keep away from direct sunlight | Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Camlipixant (BLU-5937) 是一种具有口服活性的嘌呤P2X3受体拮抗剂,具有有效性、选择性和竞争性。Camlipixant 对 hP2X3 同型三聚体的 IC50 为 25 nM。Camlipixant 可用于治疗呼吸系统疾病和免疫系统疾病,研究难治性慢性咳嗽和特应性皮炎。Camlipixant 具有较强的止咳效果。
规格 | 价格/CNY | 货期 | 数量 | |
---|---|---|---|---|
1 mg | ¥ 997 | 现货 | ||
5 mg | ¥ 2,390 | 现货 | ||
10 mg | ¥ 3,890 | 现货 | ||
25 mg | ¥ 6,850 | 现货 | ||
50 mg | ¥ 9,270 | 现货 | ||
100 mg | ¥ 12,500 | 现货 | ||
1 mL * 10 mM (in DMSO) | ¥ 2,430 | 现货 |
产品描述 | Camlipixant (BLU-5937) is an orally active purine P2X3 receptor antagonist that is potent, selective and competitive. camlipixant has an IC50 of 25 nM for the hP2X3 homotrimer. camlipixant can be used for the treatment of respiratory disorders and Camlipixant has a strong cough suppressant effect. |
靶点活性 | P2X3 (human):25 nM, P2X3 (rat):92 nM, P2X2/3 (rat):1820 nM, P2X3 (guinea pig):126 nM, P2X2/3 (guinea pig):3450 nM |
体外活性 | Camlipixant (BLU-5937 ; 500 nM) blocks ATP-mediated sensitization of dorsal root ganglion (DRG) neurons.[1] |
体内活性 |
Camlipixant (BLU-5937 ; 3-30 mg/kg ; oral) reduces histamine and ATP-induced cough sensitization in guinea pigs.[1]
Camlipixant (BLU-5937 ; 10-20 mg/kg ; i.p.) did not alter taste perception compared to control animals.[1] Camlipixant (BLU-5937) exhibits excellent drug-like properties, including good oral bioavailability, low predicted clearance in humans, no blood-brain barrier permeability, and high safety.[1] |
别名 | BLU-5937 |
分子量 | 458.46 |
分子式 | C23H24F2N4O4 |
CAS No. | 1621164-74-6 |
keep away from direct sunlight | Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 22.5 mg/mL (49.08 mM)
可选溶剂 | 浓度 体积 质量 | 1 mg | 5 mg | 10 mg | 25 mg |
DMSO | 1 mM | 2.1812 mL | 10.9061 mL | 21.8122 mL | 54.5304 mL |
5 mM | 0.4362 mL | 2.1812 mL | 4.3624 mL | 10.9061 mL | |
10 mM | 0.2181 mL | 1.0906 mL | 2.1812 mL | 5.453 mL | |
20 mM | 0.1091 mL | 0.5453 mL | 1.0906 mL | 2.7265 mL |
对于不同动物的给药剂量换算,您也可以参考 更多...
请在以下方框中输入您的动物实验信息后点击计算,可以得到母液配置方法和体内配方的制备方法: 比如您的给药剂量是10 mg/kg,每只动物体重20 g,给药体积100 μL,一共给药动物10 只,您使用的配方为5% DMSO+30% PEG300+5% Tween 80+60% ddH2O。那么您的工作液浓度为2 mg/mL。
母液配置方法:2 mg 药物溶于 50 μL DMSO (母液浓度为 40 mg/mL), 如您需要配置的浓度超过该产品的溶解度,请先与我们联系。
体内配方的制备方法:取 50 μL DMSO 主液,加入 300 μL PEG300, 混匀澄清,再加 50 μL Tween 80,混匀澄清,再加 600 μL ddH2O, 混匀澄清。
您可能有的问题的答案可以在抑制剂处理说明中找到,包括如何准备库存溶液,如何存储产品,以及基于细胞的分析和动物实验需要特别注意的问题。
Camlipixant 1621164-74-6 Membrane transporter/Ion channel Neuroscience P2X Receptor BLU5937 BLU 5937 BLU-5937 Inhibitor inhibitor inhibit