neprilysin

Racecadotril (Acetorphan) 是一种中性内肽酶 (NEP) 抑制剂，具有止泻作用。Racecadotril 及其活性代谢物 Thiorphan 抑制小鼠脑中纯化的NEP 活性，Ki 分别为 4500 和 6.1 nM。

Sacubitril/Valsartan (LCZ696)，以1:1摩尔比由Valsartan（一种ARB）和Sacubitril（AHU377）组成，为创新口服血管紧张素受体-脑啡肽酶（ARN）双重抑制剂，旨在治疗高血压与心力衰竭。其作用机制包括抑制炎症、氧化应激及细胞凋亡，有助于改善糖尿病心肌病。

Sacubitril hemicalcium salt (AHU377 calcium salt) 是一种有效的 NEP 抑制剂，IC50=5 nM。它是研究心力衰竭药物 LCZ696 的组分之一。

Sacubitril (AHU-377) 是一种有效的NEP 抑制剂，IC50=5 nM。它是研究心力衰竭药物 LCZ696 的组分之一。

Phosphoramidon Disodium (Phosphoramidon Disodium Salt) Salt 是一种金属蛋白酶 (metalloprotease) 抑制剂 。Phosphoramidon Disodium Salt 抑制内皮素转化酶 (ECE) ，中性肽内切酶 (NEP) 和血管紧张素转换酶 (ACE) 的IC50分别为 3.5 ，0.034 和 78 μM。

Thiorphan 是选择性neprilysin 抑制剂 (IC50:6.9 nM) 。

Sacubitrilat (LBQ-657) 是活性的脑啡肽酶 (NEP) 抑制剂。

Potent somatostatin receptor 1 (sst1) agonist; displays selectivity for sst1 (IC50 values are 30.9 nM, 345 nM, > 1 μM, > 10 μM and > 10μM for human sst1, sst3, sst4, sst2 and sst5 respectively). Attenuates somatostatin release in the rat nucleus accumbens

Candoxatril (UK 79300) 是具有口服活性的中性肽链内切酶 (NEP，EC 3.4.24.11) 抑制剂，可改善接受血管紧张素转换酶抑制的慢性心力衰竭患者的运动能力。

NEP-IN-1 是中性肽链内切酶 (NEP) 的抑制剂 (IC50 = 2 nM)。

Sacubitril sodium (沙库必曲钠盐,AHU377)是一种有效的NEP抑制剂，IC50=5 nM，可治疗心力衰竭或者作为降压药联用。

TD-0212 is an orally active dual pharmacology antagonist of angiotensin II type 1 receptor (AT1) and inhibitor of neprilysin (NEP)(pKi of 8.9 for AT1 and a pIC50 of 9.2 for NEP).

TD-0212 TFA is an orally active dual pharmacology antagonist of angiotensin II type 1 receptor (AT1) and inhibitor of neprilysin (NEP)(pKi of 8.9 for AT1 and a pIC50 of 9.2 for NEP).

Racecadotril-d5 is intended for use as an internal standard for the quantification of racecadotril by GC- or LC-MS. Racecadotril is a prodrug form of the neprilysin (NEP) inhibitor thiorphan. In vivo, racecadotril reduces or prevents castor oil-induced diarrhea without delaying intestinal transit in rats when administered at doses of 80 or 100 mg/kg, respectively. It also decreases the duration of diarrhea and increases body weight gain in a neonatal gnotobiotic pig model of human rotavirus-induced diarrhea. Formulations containing racecadotril have been used in the treatment of acute diarrhea.

SCH 42495 is an orally active neutral metalloendopeptidase inhibitor. SCH 42495 is the orally active ethyl ester prodrug of SCH 42354.

SCH 42495 racemate is the racemate of SCH 42495. SCH 42495 is an orally active neutral inhibitor of metalloendopeptidase (NEP), with antihypertensive effect.

SQ28603 is a potent and selective neutral endopeptidase 3.4.24.11 (NEP) inhibitor.

NEP-IN-2 is an inhibitor of neutral endopeptidase. It also is used in the research of proliferation in atherosclerosis, restenosis.

Sampatrilat is an effecive and orally active vasopeptidase inhibitor of ACE and neutral endopeptidase. Sampatrilat inhibits C-domain ACE (Ki=13.8 nM) 12.4-fold more potent than that for the N-domain (Ki=171.9 nM).

LHW090-A7 是一种中性肽链内切酶 (NEP) 抑制剂，是一种负责脑啡肽代谢失活的酶。

JA2作为金属内切肽酶24.15的抑制剂，能够提升大鼠对缓激肽引发的降血压反应。

Phosphoramidon is a membrane metallo-endopeptidase & endothelin-converting enzyme inhibitor and thermolysin inhibitor, which is obtained from culture filtrate of Streptomyces tanashiensis.

SDUY817 是一种双重APN/NEP抑制剂，其对APN和NEP的抑制常数IC50值分别为 0.29 μM 和 7.4 μM。在浓度和时间依赖性条件下，SDUY817 展现出镇痛效果，可应用于神经性疼痛疾病的研究领域。

SDUY816 是口服活性的双重APN/NEP抑制剂，对APN和NEP的IC50分别为0.68 μM和6.9 μM。其具有镇痛效果，安全性良好，并具备优良的药代动力学特性。在大鼠中（口服，10 mg/kg），SDUY816 的生物利用度为27%，半衰期为4.02小时。该化合物适用于神经性疼痛疾病的研究。