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Fexofenadine

Name: Fexofenadine
Brand: TargetMol
SKU: T21390
Price: 255 CNY
Availability: InStock
Rating: 5 (10 reviews)

一键复制产品信息

很棒

纯度: 99.35%

货号 T21390Cas号 83799-24-0

别名 非索非那定, Telfast, MDL 16.455, Carboxyterfenadine, Allegra

Fexofenadine (Carboxyterfenadine) 是一种抗组胺药物，用于治疗过敏症状，如鼻塞、花粉热和荨麻疹。与第一代抗组胺药相比，它通过血脑屏障并引起镇静的能力较差。

Fexofenadine

一键复制产品信息

很棒

纯度: 99.35%

货号 T21390 别名 非索非那定, Telfast, MDL 16.455, Carboxyterfenadine, AllegraCas号 83799-24-0

规格	价格	库存
5 mg	¥ 255	现货
10 mg	¥ 418	现货
25 mg	¥ 668	现货
50 mg	¥ 974	现货
100 mg	¥ 1,442	现货
500 mg	¥ 3,734	现货
1 mL x 10 mM (in DMSO)	¥ 292	现货

库存状态实时更新，以官网显示为准，现货产品可直接加购物车下单

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实验操作小课堂

常见问题解答

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纯度: 99.35%

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资源下载:

COA LCMS HNMR HPLC 产品操作手册

产品介绍

Fexofenadine AI Summary

Fexofenadine exhibits a range of bioactivities including significant inhibition of the human voltage-gated potassium channel subunit Kv11.1 (ERG K+ channel) in multiple cell types such as HEK293 and CHO cells, with IC50 values ranging from 21379.62 nM to 23000.0 nM. It demonstrates significant lipophilicity characterized by LogD values between 1.85 and 2.3, moderate permeability across human Caco-2 cells, and various levels of binding to plasma proteins across different species. The compound shows potent antihistaminic activity, inhibiting the histamine H1 receptor with an IC50 value of 78.0 nM and exhibits anti-inflammatory properties in murine models. Additionally, it shows transporter substrate activity, which includes specific affinities to transporters like OATP, and demonstrates both high bioavailability and moderate liver metabolism. Fexofenadine also shows antiviral activity against SARS-CoV-2 and various antimicrobial properties, although its inhibition of enzymes like CYP2J2 is weak. It has been noted for moderate liver toxicity, and specific interactions with human liver transporters such as OATP2B1, OATP1B3, and OATP1B1 indicate its involvement in hepatic drug uptake and excretion processes. These findings suggest that Fexofenadine has potential therapeutic applications, particularly in addressing cardiovascular, inflammatory, and potentially antiviral conditions..

Note: Summary generated by AI. Data source: ChEMBL

生物活性

产品描述	Fexofenadine (Carboxyterfenadine), an antihistamine pharmaceutical drug, is used to treat allergy symptoms, such as nasal congestion, hay fever, and urticaria. Compared to first-generation antihistamines, Fexofenadine is less able to pass the blood-brain barrier and cause sedation.
别名	非索非那定, Telfast, MDL 16.455, Carboxyterfenadine, Allegra

化学信息

分子量	501.66
分子式	C₃₂H₃₉NO₄
CAS No.	83799-24-0
Smiles	CC(C)(C(O)=O)c1ccc(cc1)C(O)CCCN1CCC(CC1)C(O)(c1ccccc1)c1ccccc1
密度	1.171 g/cm3

储存&溶解度

存储

In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

溶解度信息

DMSO: 10.64 mg/mL (21.21 mM), Sonication is recommended.

H2O: Insoluble

溶液配制表

DMSO

	1mg	5mg	10mg	50mg
1 mM	1.9934 mL	9.9669 mL	19.9338 mL	99.6691 mL
5 mM	0.3987 mL	1.9934 mL	3.9868 mL	19.9338 mL
10 mM	0.1993 mL	0.9967 mL	1.9934 mL	9.9669 mL
20 mM	0.0997 mL	0.4983 mL	0.9967 mL	4.9835 mL

计算器

摩尔浓度计算器
稀释计算器
配液计算器
分子量计算器

体内实验配液计算器

请在以下方框中输入您的动物实验信息后点击计算，可以得到母液配置方法和体内配方的制备方法：

比如您的给药剂量是10 mg/kg，每只动物体重20 g，给药体积100 μL，一共给药动物10只，您使用的配方为 10% DMSO + 40% PEG300 + 5% Tween 80 + 45% Saline / PBS / ddH₂O，那么您的工作液浓度为2 mg/mL。

母液配置方法：2 mg 药物溶于 100 μL DMSO （母液浓度为 20 mg/mL ）, 如您需要配置的浓度超过该产品的溶解度，请先与我们联系。

体内配方的制备方法： 取 100 μL DMSO 母液，添加 400 μL PEG300 混匀澄清，再加 50 μL Tween 80, 混匀澄清, 再加 450 μL Saline / PBS / ddH₂O 混匀澄清

以上为“体内实验配液计算器”的使用方法举例，并不是具体某个化合物的推荐配制方式，请根据您的实验动物和给药方式选择适当的溶解方案。

方案所需的各类助溶剂如： DMSO， PEG300， PEG400， Tween 80， SBE-β-CD，玉米油等，均可在TargetMol网站点击购买。

剂量转换

对于不同动物的给药剂量换算，您也可以参考更多

关键词

HistamineReceptor Histamine Receptor Fexofenadine

Fexofenadine

Fexofenadine

Fexofenadine 相关产品

产品介绍

计算器

体内实验配液计算器

剂量转换

引用文献

关键词