acridone

Acridone 具有抗菌、抗疟、抗病毒和抗肿瘤活性。它可诱导细胞凋亡，抑制 ABCG2 蛋白，并调节激素水平。

3,6-Diamino-9(10H)-acridone 是拓扑异构酶的抑制剂。

Acridone-4-carboxylic acid (ACA) (Compound 2c) 是一种 acridone 衍生物，可与血红素相互作用，阻断游离血红素介导的蛋白质氧化和降解。Acridone-4-carboxylic acid 抑制蛋白质羰基形成，IC50为 43 μM。

1,3-Dihydroxy-10-methylacridone 是一种有用的有机化合物，可用于生命科学领域的相关研究，其产品编号为 T131490。

1,7-Dihydroxyacridone, a natural product from *Boenninghausenia albiflora*.

1-Hydroxy-N-methylacridone is a natural product from Ruta chalepensis.

Rutacridone has mutagenicity.

1-Hydroxyacridone has potential antiviral activity.

1,3-Dihydroxy-2,4-diprenylacridone 是一种天然产物，可用于生命科学领域的相关研究。其产品编号为 TN6171，CAS号为 1205687-48-4。

10-methyl-9-(phenoxycarbonyl) Acridinium 是一种吖啶鎓酯，在碱性条件下与过氧化氢、过硫酸盐和其他氧化剂氧化后会产生荧光 10-methyl-9-acridone。

STING IN 42 具有STING抑制活性、可以阻断STING蛋白的棕榈酰化和STING下游信号传导。STING IN 42 具有较好的的药代动力学特性，能口服有效抑制10-羧甲基-9-吖啶酮（CMA）治疗的小鼠和Trex1- -小鼠中STING介导的炎症。

Atalaphillinine is an acridone alkaloid.

5,7,8-Trimethoxydictamnine is a quinoline alkaloid that has been found inRutaceaeand has antimalarial activity.1It is active against chloroquine-sensitive and -resistant strains ofP. falciparum(IC50s =19.9 and 5.72 μg/ml, respectively). 1.Basco, L.K.M., S., Skaltsounis, A.-L., Ravvelomanantsoa, N., et al.In vitro activities of furoquinoline and acridone alkaloids against Plasmodium falciparumAntimicrob. Agents Chemother.38(5)1169-1171(1994)

Evoxanthine is an alkaloid that has been found in O. renieri and has antimalarial and anticancer activities.1,2 It is active against P. falciparum with an IC50 value of 67.6 μg ml.1 Evoxanthine decreases proliferation of nine sensitive and drug-resistant cancer cell lines (IC50s = 6.11-80.99 μM).2 |1. Khalid, S.A., Farouk, A., Geary, T.G., et al. Potential antimalarial candidates from African plants: And in vitro approach using Plasmodium falciparum. J. Ethnopharmacol. 15(2), 201-209 (1986).|2. Kuete, V., Fouotsa, H., Mbaveng, A.T., et al. Cytotoxicity of a naturally occurring furoquinoline alkaloid and four acridone alkaloids towards multi-factorial drug-resistant cancer cells. Phytomedicine 22(10), 946-951 (2015).

STING agonist 12b is an agonist of stimulator of interferon genes (STING).1It binds to STING (Kd= 26.4 μM) and induces interferon reporter gene expression in cells expressing human or mouse STING (EC50s = 7.45 and 10.23 μM, respectively). STING agonist 12b (40 μM) induces expression of TNF-a, IL-6, IP-10, and IL-1b in THP-1 cells. 1.Hou, S., Lan, X.-j., Li, W., et al.Design, synthesis and biological evaluation of acridone analogues as novel STING receptor agonistsBioorg. Chem.95103556(2020)

Topoisomerase II inhibitor 3 (Compound 6 h) is an acridone derivative that acts as a Type II DNA topoisomerase (topo II) inhibitor. It specifically inhibits the topo IIα β subtypes, with an IC50 value of 0.17 μM for topo IIα and 0.23 μM for topo IIβ. This compound elicits significant DNA damage and induces apoptosis by triggering the loss of mitochondrial membrane potential [1].

ER-27319为吖啶酮衍生物，高效选择性抑制SYK，阻断其酪氨酸磷酸化和活性。本化合物阻止抗原刺激下人及大鼠肥大细胞释放过敏介质，IC50约为10 μM，适用于过敏性疾病研究。