Powder: -20°C for 3 years | In solvent: -80°C for 1 year
BPAM344 是一种红藻氨酸受体亚基GluK1b、GluK2a 和GluK3a 的正变构调节剂。
规格 | 价格/CNY | 货期 | 数量 | |
---|---|---|---|---|
1 mg | ¥ 312 | 现货 | ||
5 mg | ¥ 872 | 现货 | ||
10 mg | ¥ 1,390 | 现货 | ||
25 mg | ¥ 2,970 | 现货 | ||
50 mg | ¥ 4,390 | 现货 | ||
100 mg | ¥ 6,280 | 现货 | ||
500 mg | ¥ 12,800 | 现货 | ||
1 mL * 10 mM (in DMSO) | ¥ 793 | 现货 |
产品描述 | BPAM344 is a potent positive allosteric modulator (PAM) of the KAR subunits GluK1b, GluK2a, and GluK3a. |
体外活性 | BPAM344 potentiated glutamate-evoked currents of GluK2a 21-fold at the highest concentration tested (200 μM), with an EC50 of 79 μM. BPAM344 markedly decreased desensitization kinetics (from 5.5 to 775 ms). BPAM521 potentiated the recorded peak current amplitude of GluK2a 12-fold at a concentration of 300 μM with an EC50 value of 159 μM. BPAM344 (100 μM) potentiated the peak current amplitude of KAR subunits GluK3a (59-fold), GluK2a (15-fold), GluK1b (5-fold), as well as the AMPA receptor subunit GluA1i (5-fold)[1]. |
分子量 | 242.27 |
分子式 | C10H11FN2O2S |
CAS No. | 1204572-55-3 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 55 mg/ml (227.02 mM)
可选溶剂 | 浓度 体积 质量 | 1 mg | 5 mg | 10 mg | 25 mg |
DMSO | 1 mM | 4.1276 mL | 20.6381 mL | 41.2763 mL | 103.1907 mL |
5 mM | 0.8255 mL | 4.1276 mL | 8.2553 mL | 20.6381 mL | |
10 mM | 0.4128 mL | 2.0638 mL | 4.1276 mL | 10.3191 mL | |
20 mM | 0.2064 mL | 1.0319 mL | 2.0638 mL | 5.1595 mL | |
50 mM | 0.0826 mL | 0.4128 mL | 0.8255 mL | 2.0638 mL | |
100 mM | 0.0413 mL | 0.2064 mL | 0.4128 mL | 1.0319 mL |
对于不同动物的给药剂量换算,您也可以参考 更多...
请在以下方框中输入您的动物实验信息后点击计算,可以得到母液配置方法和体内配方的制备方法: 比如您的给药剂量是10 mg/kg,每只动物体重20 g,给药体积100 μL,一共给药动物10 只,您使用的配方为5% DMSO+30% PEG300+5% Tween 80+60% ddH2O。那么您的工作液浓度为2 mg/mL。
母液配置方法:2 mg 药物溶于 50 μL DMSO (母液浓度为 40 mg/mL), 如您需要配置的浓度超过该产品的溶解度,请先与我们联系。
体内配方的制备方法:取 50 μL DMSO 主液,加入 300 μL PEG300, 混匀澄清,再加 50 μL Tween 80,混匀澄清,再加 600 μL ddH2O, 混匀澄清。
您可能有的问题的答案可以在抑制剂处理说明中找到,包括如何准备库存溶液,如何存储产品,以及基于细胞的分析和动物实验需要特别注意的问题。
BPAM344 1204572-55-3 Membrane transporter/Ion channel Neuroscience iGluR Ionotropic glutamate receptors GluK3a PAM Inhibitor KAR GluK1b BPAM 344 GluK2a inhibit BPAM-344 inhibitor