Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Tolamolol 是一种选择性 β肾上腺素能阻滞剂,能显著降低运动诱导的S-T段抑制程度,可用于治疗心律失常。
规格 | 价格/CNY | 货期 | 数量 | |
---|---|---|---|---|
1 mg | ¥ 735 | 现货 | ||
5 mg | ¥ 1,400 | 现货 | ||
10 mg | ¥ 1,960 | 现货 | ||
25 mg | ¥ 3,530 | 现货 | ||
50 mg | ¥ 4,620 | 现货 | ||
100 mg | ¥ 6,860 | 现货 | ||
500 mg | ¥ 13,700 | 现货 |
产品描述 | Tolamolol is a selective β-adrenergic blocker that significantly reduces the degree of exercise-induced inhibition of the S-T segment and can be used in the treatment of cardiac arrhythmias. |
体内活性 | Forty-two patients with angina pectoris have completed a randomized, double-blind trial comparing Tolamolol 100 mg and 200 mg with propranolol 80 mg, practolol 100 mg, and placebo, all given three times a day. Tolamolol 200 mg thrice daily was found to be equivalent to propranolol 80 mg thrice daily in anti-anginal efficacy. Anginal attack rates and trinitrin consumption were significantly reduced by all active treatments as compared with the placebo but Tolamolol and propranolol were the most effective. Tolamolol 200 mg thrice daily was most effective in reducing blood pressure, while propranolol was most effective in reducing the resting heart rate. All treatments except the placebo significantly increased the amount of exercise that could be performed before angina appeared (exercise work), while the Tolamolol 200 mg thrice daily significantly reduced Robinson's index when compared with all other active agents.[1] |
分子量 | 344.4 |
分子式 | C19H24N2O4 |
CAS No. | 38103-61-6 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
对于不同动物的给药剂量换算,您也可以参考 更多...
请在以下方框中输入您的动物实验信息后点击计算,可以得到母液配置方法和体内配方的制备方法: 比如您的给药剂量是10 mg/kg,每只动物体重20 g,给药体积100 μL,一共给药动物10 只,您使用的配方为5% DMSO+30% PEG300+5% Tween 80+60% ddH2O。那么您的工作液浓度为2 mg/mL。
母液配置方法:2 mg 药物溶于 50 μL DMSO (母液浓度为 40 mg/mL), 如您需要配置的浓度超过该产品的溶解度,请先与我们联系。
体内配方的制备方法:取 50 μL DMSO 主液,加入 300 μL PEG300, 混匀澄清,再加 50 μL Tween 80,混匀澄清,再加 600 μL ddH2O, 混匀澄清。
您可能有的问题的答案可以在抑制剂处理说明中找到,包括如何准备库存溶液,如何存储产品,以及基于细胞的分析和动物实验需要特别注意的问题。
Tolamolol 38103-61-6 GPCR/G Protein Neuroscience Adrenergic Receptor Inhibitor inhibitor inhibit