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EphA2 Protein, Human, Recombinant (aa 585-976, His & GST)

产品编号 TMPY-04427

别名: ARCC2, EPH receptor A2, CTPA, ECK, CTPP1, CTRCT6

EphA2 Protein, Human, Recombinant (aa 585-976, His & GST) is expressed in Baculovirus insect cells with His and GST tag. The predicted molecular weight is 72.1 kDa and the accession number is P29317.

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EphA2 Protein, Human, Recombinant (aa 585-976, His & GST)

规格	价格/CNY		货期	数量
50 μg	￥ 3,170		5日内发货

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生物活性	The specific activity was determined to be 50 nmol/min/mg using Poly(Glu:Tyr) 4:1 as substrate.
产品描述	EphA2 Protein, Human, Recombinant (aa 585-976, His & GST) is expressed in Baculovirus insect cells with His and GST tag. The predicted molecular weight is 72.1 kDa and the accession number is P29317.

种属	Human
表达系统	Baculovirus Insect Cells
标签	His, GST
蛋白编号	P29317
别名	ARCC2, EPH receptor A2, CTPA, ECK, CTPP1, CTRCT6
蛋白构建	The Human EPHA2 (P29317) (Leu585-Ile976) was fused with the N-terminal polyhistidine-tagged GST tag at the N-terminus.
蛋白纯度	> 95 % as determined by SDS-PAGE
分子量	72.1 kDa (predicted)

内毒素	< 1.0 EU/μg of the protein as determined by the LAL method.
缓冲液	Supplied as sterile 20 mM Tris, 500 mM NaCl, 3 mM DTT, pH 8.5, 10% gly.
复溶方法	A Certificate of Analysis (CoA) containing reconstitution instructions is included with the products. Please refer to the CoA for detailed information.
存储	It is recommended to store the product under sterile conditions at -20℃ to -80℃. Samples are stable for up to 12 months. Please avoid multiple freeze-thaw cycles and store products in aliquots.
运输方式	Kinases are highly recommended to be shipped at frozen temperature with blue ice or dry ice.
研究背景	Eph receptor A2 (Ephrin type-A receptor 2 or EphA2) is a member of the ephrin receptor subfamily of the protein-tyrosine kinase family. The Eph receptors' corresponding family of ligands are the ephrins anchored to cell surfaces. The ephrins and Eph receptors are implicated as positional labels that may guide the development of neural topographic maps. They have also been found implicated in embryonic patterning, neuronal targeting, vascular development and adult neovascularization. The large family of ligands and receptors may make a major contribution to the accurate spatial patterning of connections and cell position in the nervous system. Furthermore, elevated expression of Eph receptors and ephrin ligands is associated with tumors and associated tumor vasculature, suggesting the Eph receptors and ephrin ligands also play critical roles in tumor angiogenesis and tumor growth. Unlike most Eph kinases, which are primarily expressed during development, EphA2 is primarily found in adult human epithelial cells. The cellular functions of EphA2 may be regulating cell growth, survival, migration, and angiogenesis.Unlike other receptor tyrosine kinases, ligand binding is not necessary for EphA2. Rather, the ligand appears to regulate EphA2 subcellular localization and its interactions with downstream adapter and signaling proteins. Eph receptor A2(EphA2) has been demonstrated to critically regulate tumor cell growth, migration and invasiveness. Eph receptor A2(EphA2) is frequently overexpressed and functionally altered in aggressive tumor cells, and that these changes promote metastatic character.

参考文献

1. Flanagan JG, et al. (1998) The ephrins and Eph receptors in neural development. Annu Rev Neurosci. 21: 309-45. 2. Cheng N, et al. (2002) The ephrins and Eph receptors in angiogenesis. Cytokine Growth Factor Rev. 13(1): 75-85. 3. Pratt RL, et al. (2002) Activation of the EphA2 tyrosine kinase stimulates the MAP/ERK kinase signaling cascade. Oncogene. 21(50): 7690-9. 4. Jennifer Walker-Daniels, et al. (2003) Differential Regulation of EphA2 in Normal and Malignant Cells. Am J Pathol. 162(4): 1037-1042.

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Keywords

EphA2 Protein, Human, Recombinant (aa 585-976, His & GST) ARCC-2 CTPP 1 ARCC2 EPH receptor A2 ARCC 2 CTPA CTRCT 6 ECK CTPP1 CTRCT-6 CTRCT6 CTPP-1 recombinant recombinant-proteins proteins protein

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