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Pheneturide (Benuride) 是Phenobarbita l 脱羧后的产物，可阻止精神运动性癫痫发作。

MRS4608是一种新型的P2Y14受体强效拮抗剂。

MRS4654 是一种新型的高效 P2Y14 受体拮抗剂，具有15 nM 的半最大抑制浓度 (IC50)。

GTS467 is a EAAT2 Activator.

LY-364947 (HTS466284) 是有效的、ATP 竞争性的TGFβR-I 抑制剂(IC50:59 nM)，是对 TGFβR-II 选择性的 7 倍。

WR-S-462 是一种STAT3抑制剂，在体外能有效地阻碍STAT3的磷酸化及其生物学功能。该化合物对MDA-MB-231细胞的IC50为0.03 μM，并表现出对STAT3蛋白的强结合亲和力，其Kd为58 nM。WR-S-462 能抑制p-STAT3的核转位，特异性抑制MDA-MB-231细胞中p-STAT3Tyr705的表达，以及由STAT3调控的下游靶基因如Cyclin D1、Bcl-2和Bcl-xl的表达。此外，WR-S-462 有效抑制三阴性乳腺癌 (TNBC) 的生长和转移。

Doripenem 是对革兰氏阳性菌、阴性菌和厌氧菌有效的β-内酰胺广谱抗生素。

TCS 46b 是一种具有口服活性的 NR1A NR2B NMDA 受体拮抗剂。

BMS-466442 is the first selective amino acid transporter alanine serine cysteine transporter-1 inhibitor.

GS-462808 is a late sodium current inhibitor of the cardiac Nav1.5 channel. GS-462808 had lower brain penetration and serendipitously lower activity at the brain isoforms.

CS 461 is a cephalosporin antibiotic that has shown effective antimicrobial activity against a variety of bacteria in vitro and in vivo.

PXS-4681A is a powerful, specific, and irreversible inhibitor of semicarbazide-sensitive amine oxidase (SSAO; VAP-1), with an oral activity and a Ki value of 37 nM. It exhibits exceptional selectivity towards related amine oxidases, ion channels, and seven-transmembrane domain receptors. Additionally, PXS-4681A demonstrates potent anti-inflammatory properties.

Chaetomellic acid A is a potent inhibitor of farnesyltransferase in isolated enzyme assays (IC50=55nM) but is inactive in whole cells. Inhibition of farnesyltransferase is selective over geranylgeranyltransferase I and II (IC50=92µM and 34µM respectively).

NPS-467 is a specific CaR agonist.

HRS-4642 为针对 KRAS(G12D) 的选择性抑制剂，解离常数 (Kd) 为 0.083 nM，显示出抗癌活性。此化合物与 Carfilzomib 协同作用，显著提升体内效力，并能转变肿瘤微环境为免疫激活状态。