natriuretic peptide

Sacubitril (AHU-377) 是一种有效的NEP 抑制剂，IC50=5 nM。它是研究心力衰竭药物 LCZ696 的组分之一。

Mouse Brain Natriuretic Peptide-45 (BNP-45, mouse) is a circulating variant of the mouse brain natriuretic peptide derived from the mouse heart. It exhibits powerful hypotensive and natriuretic properties.

Brain Natriuretic Peptide-45, rat TFA (BNP-45, rat TFA) 为来源于大鼠心脏的脑利钠肽循环同源物，具有显著的降压和利尿效果。

BNP-45 (rat) is a circulating form of rat brain natriuretic peptide isolated from rat heart with potent hypotensive and natriuretic potency.

NPRA agonist-11 (Example 161) 是一种NPRA (NPR1)激动剂，对人类和猴子的AC50值分别为1.681 μM和0.989 μM。NPRA agonist-11 可用于研究心血管相关疾病。

C-Type Natriuretic Peptide (CNP) (1-22), human acetate 是一种利钠肽受体 B (NPR-B) 的激动剂，一种内皮衍生的松弛剂和生长抑制因子。 C-Type Natriuretic Peptide (CNP) (1-22), human acetate 抑制由组胺和 5-HT 或直接由毛喉素刺激的 cAMP 合成。

Brain Natriuretic Peptide (1-32), rat acetate (BNP (1-32), rat acetate) is a 32 amino acid polypeptide hormone synthesized by ventricular cardiomyocytes as a result of myocardial cell stretching (cardiomyocyte distension)[1].

Atrial Natriuretic Peptide (1-28), human, porcine, Biotin-labeled, is one of three mammalian natriuretic peptides (NPs) that exerts endocrine effects on fluid homeostasis and blood pressure. Atrial Natriuretic Peptide holds promise for cardiovascular diseases research.

C-Type Natriuretic Peptide (CNP) (1-22), human (TFA), is a 22 amino acid fragment of CNP and functions as an agonist for the natriuretic peptide receptor B (NPR-B). It can inhibit cAMP synthesis, which is induced by histamine, 5-HT, or Forskolin. Additionally, CNP exhibits strong endothelial-derived relaxation properties and acts as a growth inhibitor.

Atrial natriuretic peptide (3-28) (human) 是由心房心肌细胞合成并分泌的肽类激素，主要在调节血压、体液平衡及电解质稳态方面发挥作用。

Dendroaspis Natriuretic Peptide为源于动物毒液的血管舒张肽类化合物。

BNP-32（Brain natriuretic peptide-32）是心血管激素前体proBNP的肽段，能够结合大鼠血管平滑肌上的利钠肽受体（IC50 = 7.3 nM），并在同样的细胞中促进cGMP积累（EC50 = 170 nM）。BNP-32还能使经去甲肾上腺素预收缩的孤立大鼠主动脉条带松弛（EC50 = 6.7 nM），当以3 µg/kg的剂量给药时，能增加大鼠的尿量和尿液电解质排泄，并诱导低血压。

Atrial Natriuretic Peptide (1-28), rat is the major circulating form of ANP in rats.

CNP, a member of the natriuretic peptide family, was first identified in porcine brain and later found in other mammals as well as non-mammals. Processing of the CNP precursor gives rise to CNP-22 and its N-terminally elongated form, CNP-53. The CNPs shar

Brain Natriuretic Peptide (BNP) (1-32), rat is a 32 amino acid polypeptide secreted by the ventricles of the heart in response to excessive stretching of heart muscle cells (cardiomyocytes).Brain natriuretic peptide (type B natriuretic peptide) was origin

C-Type Natriuretic Peptide (1-53), Porcine, Rat, mouse 主要作为颗粒鸟苷酸环化酶 B (pGC-B) 的激活剂，广泛存在于内皮细胞、肾脏和心脏中。该化合物在心脏和肾脏的成纤维细胞中通过产生二级信使cGMP发挥显著的抗纤维化功能。

C-Type Natriuretic Peptide (CNP) (1-22), human 是一种利钠肽受体 B (NPR-B) 激动剂，是一种 CNP 的 1-22 片段。它对生理激动剂组胺和 5-HT 刺激或直接由 Forskolin 刺激的 cAMP 合成具有抑制作用。其中CNP 是一种有效的、内皮衍生的松弛剂和生长抑制因子。

Atrial Natriuretic Peptide (ANP) (1-28), human, porcine Acetate是一种由心房肌细胞分泌的钠尿肽（ANP）激素，能够作为NPR-A激动剂并用于治疗急性失代偿性心力衰竭 (ADHF)。通过与肾脏、血管和心脏细胞表面的特定受体结合，Carperitide（卡培立肽）导致环磷酸鸟苷 (cGMP)水平的升高并引起血管扩张，利尿和排钠，从而通过降低心脏的工作负荷。

Nesiritide is the recombinant form of the 32 amino acid human B-type natriuretic peptide, which is normally produced by the ventricular myocardium. It is an agonist of natriuretic peptide receptors (NPRs), with Kd values of 7.3 and 13 pM for NPR-A and NPR

AP 811, a selective antagonist of the atrial natriuretic peptide clearance receptor (APN-CR, NPR3) with a K i value of 0.48 nM, exhibits remarkable selectivity for NPR3 over NPR1 by more than 20,000-fold. Moreover, AP 811 effectively eliminates ANP-induced pump stimulation.

Urodilatin为ANF-(99-126)的同类物，属于利尿钠调节肽。该化合物主要应用于急性肾功能衰竭、充血性心力衰竭、支气管哮喘等疾病的研究领域。

BNP (1-21), Pro (Human) 是一种由21个氨基酸组成的心脏激素多肽。作为B型利钠肽(BNP)的一部分，与心房利钠肽高度同源，共同构成了心脏的双利钠肽系统。BNP 主要参与心脏发生的调节，并涉及向子宫外环境过渡的生理进程。

Atriopeptin III (ANP 127-150) (rat)是包含24个氨基酸的心房肽，作用为有效的血管舒张剂及利尿剂。在输尿管梗阻大鼠模型中，Atriopeptin III (rat)能够改善肾功能并降低血压，同时适用于慢性肾功能衰竭研究。

Nesiritide, a 32-amino acid natriuretic peptide and recombinant form of human brain natriuretic peptide, enhances vasorelaxation ex vivo in porcine hearts from an acute coronary occlusion model when given as a 2 µg/kg bolus dose followed by a 0.01 µg/kg per minute infusion, facilitated by the calcium ionophore A23187. Formulations containing nesiritide have been utilized in managing congestive heart failure.