Powder: -20°C for 3 years | In solvent: -80°C for 1 year
LOX-IN-3 dihydrochloride 是口服有效的赖氨酰氧化酶抑制剂,在纤维化,癌症和/或血管生成方面有研究价值。
规格 | 价格/CNY | 货期 | 数量 | |
---|---|---|---|---|
1 mg | ¥ 1,260 | 现货 | ||
5 mg | ¥ 3,160 | 现货 | ||
10 mg | ¥ 4,680 | 现货 | ||
25 mg | ¥ 7,380 | 现货 | ||
50 mg | ¥ 9,980 | 现货 | ||
100 mg | ¥ 13,300 | 现货 | ||
1 mL * 10 mM (in DMSO) | ¥ 3,180 | 现货 |
产品描述 | LOX-IN-3 dihydrochloride is an inhibitor of lysyl oxidase (LOX). LOX-IN-3 dihydrochloride inhibited bovine LOX (IC50<10 μM) and human LOXL2 (IC50<1 μM)activities. |
靶点活性 | LOX:<1 μM(human), LOX:<10 μM(bovine) |
体外活性 | LOX-IN-3 dihydrochloride can be used in fibrosis, cancer and angiogenesis studies. LOX-IN-3 dihydrochloride is less active against SSAO/VAP-1 and MAO-B activities[1]. |
体内活性 | LOX-IN-3 dihydrochloride (10 mg/kg, orally) treatment increases kidney weight and thickness and reduces the area of fibrosis In a 14-day unilateral ureteric obstruction (UUO) model[1]. LOX-IN-3 dihydrochloride (20 mg/kg i.p.) treatment significantly reduces liver fibrosis in BALB/c mice bearing hepatic fibrosis. At the end of week 4 a mouse breast cancer cell line (4tl) is injected orthotopically. LOX-IN-3 dihydrochloride treatment significantly reduced liver fibrosis, collagen cross-links and the metastatic load in the liver[1]. LOX-IN-3 dihydrochloride (30 mg/kg) completely abolished lysyl oxidase activity in young male Wistar rats. While plasma concentrations of LOX-IN-3 dihydrochloride were far below the IC50 after 8 hours, the half-life of recovery is between 2-3 days (ear) and 24 hours (aorta)[1]. |
分子量 | 353.24 |
分子式 | C13H15Cl2FN2O2S |
CAS No. | 2409964-23-2 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 55 mg/mL (155.71 mM)
可选溶剂 | 浓度 体积 质量 | 1 mg | 5 mg | 10 mg | 25 mg |
DMSO | 1 mM | 2.8309 mL | 14.1547 mL | 28.3094 mL | 70.7734 mL |
5 mM | 0.5662 mL | 2.8309 mL | 5.6619 mL | 14.1547 mL | |
10 mM | 0.2831 mL | 1.4155 mL | 2.8309 mL | 7.0773 mL | |
20 mM | 0.1415 mL | 0.7077 mL | 1.4155 mL | 3.5387 mL | |
50 mM | 0.0566 mL | 0.2831 mL | 0.5662 mL | 1.4155 mL | |
100 mM | 0.0283 mL | 0.1415 mL | 0.2831 mL | 0.7077 mL |
对于不同动物的给药剂量换算,您也可以参考 更多...
请在以下方框中输入您的动物实验信息后点击计算,可以得到母液配置方法和体内配方的制备方法: 比如您的给药剂量是10 mg/kg,每只动物体重20 g,给药体积100 μL,一共给药动物10 只,您使用的配方为5% DMSO+30% PEG300+5% Tween 80+60% ddH2O。那么您的工作液浓度为2 mg/mL。
母液配置方法:2 mg 药物溶于 50 μL DMSO (母液浓度为 40 mg/mL), 如您需要配置的浓度超过该产品的溶解度,请先与我们联系。
体内配方的制备方法:取 50 μL DMSO 主液,加入 300 μL PEG300, 混匀澄清,再加 50 μL Tween 80,混匀澄清,再加 600 μL ddH2O, 混匀澄清。
您可能有的问题的答案可以在抑制剂处理说明中找到,包括如何准备库存溶液,如何存储产品,以及基于细胞的分析和动物实验需要特别注意的问题。
LOX-IN-3 dihydrochloride 2409964-23-2 Metabolism Lipoxygenase LOX-IN-3 lysyl LOXIN3 dihydrochloride Inhibitor oxidase LOX-IN-3 Dihydrochloride MAO Monoamine Oxidase fibrosis inhibit LOXL2 LOX IN 3 dihydrochloride inhibitor