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Fexofenadine hydrochloride

Name: Fexofenadine hydrochloride
Brand: TargetMol
SKU: T1470L
Rating: 4.5 (1 reviews)

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货号 T1470LCas号 138452-21-8

Fexofenadine hydrochloride 是 terfenadine 的羧化代谢衍生物和长效选择性组胺 H1 受体拮抗剂，具有抗组胺活性。

Fexofenadine hydrochloride

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货号 T1470LCas号 138452-21-8

Fexofenadine hydrochloride 是 terfenadine 的羧化代谢衍生物和长效选择性组胺 H1 受体拮抗剂，具有抗组胺活性。

规格	价格	库存
5 mg	¥ 192	5日内发货
10 mg	¥ 336	5日内发货
25 mg	¥ 663	5日内发货
50 mg	¥ 997	5日内发货
100 mg	¥ 1,380	5日内发货
200 mg	¥ 1,950	5日内发货
1 mL x 10 mM (in DMSO)	¥ 277	5日内发货

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TargetMol的所有产品仅用作科学研究或药证申报，不能被用于人体，我们不向个人提供产品和服务。请您遵守承诺用途，不得违反法律法规规定用于任何其他用途。

实验操作小课堂

常见问题解答

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纯度: >99.99%

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产品介绍

Fexofenadine hydrochloride AI Summary

Fexofenadine hydrochloride has shown a broad spectrum of bioactivities and pharmacokinetic properties. It exhibits potent antiplasmodial activity against Plasmodium falciparum W2 with an IC50 value of 10000.0 nM and demonstrates inhibitory effects on enzymes like 15-human lipoxygenase (19952.6 nM), Hydroxyacyl-Coenzyme A Dehydrogenase, Type II (3162.3 nM), and Mammalian Selenoprotein Thioredoxin Reductase 1 (TrxR1) (89125.1 nM). Additionally, it modulates Lamin A splicing with a potency of 251.2 nM and induces DNA re-replication in SW480 colon adenocarcinoma cells at 1835.6 nM. The compound also demonstrates antiviral properties, including blocking the entry of the Ebola Virus (AC50 ranging from 631.0 nM to 1.259 µM) and inhibiting SARS-CoV-2 replication. In terms of pharmacokinetics, it maintains good metabolic stability in human serum and exhibits varying maximum plasma concentrations (Cmax) and times to reach maximum concentration (Tmax) when administered with pseudoephedrine hydrochloride, indicating effective bioavailability and absorption. Fexofenadine hydrochloride has relatively low solubility in water but higher solubility in simulated gastric and intestinal fluids, enhancing its bioavailability under physiological conditions. It shows antifungal activity against Candida albicans and Cryptococcus neoformans and antibacterial activity against multiple strains including Escherichia coli and Klebsiella pneumoniae. Furthermore, the compound affects cell viability across different cell lines and demonstrates both slight destabilization and stabilization of protein domains, indicating its potential for protein interaction modulation. It also exhibits a range of bioactivities in GPCR beta-arrestin recruitment assays, influencing various physiological processes through different receptor pathways. Overall, Fexofenadine hydrochloride is characterized by its diverse bioactivities, stability, and pharmacokinetic properties, making it a compound of interest for further pharmacological and biochemical studies..

Note: Summary generated by AI. Data source: ChEMBL

生物活性

产品描述	Fexofenadine Hydrochloride is a carboxylated metabolic derivative of terfenadine and long-lasting selective histamine H1 receptor antagonist, with antihistaminic activity.

化学信息

分子量	538.12
分子式	C₃₂H₄₀ClNO₄
CAS No.	138452-21-8
Smiles	Cl.O=C(O)C(C1=CC=C(C=C1)C(O)CCCN2CCC(CC2)C(O)(C=3C=CC=CC3)C=4C=CC=CC4)(C)C
密度	no data available

储存&溶解度

存储

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

溶解度信息

DMSO: 55 mg/mL (102.21 mM), Sonication is recommended.

溶液配制表

DMSO

	1mg	5mg	10mg	50mg
1 mM	1.8583 mL	9.2916 mL	18.5832 mL	92.9161 mL
5 mM	0.3717 mL	1.8583 mL	3.7166 mL	18.5832 mL
10 mM	0.1858 mL	0.9292 mL	1.8583 mL	9.2916 mL
20 mM	0.0929 mL	0.4646 mL	0.9292 mL	4.6458 mL
50 mM	0.0372 mL	0.1858 mL	0.3717 mL	1.8583 mL
100 mM	0.0186 mL	0.0929 mL	0.1858 mL	0.9292 mL

计算器

摩尔浓度计算器
稀释计算器
配液计算器
分子量计算器

体内实验配液计算器

请在以下方框中输入您的动物实验信息后点击计算，可以得到母液配置方法和体内配方的制备方法：

比如您的给药剂量是10 mg/kg，每只动物体重20 g，给药体积100 μL，一共给药动物10只，您使用的配方为 10% DMSO + 40% PEG300 + 5% Tween 80 + 45% Saline / PBS / ddH₂O，那么您的工作液浓度为2 mg/mL。

母液配置方法：2 mg 药物溶于 100 μL DMSO （母液浓度为 20 mg/mL ）, 如您需要配置的浓度超过该产品的溶解度，请先与我们联系。

体内配方的制备方法： 取 100 μL DMSO 母液，添加 400 μL PEG300 混匀澄清，再加 50 μL Tween 80, 混匀澄清, 再加 450 μL Saline / PBS / ddH₂O 混匀澄清

以上为“体内实验配液计算器”的使用方法举例，并不是具体某个化合物的推荐配制方式，请根据您的实验动物和给药方式选择适当的溶解方案。

方案所需的各类助溶剂如： DMSO， PEG300， PEG400， Tween 80， SBE-β-CD，玉米油等，均可在TargetMol网站点击购买。

剂量转换

对于不同动物的给药剂量换算，您也可以参考更多

关键词

HistamineReceptor Histamine Receptor H1 receptor Fexofenadine hydrochloride

Fexofenadine hydrochloride

Fexofenadine hydrochloride