mitochondrial membrane depolarization

DD1 (HUN85111) 是一种蛋白酶体抑制剂，可诱导人髓系肿瘤选择性凋亡。

Genistein 8-c-glucoside (G8CG) 诱导线粒体膜去极化从而导致细胞凋亡。Genistein 8-c-glucoside 是一种来源于 Lupinus luteus L.花中的天然葡萄糖苷。

p38-α MAPK-IN-8 (Compound 13) 是一种亲脂性阳离子衍生物，具有细胞毒性，对多种肿瘤细胞有效。它能够诱导细胞周期阻滞和凋亡 (apoptosis)，增加活性氧 (ROS) 生成，同时诱导线粒体膜电位去极化。其抗肿瘤活性可能与p38αMAPK途径有关，可用于肿瘤研究。

Mitochondria modulator-2 (Compound Ir1) 诱导线粒体膜电位去极化，诱导ROS生成，抑制A549细胞迁移，阻滞G2 M期的细胞周期，并诱导A549细胞凋亡 (apoptosis)。

EGFR-IN-141 (Compound 8I) 是一种EGFR抑制剂，其IC50为2.67 nM。在癌细胞A549中，EGFR-IN-141显示出细胞毒性，IC50为13.75 μM。该化合物可以诱导细胞凋亡 (apoptosis) 和线粒体膜去极化，并且表现出潜在的抗肿瘤活性。

Sitamaquine is an antileishmanial agent.1It is active againstL. donovani,L. infantum,L. mexicana,L. braziliensis, andL. tropica(EC50s = 9.5-19.8 μM). It inhibits mitochondrial complex II, also known as succinate dehydrogenase (SDH), in a cell-free assay when used at concentrations ranging from 10 to 200 μM.2Sitamaquine (100 μM) increases intracellular levels of reactive oxygen species (ROS) and decreases intracellular ATP levels, as well as induces phosphatidylserine externalization, chromatin fragmentation, and depolarization of the mitochondrial membrane potential, markers of apoptosis, inL. donovanipromastigotes. 1.López-Martín, C., Pérez-Victoria, J.M., Carvalho, L., et al.Sitamaquine sensitivity in Leishmania species is not mediated by drug accumulation in acidocalcisomesAntimicrob. Agents Chemother.52(11)4030-4036(2008) 2.Carvalho, L.J.M., Luque-Ortega, J.R., López-Martín, C., et al.The 8-aminoquinoline analogue sitamaquine causes oxidative stress in Leishmania donovani promastigotes by targeting succinate dehydrogenaseAntimicrob. Agents Chemother.55(9)4204-4210(2011)

BMAP 28, bovine 是一种抗菌肽，能通过增强细胞膜通透性引发细胞内容物泄漏，对革兰氏阳性菌和革兰氏阴性菌展现抗菌活性。BMAP 28, bovine 对癌细胞及活化的人类淋巴细胞具有细胞毒性，并通过线粒体膜电位去极化诱导细胞凋亡 (apoptosis)。