debio-1452

AFN-1252 (Debio 1452)是一种FabI 的高效抑制剂，能抑制金黄色葡萄球菌。

AMPCP is an Ecto-5'-nucleotidase (CD73) inhibitor.

Debio-1452-NH3作为一种新型高效的FabI抗体—烯酰基载体蛋白还原酶抑制剂，在减轻小鼠体内细菌负担方面表现出色，并能有效救治因临床分离株的铜绿假单胞菌（Acinetobacter baumannii）、肺炎克雷伯菌（Klebsiella pneumoniae）及大肠杆菌（E. coli）引起的致命感染。

AFN-1252, also known as AFN-12520000; API-1252; Debio-1452, is FASII Inhibitor which is potentially for the treatment of acute bacterial skin. AFN-1252 exhibits typical MIC(90) values of ≤0·015 μg ml against diverse clinical isolates of S. aureus, oral absorption, long elimination half-live and efficacy in animal models. AFN-1252 efficiently blocked daptomycin-induced phospholipid decoy production, even in the case of isolates resistant to AFN-1252, which prevented the inactivation of daptomycin and resulted in sustained bacterial killing. In turn, daptomycin prevented the fatty acid-dependent emergence of AFN-1252-resistant isolates in vitr