购物车

您的购物车当前为空

Cetirizine dihydrochloride

Name: Cetirizine dihydrochloride
Brand: TargetMol
SKU: T0089
Price: 289 CNY
Availability: InStock
Rating: 5 (10 reviews)

一键复制产品信息

很棒

纯度: 99.97%

货号 T0089Cas号 83881-52-1

别名 盐酸西替利嗪, UCB P071, P071, Cetirizine DiHCl

Cetirizine dihydrochloride (UCB P071) 是羟嗪的羧化代谢物，是特异性口服有效的 H1 受体长效拮抗剂。它标记抗过敏特性，抑制过敏反应期间嗜酸性粒细胞趋化，可有效治疗过敏性鼻炎、确诊荨麻疹和花粉诱发的哮喘。

Cetirizine dihydrochloride

一键复制产品信息

很棒

纯度: 99.97%

货号 T0089 别名 盐酸西替利嗪, UCB P071, P071, Cetirizine DiHClCas号 83881-52-1

规格	价格	库存
50 mg	¥ 289	现货
100 mg	¥ 398	现货
200 mg	¥ 672	现货
500 mg	¥ 955	现货
1 mL x 10 mM (in DMSO)	¥ 448	现货

库存状态实时更新，以官网显示为准，现货产品可直接加购物车下单

大包装 & 定制

加入购物车

TargetMol的所有产品仅用作科学研究或药证申报，不能被用于人体，我们不向个人提供产品和服务。请您遵守承诺用途，不得违反法律法规规定用于任何其他用途。

实验操作小课堂

常见问题解答

选择批次:

纯度: 99.97%

联系我们获取更多批次信息

资源下载:

COA LCMS HNMR 产品操作手册

产品介绍

Cetirizine dihydrochloride AI Summary

Cetirizine dihydrochloride exhibits a diverse range of bioactivities across various assays and targets. It shows significant potency in inhibiting the interaction between CBF-beta and RUNX1 with potencies ranging from 791.1 nM to 4991.7 nM, suggesting potential for the treatment of Acute Myeloid Leukemia. It also inhibits Histone Lysine Methyltransferase G9a at 23778.1 nM, T. brucei phosphofructokinase at 37933.0 nM, human tyrosyl-DNA phosphodiesterase 1 (TDP1) with potencies ranging from 14581.0 nM to 29092.9 nM, and Human Apurinic/apyrimidinic Endonuclease 1 (APE1) at 19952.6 nM. Additionally, the compound blocks Ebola Virus entry with AC50 values ranging from 398.1 nM to 12.59 uM, and inhibits sodium fluorescein uptake in OATP1B3- and OATP1B1-transfected CHO cells by 78.28% and 76.54%, respectively, at a concentration of 10 uM. Regarding antiviral activities, Cetirizine dihydrochloride shows low activity against SARS-CoV-2 in Vero E6 cells with an inhibition index of 0.09157 but exhibits stronger inhibition on SARS-CoV-2 induced cytotoxicity in Caco-2 cells (0.62% inhibition at 10 uM) and complete inhibition in VERO-6 cells at 10 uM after 48 hours of exposure. Additionally, the compound inhibits SARS-CoV-2 3CL-Pro protease by approximately 1.185% at 20 µM. Overall, Cetirizine dihydrochloride demonstrates a wide spectrum of biological activities, including notable effects on leukemia-related targets, various enzymes, and antiviral properties against Ebola Virus and SARS-CoV-2..

Note: Summary generated by AI. Data source: ChEMBL

生物活性

产品描述	Cetirizine dihydrochloride (UCB P071) is an effective second-generation histamine H1 antagonist that is potent in the therapy of allergic rhinitis, confirmed urticaria, and pollen-induced asthma. Unlike other conventional antihistamines, it does not cause side effects of drowsiness or anticholinergic.
别名	盐酸西替利嗪, UCB P071, P071, Cetirizine DiHCl

化学信息

分子量	461.81
分子式	C₂₁H₂₇Cl₃N₂O₃
CAS No.	83881-52-1
Smiles	Cl.Cl.OC(=O)COCCN1CCN(CC1)C(c1ccccc1)c1ccc(Cl)cc1
密度	1.237 g/cm3

储存&溶解度

存储

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

溶解度信息

H2O: 46.2 mg/mL (100.04 mM), Sonication is recommended.

DMSO: 55 mg/mL (119.1 mM), Sonication is recommended.

体内实验配方

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (4.33 mM), Sonication is recommended.

请按顺序添加溶剂，在添加下一种溶剂之前，尽可能使溶液澄清。如有必要，可通过加热、超声、涡旋处理进行溶解。工作液建议现配现用。以上配方仅供参考，体内配方并不是绝对的，请根据不同情况进行调整。

溶液配制表

H2O/DMSO

	1mg	5mg	10mg	50mg
1 mM	2.1654 mL	10.8270 mL	21.6539 mL	108.2696 mL
5 mM	0.4331 mL	2.1654 mL	4.3308 mL	21.6539 mL
10 mM	0.2165 mL	1.0827 mL	2.1654 mL	10.8270 mL
20 mM	0.1083 mL	0.5413 mL	1.0827 mL	5.4135 mL
50 mM	0.0433 mL	0.2165 mL	0.4331 mL	2.1654 mL
100 mM	0.0217 mL	0.1083 mL	0.2165 mL	1.0827 mL

计算器

摩尔浓度计算器
稀释计算器
配液计算器
分子量计算器

体内实验配液计算器

请在以下方框中输入您的动物实验信息后点击计算，可以得到母液配置方法和体内配方的制备方法：

比如您的给药剂量是10 mg/kg，每只动物体重20 g，给药体积100 μL，一共给药动物10只，您使用的配方为 10% DMSO + 40% PEG300 + 5% Tween 80 + 45% Saline / PBS / ddH₂O，那么您的工作液浓度为2 mg/mL。

母液配置方法：2 mg 药物溶于 100 μL DMSO （母液浓度为 20 mg/mL ）, 如您需要配置的浓度超过该产品的溶解度，请先与我们联系。

体内配方的制备方法： 取 100 μL DMSO 母液，添加 400 μL PEG300 混匀澄清，再加 50 μL Tween 80, 混匀澄清, 再加 450 μL Saline / PBS / ddH₂O 混匀澄清

以上为“体内实验配液计算器”的使用方法举例，并不是具体某个化合物的推荐配制方式，请根据您的实验动物和给药方式选择适当的溶解方案。

方案所需的各类助溶剂如： DMSO， PEG300， PEG400， Tween 80， SBE-β-CD，玉米油等，均可在TargetMol网站点击购买。

剂量转换

对于不同动物的给药剂量换算，您也可以参考更多

关键词

UCB P-071 UCB P 071 Seasonal SAR rhinitis P-071 P 071 HistamineReceptor Histamine Receptor H1 receptor GM-CSF Cetirizine allergic

Cetirizine dihydrochloride

Cetirizine dihydrochloride