No: T35783

Synonym: Zearalenone-13C18

Cat.No: T36913

Cat. No.	Product Name	Target	Signaling Pathways
T1009	Estrone Oestrone,雌酮,Fluoroethyl,Aquacrine	Estrogen Receptor/ERR; Estrogen/progestogen Receptor; Endogenous Metabolite	Endocrinology/Hormones; Metabolism
	Estrone (Aquacrine) 是内源性雌激素的主要代表，由多种组织产生，尤其是脂肪组织。它是脂肪细胞中雄烯二酮芳构化过程的结果。
T12581	Puerarin-4'-O-β-D-glucopyranoside Puerarin4'-O-glucoside,葛根素-4'-Β-D-葡萄糖苷	Others	Others
	Puerarin-4'-O-β-D-glucopyranoside (Puerarin4'-O-glucoside) 是一种从葛根 (PLR) 中提取的异黄酮。它具有雌激素活性和抗 MCF-7 人乳腺癌细胞增殖作用。
T9454	4-Hydroxyestrone	Estrogen Receptor/ERR; Endogenous Metabolite	Endocrinology/Hormones; Metabolism
	4-Hydroxyestrone 是一种内源性雌激素代谢物，可强烈保护神经元细胞免受氧化损伤。
T1424	Ethynyl estradiol 乙炔基雌二醇,17α-Ethynylestradiol,Ethinyl Estradiol,炔雌醇	Estrogen Receptor/ERR; Estrogen/progestogen Receptor; Endogenous Metabolite	Endocrinology/Hormones; Metabolism
	Ethynyl estradio 是一种高效的生物活性雌激素。
T7957	2-Isopropyl Thioxanthone	Others	Others
	2-Isopropyl Thioxanthone 具有潜在的抗雌激素和抗雄激素特性。
T0345	Estropipate 雌酮硫酸酯哌嗪,Piperazine estrone sulfate,Pipestrone,Estrone sulfate piperazine salt	Estrogen Receptor/ERR; Estrogen/progestogen Receptor	Endocrinology/Hormones
	Estropipate (Piperazine estrone sulfate) 是一种由硫酸雌酮和哌嗪组成的天然雌激素物质。
T6S0325	Glycitein 黄豆黄素,Glycetein	Apoptosis; Others	Apoptosis; Others
	Glycitein (Glycetein) 是一种大豆异黄酮，可研究抗氧化和细胞凋亡。
TN1146	8-Prenylnaringenin 8-Prenylnaringenin,8-异戊烯基柚皮素	Apoptosis; ROS	Apoptosis; Immunology/Inflammation
	8-prenylnaringenin 是一种从啤酒花穗中分离到的异戊烯类黄酮，具有细胞毒性。它能通过激活小鼠 Akt 磷酸化途径，使其从静止诱导的停用性肌肉萎缩中恢复。它能通过诱导内源性和外源性通路介导的凋亡，对 HCT-116 结肠癌细胞产生抗增殖活性。
T3665	Tectoridin 射干苷,Shekanin	Estrogen Receptor/ERR; Reductase	Endocrinology/Hormones; Metabolism
	Tectoridin (Shekanin) 是分离自 Maackia amurensis 中的异黄酮，是一种植物雌激素，能够激活雌激素和甲状腺激素受体。它通过 ER 依赖性基因组途径和 GPR30 依赖性非基因组途径发挥雌激素作用。
T5S0993	Kurarinone 苦参酮,苦参黄素	BCL; Others; IκB/IKK; TNF; NF-κB; JAK; STAT	Angiogenesis; Apoptosis; Chromatin/Epigenetic; JAK/STAT signaling; NF-κB; Others; Stem Cells
	Kurarinone 是从灌木苦参中提取的黄酮类化合物，具有抗肿瘤、雌激素和抗炎活性，对免疫反应也有很强的抑制作用。
T5625	Zearalenone 玉米,Mycotoxin F2,玉米烯酮,RAL,F2 toxin,Toxin F2	Others	Others
	Zearalenone (F2 toxin) 是真菌毒素，主要由食物和饲料中的 Fusarium 产生。它会引起幼龄母猪乳房发育早熟或其它雌激素效应。它在猪、牛、羊体内具有雌激素活性，急性毒性低。
T64353	4-tert-Octylphenol	Endogenous Metabolite	Metabolism
	4-tert-Octylphenol 是一种干扰内分泌的化学物质及雌激素药物，能诱导子代小鼠脑神经元祖细胞的凋亡，并通过减少溴脱氧尿苷（BrdU）、有丝分裂标志物Ki67以及磷酸组蛋白H3（p-Histone-H3）的表达，导致神经元祖细胞的增殖减少。这种物质不仅会干扰小鼠的大脑发育，还会影响其行为。
T36914	2-Hydroxyanthraquinone	Others	Others
	2-Hydroxyanthraquinone 是一种天然产物，显示出抗肿瘤和免疫抑制活性。
T13577	β-Zearalenol	Others	Others
	β-Zearalenol, a non-steroidal estrogenic mycotoxin synthesized by Fusarium species, potentially influences transcription and affects gene expression on the translational level.
TN4875	Quercetin 3,3'-dimethyl ether	Others	Others
	Quercetin 3,3'-dimethyl ether may have moderate estrogenic activity.
TN1679	Genistein 7,4'-di-O-β-D-glucoside 染料木素-7,4'-二-O-Β-D-葡萄糖苷,Genistein 7,4'-di-O-beta-D-glucopyranoside,鲁冰花	Others; Estrogen/progestogen Receptor	Endocrinology/Hormones; Others
	Genistein 7,4'-di-O-beta-D-glucopyranoside shows significant estrogenic proliferative effect in MCF-7 cell in sub-cytotoxic concentration range.
T13391	Zearalanone	Others	Others
	Zearalenone is a nonsteroidal estrogenic mycotoxin produced by Fusarium species, which colonizes several grains.
TN1573	Desmethylxanthohumol	Others	Others
	Desmethylxanthohumol shows estrogenic activity.
TN2045	Pelargonidin-3-O-glucoside chloride	Others; Estrogen/progestogen Receptor	Endocrinology/Hormones; Others
	Pelargonidin-3-O-glucopyranoside is the glucoside of Pelargonidin, an potential antidiabetic agent. Pelargonidin-3-O-glucopyranoside has antioxidant, anti-inflammatory, anti-estrogenic, and angiotensin-converting enzyme inhibitory activities.
TN2224	Soyasapogenol A 大豆甾醇A,大豆甾醇 A	TNF	Apoptosis
	Soyasapogenol A shows estrogenic and hepatoprotective activities, it directly prevents apoptosis of hepatocytes, and secondly, inhibits the elevation of plasma TNF-α±, which consequently resulted in the prevention of liver damage in the concanavalin A-induced hepatitis model.
TN4383	Kazinol U	IL Receptor; IκB/IKK; NOS; NF-κB	Immunology/Inflammation; NF-κB
	Kazinol U may have therapeutic value in delaying pancreatic β-cell destruction in type 1 diabetes by blocking the NF-ÎºB pathway in pancreatic β-cells reduces cell damage. Kazinol U shows estrogenic activity with ligand-activity of estrogen receptor, transcriptional activity of estrogen -responsive element-reporter genes, it may have beneficial effects in the treatment of menopausal symptoms.
TN3397	Alpinumisoflavone	ERK; LDL; NF-κB; MEK; MAPK; Antifection	MAPK; Metabolism; Microbiology/Virology; NF-κB
	Alpinumisoflavone has atheroprotective effects, may result from their ability to upregulate mechanisms promoting HDL-cholesterol and bile acid formation, it is endowed with estrogenic properties accounting, at least in part, for E. lysistemon effects. Alp
TN5456	Isoerysenegalensein E
	Isoerysenegalensein E shows anti-estrogenic activity comparable to that of 4-hydroxytamoxifen, a typical estrogen receptor antagonist. It shows significant cytotoxicity against HL-60 cells, it induces apoptosis in HL-60 cells through activation of the cas
T83301	5,7-Dimethoxy-2,3-phenanthrenediol
	5,7-Dimethoxy-2,3-phenanthrenediol 表现出雌激素活性，能够促进MCF-7细胞的增殖，并增强ERβ在MCF-7细胞系中的表达。
TN3380	Alloisoimperatorin	AChR	Neuroscience
	Alloisoimperatorin is a candidate of AChE inhibitors, it displays potent antioxidant effects against the DPPH radical and against renal epithelial cell injury by using AAPH to generate peroxyl radicals in vitro. Alloisoimperatorin has estrogenic activity
TN3539	Broussonin A	ERK; IL Receptor; IκB/IKK; NOS; NF-κB; Akt	Cytoskeletal Signaling; Immunology/Inflammation; MAPK; NF-κB; PI3K/Akt/mTOR signaling
	Broussonins A and B, new phytoalexins from diseased paper mulberry. Broussonin A shows estrogenic activity with ligand-binding activity of estrogen receptor, transcriptional activity of estrogen-responsive element-luciferase reporter genes. Broussonin A c

天然产物

Cat.No: T1009

Synonym: Oestrone,雌酮,Fluoroethyl,Aquacrine

Target: Estrogen Receptor/ERR, Estrogen/progestogen Receptor, Endogenous Metabolite

Puerarin-4'-O-β-D-glucopyranoside

Cat.No: T12581

Synonym: Puerarin4'-O-glucoside,葛根素-4'-Β-D-葡萄糖苷

Target: Others

4-Hydroxyestrone

Cat.No: T9454

Target: Estrogen Receptor/ERR, Endogenous Metabolite

Ethynyl estradiol

Cat.No: T1424

Synonym: 乙炔基雌二醇,17α-Ethynylestradiol,Ethinyl Estradiol,炔雌醇

Target: Estrogen Receptor/ERR, Estrogen/progestogen Receptor, Endogenous Metabolite

2-Isopropyl Thioxanthone

Cat.No: T7957

Target: Others

Cat.No: T0345

Synonym: 雌酮硫酸酯哌嗪,Piperazine estrone sulfate,Pipestrone,Estrone sulfate piperazine salt

Target: Estrogen Receptor/ERR, Estrogen/progestogen Receptor

Cat.No: T6S0325

Synonym: 黄豆黄素,Glycetein

Target: Apoptosis, Others

8-Prenylnaringenin

Cat.No: TN1146

Synonym: 8-Prenylnaringenin,8-异戊烯基柚皮素

Target: Apoptosis, ROS

Cat.No: T3665

Synonym: 射干苷,Shekanin

Target: Estrogen Receptor/ERR, Reductase

Cat.No: T5S0993

Synonym: 苦参酮,苦参黄素

Target: BCL, Others, IκB/IKK, TNF, NF-κB, JAK, STAT

Cat.No: T5625

Synonym: 玉米,Mycotoxin F2,玉米烯酮,RAL,F2 toxin,Toxin F2

Target: Others

4-tert-Octylphenol

Cat.No: T64353

Target: Endogenous Metabolite

2-Hydroxyanthraquinone

Cat.No: T36914

Target: Others

Cat.No: T13577

Target: Others

Quercetin 3,3'-dimethyl ether

Cat.No: TN4875

Target: Others

Genistein 7,4'-di-O-β-D-glucoside

Cat.No: TN1679

Synonym: 染料木素-7,4'-二-O-Β-D-葡萄糖苷,Genistein 7,4'-di-O-beta-D-glucopyranoside,鲁冰花

Target: Others, Estrogen/progestogen Receptor

Cat.No: T13391

Target: Others

Desmethylxanthohumol

Cat.No: TN1573

Target: Others

Pelargonidin-3-O-glucoside chloride

Cat.No: TN2045

Target: Others, Estrogen/progestogen Receptor

Soyasapogenol A

Cat.No: TN2224

Synonym: 大豆甾醇A,大豆甾醇 A

Target: TNF

Cat.No: TN4383

Target: IL Receptor, IκB/IKK, NOS, NF-κB

Alpinumisoflavone

Cat.No: TN3397

Target: ERK, LDL, NF-κB, MEK, MAPK, Antifection

Isoerysenegalensein E

Cat.No: TN5456

5,7-Dimethoxy-2,3-phenanthrenediol

Cat.No: T83301

Alloisoimperatorin

Cat.No: TN3380

Target: AChR

Cat.No: TN3539

Target: ERK, IL Receptor, IκB/IKK, NOS, NF-κB, Akt

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