enterococci

Vulpinic Acid (Pulvinic acid methyl ester) 是地衣代谢物，可降低人脐静脉内皮细胞 (HUVEC) 中 H2O2诱导的ROS，氧化应激和氧化应激相关损伤，可作用于厌氧菌、葡萄球菌及肠球菌。它对脉粥样硬化的研究具有潜在的价值。

Antibacterial compound 2 是一种有效的抗菌剂，对许多人类兽医病原体有效，对多重耐药葡萄球菌、肠球菌和链球菌，以及厌氧菌有抑制作用。

Vancomycin hydrochloride (Vancomycin HCl) 是一种糖肽类抗生素,靶点是细菌细胞壁合成中的肽聚糖 (Peptidoglycan)。Vancomycin hydrochloride主要用于治疗严重的革兰阳性菌感染。

AVX 13616 shows the potent in vivo antibacterial activity of Avexa’s lead antibacterial candidate; particularly against drug-resistant Staphylococcus pathogens. IC50 value: 2-4 ug/ml (MICs) Target: antibacterial agent AVX13616 was as active as mupirocin i

MRSA/VRE-IN-1 (Compound 3e) 是一种抑制剂，专门针对耐甲氧西林金黄色葡萄球菌 (MRSA) 和耐万古霉素肠球菌 (VRE)。该化合物对VRE的MIC/MBC值分别为3.6/7.3 µM，对MRSA的MIC/MBC值为7.3/14.6 µM。MRSA/VRE-IN-1 可用于抗感染领域的研究。

Antiviralagent 49 (compound 4q) 是一种双重抗病毒和抗菌剂，表现出抗肠球菌和抗葡萄球菌的活性。

Adicillin is a penicillin antibiotic that works against vancomycin-resistant enterococci.

Oritavancin is a novel semisynthetic glycopeptide antibiotics. On August 6, 2014, the FDA approved oritavancin for treatment of skin infections. Oritavancin possesses potent and rapid bactericidal activity in vitro against a broad spectrum of both resistant and susceptible Gram-positive bacteria, including Staphylococcus aureus, MRSA, enterococci, and streptococci.

Kocurin is a thiazolyl peptide originally isolated fromK. palustrisand has antibiotic activity.1It is active against methicillin-resistantS. aureus(MRSA; MIC = 0.25 μg/ml), as well asB. subtilisandE. faeciumin a solid agar test when used at a concentration of 8 μg/ml. Kocurin is also active againstE. faecium,E. faecalis,S. epidermidis, and clinical isolates of vancomycin-resistant enterococci (MICs = 0.004-1.025 μg/ml).2In vivo, kocurin (2.5, 5, and 10 mg/ml) increases survival in a mouse model ofE. faecium-induced septicemia. It decreases the number of colony forming units (CFUs) in a mouse model of MRSA lung infection. 1.Martin, J., da S. Sousa, T., Crespo, G., et al.Kocurin, the true structure of PM181104, an anti-methicillin-resistant Staphylococcus aureus (MRSA) thiazolyl peptide from the marine-derived bacterium Kocuria palustrisMar. Drugs11(2)387-398(2013) 2.Mahajan, G., Thomas, B., Parab, R., et al.In vitro and in vivo activities of antibiotic PM181104Antimicrob. Agents Chemother.57(11)5315-5319(2013)

Platencin is a natural, broad spectrum Gram-positive antibiotic isolated from S. platensis, which is also the source of platensimycin . Platencin inhibits two key enzymes in bacterial fatty acid synthesis, β-ketoacyl-ACP synthases II and III (FabF and FabH, respectively), unlike platensimycin which only targets FabF. The IC50 values for platencin against FabF and FabH are 1.95 and 3.91 μg/ml, respectively. It does not exhibit cross-resistance to antibiotic resistant bacterial strains, including methicillin-resistant S. aureus, vancomycin-intermediate S. aureus, and vancomycin-resistant Enterococci. For these reasons, platencin has potential applications in fighting antibiotic resistant bacteria.

Cefaloglycin（Cephaloglycin）是一种β-内酰胺类（β-lactam）口服活性头孢菌素类抗生素，具有肾毒性和抗菌活性。该药物对革兰氏阳性球菌（除肠球菌外）有效，同时对线粒体底物摄取及呼吸具有毒性。

Nemonoxacin (TG-873870) 是一种可口服的非氟化喹诺酮类抗生素，具有广谱的抗菌活性，抑制葡萄球菌、链球菌和肠球菌、淋病奈瑟菌和流感嗜血杆菌均。Nemonoxacin 可用于研究细菌感染和社区获得性肺炎。

6-(12-Tridecene-1-yl)-2,4-Dihydroxy benzoic acid (Compound 2) 在抗菌领域展现出显著效果，特别是对耐甲氧西林Staphylococcus aureus (MRSA)和Vancomycin enterococci (VRE)。该化合物能有效干扰细菌细胞膜的结构和功能，进而影响MRSA的代谢过程。除此之外，6-(12-Tridecene-1-yl)-2,4-Dihydroxy benzoic acid 还具备抗炎及促进小鼠血管生成的特性，显示其在抗感染治疗中的潜力。

Epicorazine B 在革兰氏阳性菌中表现出活性，包括耐甲氧西林金黄色葡萄球菌（MRSA）和耐万古霉素肠球菌（VRE），其最低抑菌浓度（MIC）为 12.5-25 μg/mL。Epicorazine B 还对白色念珠菌有效，MIC 为 25 μg/mL。

Chloropolysporin C 具有强效的抗革兰氏阳性菌活性，涵盖耐甲氧西林金黄色葡萄球菌（MRSA）和肠球菌。

Diperamycin 对革兰氏阳性菌（包括肠球菌和 MRSA）表现出活性，MIC 为 0.10-0.20 μg/mL。同时，它对 L1210、P388、LS-180、KB、HeLaS3、Meth A 和 B16-BL6 的活性有显著抑制作用，IC50 为 0.009-0.098 μg/mL。

Citreamicin alpha（LL-E 19085-alpha）是一种抗生素，通过琼脂稀释法已测试其对429株临床分离的革兰氏阳性球菌的体外抗菌活性，包括313株葡萄球菌和116株链球菌。该抗生素的体外活性与氨苄西林、阿莫西林、头孢噻吩、红霉素和万古霉素进行了比较。对葡萄球菌而言，Citreamicin alpha的MIC值在0.12-4.0 μg/ml范围内，而对Streptococcus pyogenes的MIC为0.03-0.12 μg/ml。肠球菌较为耐药，64%的测试株需要2.0 μg/ml的药物才能抑制。其抗菌活性显著优于氨苄西林、阿莫西林、头孢噻吩和红霉素，与万古霉素相当或略逊。

8-Epidiosbulbin E acetate 是从 Dioscorea bulbifera L. 中发现的丰富呋喃类化合物，具有对多重耐药菌广谱的质粒消除活性，可用于诱导小鼠肝损伤模型。

Glyasperin C acts as a partial estrogen antagonist, it shows tyrosinase inhibitory activity (IC (50) = 0.13 +/- 0.01 microg/mL), it could be a promising candidate in the design of skin-whitening agents. Glyasperin C shows potent anti-vancomycin-resistant

Chloropolysporin B 具备显著的抗革兰氏阳性菌特性，靶向包括耐甲氧西林金黄色葡萄球菌（MRSA）及肠球菌等。

Epicorazine A 对革兰氏阳性菌表现出活性，包括耐甲氧西林金黄色葡萄球菌 (MRSA) 和耐万古霉素肠球菌 (VRE)，其最低抑菌浓度 (MIC) 为 12.5-25 μg/mL。此外，Epicorazine A 对白色念珠菌的作用，MIC 为 25 μg/mL。