Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Samelisant (SUVN-G3031) 是 H3 受体的特异性反向激动剂,对人和大鼠的 Kis 分别为 8.7 nM 和 9.8 nM。 Samelisant 具有抗猝倒作用,可用于关于发作性睡病的研究。
规格 | 价格/CNY | 货期 | 数量 | |
---|---|---|---|---|
1 mg | ¥ 1,180 | 现货 | ||
2 mg | ¥ 1,750 | 现货 | ||
5 mg | ¥ 2,890 | 现货 | ||
10 mg | ¥ 4,360 | 现货 | ||
25 mg | ¥ 6,960 | 现货 | ||
50 mg | ¥ 9,380 | 现货 | ||
100 mg | ¥ 12,600 | 现货 | ||
500 mg | ¥ 25,300 | 现货 | ||
1 mL * 10 mM (in DMSO) | ¥ 3,180 | 现货 |
产品描述 | Samelisant (SUVN-G3031) is a selective and inverse agonist of H3 receptor with Kis of 8.7 nM and 9.8 nM for human and rat. Samelisant has anticataplectic effects and can be used in studies about narcolepsy. |
体外活性 | Samelisant (1, 10, and 100 nM) increases the pEC50 from 8.5 to 8.2, 7.3, and 6.2 for human H3 receptor and from 8.2 to 7.9, 7.4, and 6.4 for rat H3 receptor, respectively. Samelisant modulates dopamine and norepinephrine levels in the cerebral cortex. Samelisant reversibly binds to the orthosteric site with Kbs of 1.3 nM and 1.1 nM[1]. |
体内活性 | In orexin knockout mice subjected to sleep EEG, Samelisant (10 and 30 mg/kg; p.o.) significantly increases wakefulness and concomitantly decreases NREM sleep. Samelisant significantly decreases direct REM sleep onset episodes and dose-dependently increases the level of tele-methylhistamine[1]. |
别名 | SUVN-G3031 |
分子量 | 373.49 |
分子式 | C21H31N3O3 |
CAS No. | 1394808-82-2 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 50 mg/mL (112.01 mM), Sonication and heating to 60℃ are recommended.
可选溶剂 | 浓度 体积 质量 | 1 mg | 5 mg | 10 mg | 25 mg |
DMSO | 1 mM | 2.6774 mL | 13.3872 mL | 26.7745 mL | 66.9362 mL |
5 mM | 0.5355 mL | 2.6774 mL | 5.3549 mL | 13.3872 mL | |
10 mM | 0.2677 mL | 1.3387 mL | 2.6774 mL | 6.6936 mL | |
20 mM | 0.1339 mL | 0.6694 mL | 1.3387 mL | 3.3468 mL | |
50 mM | 0.0535 mL | 0.2677 mL | 0.5355 mL | 1.3387 mL | |
100 mM | 0.0268 mL | 0.1339 mL | 0.2677 mL | 0.6694 mL |
对于不同动物的给药剂量换算,您也可以参考 更多...
请在以下方框中输入您的动物实验信息后点击计算,可以得到母液配置方法和体内配方的制备方法: 比如您的给药剂量是10 mg/kg,每只动物体重20 g,给药体积100 μL,一共给药动物10 只,您使用的配方为5% DMSO+30% PEG300+5% Tween 80+60% ddH2O。那么您的工作液浓度为2 mg/mL。
母液配置方法:2 mg 药物溶于 50 μL DMSO (母液浓度为 40 mg/mL), 如您需要配置的浓度超过该产品的溶解度,请先与我们联系。
体内配方的制备方法:取 50 μL DMSO 主液,加入 300 μL PEG300, 混匀澄清,再加 50 μL Tween 80,混匀澄清,再加 600 μL ddH2O, 混匀澄清。
您可能有的问题的答案可以在抑制剂处理说明中找到,包括如何准备库存溶液,如何存储产品,以及基于细胞的分析和动物实验需要特别注意的问题。
Samelisant 1394808-82-2 GPCR/G Protein Immunology/Inflammation Neuroscience Histamine Receptor SUVN-G3031 SUVN-G 3031 SUVN-G-3031 Inhibitor inhibitor inhibit