Xamoterol hemifumarate

Name: Xamoterol hemifumarate
Brand: TargetMol
SKU: T23536
Price: 596 CNY
Availability: InStock
Rating: 5 (10 reviews)

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很棒

纯度: 99.79%

货号 T23536Cas号 73210-73-8

别名 富马酸扎莫特罗, ICI 118587 hemifumarate, Corwin hemifumarate

Xamoterol hemifumarate 是一种具有强效性和选择性的β1-肾上腺素受体激动剂。Xamoterol hemifumarate 是研究心律失常和 β1-肾上腺素能刺激与 IKr 之间关系的潜在化合物。

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Xamoterol hemifumarate

一键复制产品信息

很棒

纯度: 99.79%

货号 T23536 别名 富马酸扎莫特罗, ICI 118587 hemifumarate, Corwin hemifumarateCas号 73210-73-8

规格	价格	库存
1 mg	¥ 596	现货
5 mg	¥ 1,190	现货
10 mg	¥ 1,930	现货
25 mg	¥ 3,980	现货
50 mg	¥ 5,670	现货
100 mg	¥ 7,680	现货
200 mg	¥ 9,870	现货
1 mL x 10 mM (in DMSO)	¥ 987	现货

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纯度: 99.79%

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COA HNMR HPLC 产品操作手册

产品介绍

Xamoterol hemifumarate AI Summary

Xamoterol hemifumarate is a versatile bioactive agent exhibiting a broad spectrum of inhibitory and modulatory effects across various biological systems. It is a potent inhibitor of the Menin-MLL interaction relevant in MLL-related leukemias (35481.3 nM), a modulator of Lamin A splicing (8912.5 nM), and an inhibitor of Tau fibril formation (281.8 nM). Additionally, it inhibits Bloom's syndrome helicase (BLM) with a potency of 562.3 nM and demonstrates inhibition against histone lysine methyltransferase G9a (70794.6 nM). Notably, it inhibits Marburg virus binding or entry into cells at a potency of 56.2 nM. In SARS-CoV-2 assays, Xamoterol hemifumarate has an inhibition index of 0.4021 for cell viability in Vero E6 cells. Its effect on cell viability varies among cell types: positive in HEK293T cells (growth rates: 0.64 to 0.95), mixed in U2OS cells (growth rates: 0.31 to -1.0), and negative in human fibroblasts (growth rates: -0.01 to -0.24). The compound also influences protein stability differently across various domains, as shown by thermal shift assays, with Delta TM values ranging from stabilizing (0.09 C to 0.26 C) to destabilizing (-0.01 C to -2.12 C) effects. Furthermore, Xamoterol hemifumarate modulates GPCR signaling pathways, featuring multiple inhibitory actions across several GPCR targets (e.g., GLP1R, AGTR1, CX3CR1, ADRB2) with inhibition ranging from -5.96% to -85.67%, and a stimulating effect on ADGRF1 (%Max 29.7%). These diverse activities suggest its potential in modulating various signaling pathways and therapeutic targets..

Note: Summary generated by AI. Data source: ChEMBL

生物活性

产品描述	Xamoterol hemifumarate is a potent and selective β1-adrenoceptor agonist.Xamoterol hemifumarate is a potential compound for the study of the relationship between cardiac arrhythmias and β1-adrenergic stimulation with IKr.
别名	富马酸扎莫特罗, ICI 118587 hemifumarate, Corwin hemifumarate

化学信息

分子量	794.37
分子式	C₃₆H₅₄N₆O₁₄
CAS No.	73210-73-8
Smiles	OC(/C=C/C(O)=O)=O.OC(C=C1)=CC=C1OCC(O)CNCCNC(N2CCOCC2)=O.OC(C=C3)=CC=C3OCC(O)CNCCNC(N4CCOCC4)=O
密度	no data available
颜色	White
物理性状	Solid

储存&溶解度

存储

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

溶解度信息

DMSO: 80 mg/mL (100.71 mM), Sonication is recommended.

溶液配制表

DMSO

	1mg	5mg	10mg	50mg
1 mM	1.2589 mL	6.2943 mL	12.5886 mL	62.9430 mL
5 mM	0.2518 mL	1.2589 mL	2.5177 mL	12.5886 mL
10 mM	0.1259 mL	0.6294 mL	1.2589 mL	6.2943 mL
20 mM	0.0629 mL	0.3147 mL	0.6294 mL	3.1471 mL
50 mM	0.0252 mL	0.1259 mL	0.2518 mL	1.2589 mL
100 mM	0.0126 mL	0.0629 mL	0.1259 mL	0.6294 mL