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Targets Recommended: Complement System

44

抑制剂 & 化合物

9

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28

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Cat. No. Product Name Target Signaling Pathways
T9189 Iptacopan hydrochloride

Iptacopan HCl,LNP023 hydrochloride

Complement System Immunology/Inflammation
Iptacopan hydrochloride (LNP023 hydrochloride) 是一种可口服、高效和高选择性的因子 B 抑制剂,IC50 为 10 nM。 LNP023 显示与人因子 B 的直接、可逆和高亲和力结合,KD 为 7.9 nM。
T13041 Surfactin

HSV Microbiology/Virology
Surfactin 是一种有效的环状脂肽生物表面活性剂,可介导单价和二价阳离子(如钙)穿过脂质双层膜的通量,具有抗菌、抗真菌、抗支原体和溶血作用。
T76867 Ravulizumab

ALXN1210

Complement System Immunology/Inflammation
Ravulizumab (ALXN1210) 是一种靶向补体因子 5 的人源化单克隆抗体,它以高亲和力特异性结合人补体蛋白 C5,可阻断补体激活。Ravulizumab 可用于预防和治疗阵发性睡眠性血红蛋白尿症、非典型溶血性尿毒症综合征和重症肌无力。
T1386 Phenazopyridine hydrochloride

Urodine,Pyridium,Phenazopyridine HCl,盐酸非那吡啶

Sodium Channel Membrane transporter/Ion channel
Phenazopyridine hydrochloride (Pyridium) 是一种具有局部止痛作用的化学物质,常被用于缓解手术、损伤尿道及尿路感染引起的疼痛、刺激、不适和尿急。
TP1018L Urechistachykinin II acetate

Urechistachykinin II acetate(149097-04-1 free base),Uru-TK II acetate

Others Others
Urechistachykinin II acetate (Uru-TK II acetate)(149097-04-1 free base) 是一种从类胡萝卜素蠕虫中分离出来的无脊椎动物快速激肽相关肽 (TRPs),显示出抗菌活性而没有溶血作用。
T8509 Danicopan

ACH-4471

Complement System Immunology/Inflammation
Danicopan (ACH-4471) 是一种可口服的小分子 D 因子选择性抑制剂,对人 D 因子具有高结合亲和力,Kd 值为 0.54 nM。 它可抑制补体替代途径 (APC) 的活性,具有阻断阵发性夜间血红蛋白尿 (PNH) 和非典型溶血性尿毒症综合征 (aHUS) 的补体替代途径的潜力。
T25702 Levovirin

ICN 17261,L-Ribavirin,ICN-17261,ICN17261

Levovirin is a monocyclic L-nucleosides with type 1 cytokine-inducing activity. Levovirin is the L-enantiomer of Ribavirin. Levovirin has similar immunomodulatory activity but does not have direct antiviral activity or hemolytic anemia.
T80398 Brevinin-1PMa

Brevinin-1PMa为宿主防御肽,对金黄色葡萄球菌(Staphylococcus aureus)和大肠杆菌(Escherichia coli)展现出抗菌活性,并具溶血活性。
T16992 Taribavirin hydrochloride

Others Others
Taribavirin hydrochloride is an orally active inosine monophosphate dehydrogenase inhibitor. Taribavirin hydrochloride is designed to concentrate within the liver to target HCV-infected hepatocytes while minimizing distribution within red blood cells and
T38259 Phenelfamycin E

Phenelfamycin E is an antibiotic originally isolated from Streptomyces. It is active against β-hemolytic Streptoccus, S. pneumoniae, C. difficile, C. perfringens, and P. magnus128 μg/ml). Phenelfamycin E (4-64 mg/kg) increases survival in a mouse model of lethal S. pyogenes infection in a dose-dependent manner. Dietary administration of phenelfamycin E increases body weight in chickens.
T81514 Peptide 5f

Peptide 5f 是一种源自大黄蜂毒液的抗菌肽,对细菌和真菌展现出显著的抗菌活性,同时对人类血红细胞的溶血活性极低。
T80373 Maximin 77

Maximin 77为抗菌肽,针对S. aureus表现出抗菌活性(MIC: 18.8 μg/mL),且对人红细胞具有溶血性。
T80370 Maximin 42

Maximin 42为一抗菌肽,针对S. aureus表现出抗菌活性(MIC: 37.5 μg/mL),同时对人红细胞具溶血活性。
T80366 Maximin 49

Maximin 49为一种具备针对S. aureus抗菌能力的抗菌肽(MIC: 18.8 μg/mL),且对人类与兔子的红细胞表现出溶血性。
T76570 PSM-β

PSM-β 是一种活性肽,可从表皮葡萄球菌中分离得到。PSM-β 是葡萄球菌毒素的类似物,也是一种酚溶性调节蛋白。PSM-β 具有抑菌和低溶血性。
T63552 FtsZ-IN-1

FtsZ-IN-1 是有效的、具有喹啉环的 FtsZ 抑制剂,对革兰氏阳性菌具有较强的抑菌效果 (MIC: 0.5-8 μg/mL)。FtsZ-IN-1 能够提高 FtsZ 聚合作用,明显促进枯草芽孢杆菌 (B. subtilis) 的细胞伸长。FtsZ-IN-1 拥有低溶血毒性和低诱导耐药倾向,表现出抗耐药性细菌效果。
T80139 CRAMP-18 (mouse)

Antibiotic Microbiology/Virology
CRAMP-18 (mouse)为一种抗生素肽,具备抗革兰氏阴性菌能力而不具溶血活性,能有效抑制包括S. typhimurium和P. aeruginosa在内的菌株。此外,CRAMP-18 (mouse)展现了抗真菌、抗细菌及抗肿瘤的研究潜力。
T80364 Maximin 45

Maximin 45为一种具备抗菌特性的肽类化合物,针对S. aureus、E. coli、B. subtilis展现出了抗菌活性(MIC分别为4.7、9.4、75 μg/mL),同时,Maximin 45对人类和兔子红细胞显示出溶血活性。
T71266 Omadacycline HCl

Omadacycline, also known as PTK 0796 and Amadacyclin, is a novel first-in-class aminomethylcycline with potent activity against important skin and pneumonia pathogens, including community-acquired methicillin-resistant Staphylococcus aureus (MRSA), β-hemolytic streptococci, penicillin-resistant Streptococcus pneumoniae, Haemophilus influenzae, and Legionella. Omadacycline is active against strains expressing the two main forms of tetracycline resistance (efflux and ribosomal protection). The pri...
T80368 Im5

Im5 是一种具有针对 Escherichia coli、Staphylococcus aureus、Bacillus subtilis 的抗菌活性(MIC:10、2.5-5、0.5-1 μM)的抗菌肽,同时表现出溶血性(EC50: 28 μM)。
T16993 Taribavirin

Others Others
Taribavirin is an orally active inosine monophosphate dehydrogenase inhibitor. Taribavirin is designed to concentrate within the liver to target HCV-infected hepatocytes while minimizing distribution within red blood cells (RBCs) and the development of he
T80363 Maximin 41

Maximin 41是一种具有针对S. aureus抗菌活性(MIC: 75 μg/mL)的抗菌肽,同时对人红细胞展现溶血活性。
T80394 Des(8-14)brevinin-1PMa

Des(8-14)brevinin-1PMa是一种具有抗金黄色葡萄球菌和大肠杆菌活性的宿主防御肽,同时也表现出溶血性。
T79468 Antimicrobial agent-22

Antimicrobial agent-22 (THI 6c)是一种具有低细胞毒性、溶血性和快速杀菌能力的多靶点广谱抗菌剂,且展现出良好的抗生物膜活性。
T78914 S-F24

S-F24是一种抗真菌剂,显示出优异的广谱性(fungal)。该化合物在抑制CYP3A4方面的IC50为0.4 μM,表现出良好的安全性和高选择性,同时具有低溶血活性及较低的诱导耐药性。S-F24适用于真菌感染研究。
T76468 Cecropin A (1-7)-Melittin A (2-9)

Cecropin A (1-7)-Melittin A (2-9) 是一种抗菌肽,对广谱革兰氏阳性和革兰氏阴性需氧菌具有一定的抗菌活性,与此同时也具有一定的抗疟活性,且没有蜂毒肽的不良溶血特性。
T74527 Anti-MRSA agent 4

Anti-MRSA agent 4 (compound 7a) 是革兰氏阳性耐甲氧西林金黄色葡萄球菌 (MRSA)的强效选择性生长抑制剂,MIC≤ 0.26 µM。Anti-MRSA agent 4 在 HEK293 细胞中未表现出细胞毒性和溶血活性。
T78935 Quorum Sensing-IN-2

Quorum Sensing-IN-2(compound 23e)是一款不影响细菌生长的群体感应抑制剂,具有减少细菌致病性的功能。该化合物在抑制细菌感染方面表现出效力,同时具有极低的溶血活性。在铜绿假单胞菌PAO1引起的菌血症模型中,Quorum Sensing-IN-2与环丙沙星共同作用,显示了协同效应。
T80365 Maximin H39

Maximin H39为一种抗菌肽,对C. albicans、S. aureus、B. subtilis展示抗菌活性(MIC: 9.4, 9.4, 18.8 μg/mL),且对人类及兔子红细胞具溶血活性。
T75582 Naja Melanoleuca Venom

Naja Melanoleuca Venom (Forest Cobra Venom) 是一种蛇毒,可从 Naja Melanoleuca 获得。Naja Melanoleuca Venom 对人类红细胞具有溶血活性。α-神经毒素可以从 Naja Melanoleuca 毒液中分离出来,并抑制 GABAA 受体功能。
T80369 Maximin 68

Maximin 68为抗菌肽,其对C. albicans、S. aureus、E. coli、B. subtilis显示出抗菌活性(MIC分别为18.8、9.4、37.5、9.4 μg/mL),并对人和兔红细胞表现出溶血活性。
T74788 FtsZ-IN-5

FtsZ-IN-5 是一种有效的FtsZ 抑制剂,可促进 FtsZ 聚合并抑制 FtsZ 的 GTPase 活性。因此,FtsZ-IN-5 抑制细菌分裂导致细菌细胞死亡。FtsZ-IN-5 显示出杀菌活性,没有明显的引发细菌耐药性的趋势以及快速杀菌特性。并且 FtsZ-IN-5 对哺乳动物细胞表现出低溶血活性和细胞毒性。
T74553 YSK 05

YSK 05 是一种 pH 敏感的阳离子脂质。YSK 05 可改善非病毒载体的胞内转运。YSK 05-MEND 表现出明显良好的基因沉默活性和溶血活性。YSK 05 通过聚乙二醇化克服了对内体逃逸的抑制。YSK 05 在体外和体内均有效增强 siRNA 传递。
T80378 Tilapia piscidin 3

Tilapia piscidin 3 是具抗菌谱广的肽类化合物,有效对抗多种革兰氏阳性菌与阴性菌,其对 V. vulnificus 204、V. alginolyticus、S. agalactiae 819、E. faecalis BCRC 10066、S. agalactiae BCRC 10787 的最小抑菌浓度 (MIC) 分别为 2.44、2.44、9.78、19.55、0.61 μg/mL。同時,Tilapia piscidin 3 对鱼红细胞显示出溶血性。
T80367 Maximin 78

Maximin 78为一种具有广谱抗菌性能的肽类化合物。该化合物展现出针对C. albicans、S. aureus、B. subtilis的显著抗菌活性,最小抑菌浓度(MIC)分别为37.5、4.7、37.5 μg/mL。此外,Maximin 78对人类和兔子红细胞显示出溶血活性。
T80286 TP4 (Nile tilapia piscidin)

Necroptosis Apoptosis
TP4(Nile tilapia piscidin)是一种piscidin样的抗菌肽,其口服活性被证实。此化合物对多种革兰氏阳性及阴性菌株均有效(MIC: 0.03-10 μg/mL),并展现了溶血性。TP4还能增强免疫响应、提升抗氧化能力和改善肠道健康,助于防御细菌感染。除此之外,TP4显示抗肿瘤效果,并可通过激发癌细胞线粒体功能障碍导致坏死(necrosis)。
T82474 Empasiprubart

ARGX-117

Empasiprubart (ARGX-117) 是一种针对补体 C2 的人源化抑制性单克隆抗体。该抗体通过结合 C2 的 Sushi-2 结构域来阻止 C3 原转化酶的形成,进而抑制 C3 的激活,并阻断经典途径与凝集素途径的上游激活。Empasiprubart 展现出 pH 和钙依赖性的靶标结合能力,并在自身免疫性溶血性贫血以及抗体介导的器官移植排斥模型中,预防了补体介导的细胞毒性作用。
T73127 C16-K-cBB1

C16-K-cBB1 是一种对 MRSA(甲氧西林耐药金黄色葡萄球菌)有效且选择性的抗菌剂,其 MIC 为 1 μg/mL。C16-K-cBB1 具有很好的选择性,由于其溶血活性较弱。在 12.5 μg/mL 浓度下,C16-K-cBB1 能够在 120 分钟内杀死 MRSA 细胞。
T80262 SMAP-18

SMAP-18是一种具有高生物活性的18氨基酸残基肽酰胺,为SMAP-29 (羊髓系抗菌肽-29) 的缩短版本。SMAP-29对假单胞菌菌株、其他革兰氏阴性菌及多重耐药病原体有很强的抗菌作用。SMAP-18相较于母体SMAP-29,表现出更高的细胞选择性,因其降低了溶血活性同时保留了抗菌能力。
T74791 FtsZ-IN-8

FtsZ-IN-8 是一种有效的FtsZ 抑制剂,可促进 FtsZ 聚合并抑制 FtsZ 的 GTPase 活性。因此,FtsZ-IN-8 抑制细菌分裂导致细菌细胞死亡。FtsZ-IN-8 显示出杀菌活性,没有明显的引发细菌耐药性的趋势以及快速杀菌特性。并且 FtsZ-IN-8 对哺乳动物细胞表现出低溶血活性和细胞毒性。
T74789 FtsZ-IN-6

FtsZ-IN-6 是一种有效的FtsZ 抑制剂,可促进 FtsZ 聚合并抑制 FtsZ 的 GTPase 活性。因此,FtsZ-IN-6 抑制细菌分裂导致细菌细胞死亡。FtsZ-IN-6 显示出杀菌活性,没有明显的引发细菌耐药性的趋势以及快速杀菌特性。并且 FtsZ-IN-6 对哺乳动物细胞表现出低溶血活性和细胞毒性。
T74790 FtsZ-IN-7

FtsZ-IN-7 是一种有效的FtsZ 抑制剂,可促进 FtsZ 聚合并抑制 FtsZ 的 GTPase 活性。因此,FtsZ-IN-7 抑制细菌分裂导致细菌细胞死亡。FtsZ-IN-7 显示出杀菌活性,没有明显的引发细菌耐药性的趋势以及快速杀菌特性。并且 FtsZ-IN-7 对哺乳动物细胞表现出低溶血活性和细胞毒性。
T80252 BMAP-18

BMAP-18为一抗菌肽,是Cathelicidin肽家族中的成员,为BMAP-27的截短版,具备针对Staphylococcus aureus、Streptococcus uberis和Escherichia coli的快速杀菌作用。相比其亲本BMAP-27,BMAP-18展现出优越的细胞选择性,降低了对人红细胞和中性粒细胞的溶血作用,同时保留其抗菌能力。
T37873 CAP 3

CAP 3 is a cholic acid-peptide conjugate (CAP) with antibacterial activity. It is active against the Gram-negative bacteria E. coli, K. pneumoniae, and A. baumanii (MIC99s = 8, 16, and 16 μM, respectively). CAP 3 increases the fluidity of model Gram-negative bacterial membranes and binds to LPS in vitro. It reduces the biomass and number of colony-forming units in E. coli biofilms in a concentration-dependent manner. CAP 3 inhibits E. coli biofilm formation on catheters implanted in mice infecte...

化合物

Iptacopan hydrochloride
Cat.No: T9189
Synonym: Iptacopan HCl,LNP023 hydrochloride
Target: Complement System
Surfactin
Cat.No: T13041
Synonym:
Target: HSV
Ravulizumab
Cat.No: T76867
Synonym: ALXN1210
Target: Complement System
Phenazopyridine hydrochloride
Cat.No: T1386
Synonym: Urodine,Pyridium,Phenazopyridine HCl,盐酸非那吡啶
Target: Sodium Channel
Urechistachykinin II acetate
Cat.No: TP1018L
Synonym: Urechistachykinin II acetate(149097-04-1 free base),Uru-TK II acetate
Target: Others
Danicopan
Cat.No: T8509
Synonym: ACH-4471
Target: Complement System
Levovirin
Cat.No: T25702
Synonym: ICN 17261,L-Ribavirin,ICN-17261,ICN17261
Target:
Brevinin-1PMa
Cat.No: T80398
Synonym:
Target:
Taribavirin hydrochloride
Cat.No: T16992
Synonym:
Target: Others
Phenelfamycin E
Cat.No: T38259
Synonym:
Target:
Peptide 5f
Cat.No: T81514
Synonym:
Target:
Maximin 77
Cat.No: T80373
Synonym:
Target:
Maximin 42
Cat.No: T80370
Synonym:
Target:
Maximin 49
Cat.No: T80366
Synonym:
Target:
PSM-β
Cat.No: T76570
Synonym:
Target:
FtsZ-IN-1
Cat.No: T63552
Synonym:
Target:
CRAMP-18 (mouse)
Cat.No: T80139
Synonym:
Target: Antibiotic
Maximin 45
Cat.No: T80364
Synonym:
Target:
Omadacycline HCl
Cat.No: T71266
Synonym:
Target:
Im5
Cat.No: T80368
Synonym:
Target:
Taribavirin
Cat.No: T16993
Synonym:
Target: Others
Maximin 41
Cat.No: T80363
Synonym:
Target:
Des(8-14)brevinin-1PMa
Cat.No: T80394
Synonym:
Target:
Antimicrobial agent-22
Cat.No: T79468
Synonym:
Target:
S-F24
Cat.No: T78914
Synonym:
Target:
Cecropin A (1-7)-Melittin A (2-9)
Cat.No: T76468
Synonym:
Target:
Anti-MRSA agent 4
Cat.No: T74527
Synonym:
Target:
Quorum Sensing-IN-2
Cat.No: T78935
Synonym:
Target:
Maximin H39
Cat.No: T80365
Synonym:
Target:
Naja Melanoleuca Venom
Cat.No: T75582
Synonym:
Target:
Maximin 68
Cat.No: T80369
Synonym:
Target:
FtsZ-IN-5
Cat.No: T74788
Synonym:
Target:
YSK 05
Cat.No: T74553
Synonym:
Target:
Tilapia piscidin 3
Cat.No: T80378
Synonym:
Target:
Maximin 78
Cat.No: T80367
Synonym:
Target:
TP4 (Nile tilapia piscidin)
Cat.No: T80286
Synonym:
Target: Necroptosis
Empasiprubart
Cat.No: T82474
Synonym: ARGX-117
Target:
C16-K-cBB1
Cat.No: T73127
Synonym:
Target:
SMAP-18
Cat.No: T80262
Synonym:
Target:
FtsZ-IN-8
Cat.No: T74791
Synonym:
Target:
FtsZ-IN-6
Cat.No: T74789
Synonym:
Target:
FtsZ-IN-7
Cat.No: T74790
Synonym:
Target:
BMAP-18
Cat.No: T80252
Synonym:
Target:
CAP 3
Cat.No: T37873
Synonym:
Target:
Cat. No. Product Name Target Signaling Pathways
TN6864 Prosaikogenin F

(2R,3R,4S,5R,6R)-2-{[(1S,2R,4S,5R,8R,9S,10R,13S,14R,17S,18R)-2-hydroxy-9-(hydroxymethyl)-4,5,9,13,20,20-hexamethyl-24-oxahexacyclo[15.5.2.01,1?.0?,1?.0?,1?.0?,13]tetracos-15-en-10-yl]oxy}-6-methyloxane-3,4,5-triol,前柴胡皂苷F

Others Others
Prosaikogenin F ((2R,3R,4S,5R,6R)-2-{[(1S,2R,4S,5R,8R,9S,10R,13S,14R,17S,18R)-2-hydroxy-9-(hydroxymethyl)-4,5,9,13,20,20-hexamethyl-24-oxahexacyclo[15.5.2.01,1?.0?,1?.0?,1?.0?,13]tetracos-15-en-10-yl]oxy}-6-methyloxane-3,4,5-triol) 是一种单糖苷,具有溶血和抗癌特性。
TN2088 Platycodin D2

桔梗皂苷D2

IL Receptor; HBV Immunology/Inflammation; Microbiology/Virology
Platycodin D2 是分离自桔梗的皂苷类物质,显示除抗癌活性。
T3368 Alpha-Hederin

α常春藤皂甙,Helixin,Tauroside E,α-Hederin,Hederoside C

Apoptosis; Others Apoptosis; Others
Alpha-Hederin (Tauroside E) 是存在于黑种草种子中的一种单桥糖三萜皂苷,具有抗肿瘤作用。它可通过激活线粒体依赖性途径抑制胃癌细胞增殖,诱导凋亡,并有活性氧生成和谷胱甘肽减少。
T3891 Oroxylin A-7-O-glucuronide

Oroxylin A Glucoronide,千层纸素A-7-0-Β-D-葡萄糖醛酸苷,Oroxyloside,Oroxylin A 7-O-beta-D-glucuronide

Others Others
Oroxylin A-7-O-glucuronide (Oroxylin A Glucoronide) 是一种类黄酮葡糖苷酸,提取自 Scutellaria baicalensis 干燥的根中,具有脯氨酰寡肽酶(POP)抑制作用。
T41138 Prosaikogenin H

Prosaikogenin H is an intestinal metabolite of saikosaponin with a weak hemolytic activity.
TN4804 Platycoside A

Antifection Microbiology/Virology
Platycoside A has hemolytic activity and adjuvant potential on the immune responses to Newcastle disease virus-based recombinant avian influenza vaccine. It induces the IgG and IgG1 antibody responses in the immunized mice.
TN5930 Ocotillone

Ocotillone has potent antibacterial activity against Gram-negative bacteria, P. aeruginosa and S. typhimurium, that are without hemolytic activity, whereas it has weak antimicrobial activity against Gram-positive bacteria and fungi. Ocotillone shows only
T76129 Hemocyanin

Hemocyanin 是一种大的含铜呼吸蛋白。Hemocyanin 是一种重要的非特异性先天免疫防御分子,具有酚氧化酶、抗病毒、抗菌、溶血和抗肿瘤活性。
T36439 Gramicidin A

Antibacterial; HIF; Parasite Angiogenesis; Chromatin/Epigenetic; Microbiology/Virology
Gramicidin A 是一种从从 B. brevis 分离出来的多肽类抗生素。Gramicidin A 是一种高度疏水的通道形成离子载体,在人工膜中形成一价阳离子可渗透的通道。Gramicidin A 诱导缺氧诱导因子 1α (HIF-1α) 的降解,并能降低人肾细胞癌小鼠异种移植模型的生长。Gramicidin A 具有抗菌、抗疟活性以及溶血活性。

天然产物

Prosaikogenin F
Cat.No: TN6864
Synonym: (2R,3R,4S,5R,6R)-2-{[(1S,2R,4S,5R,8R,9S,10R,13S,14R,17S,18R)-2-hydroxy-9-(hydroxymethyl)-4,5,9,13,20,20-hexamethyl-24-oxahexacyclo[15.5.2.01,1?.0?,1?.0?,1?.0?,13]tetracos-15-en-10-yl]oxy}-6-methyloxane-3,4,5-triol,前柴胡皂苷F
Target: Others
Platycodin D2
Cat.No: TN2088
Synonym: 桔梗皂苷D2
Target: IL Receptor, HBV
Alpha-Hederin
Cat.No: T3368
Synonym: α常春藤皂甙,Helixin,Tauroside E,α-Hederin,Hederoside C
Target: Apoptosis, Others
Oroxylin A-7-O-glucuronide
Cat.No: T3891
Synonym: Oroxylin A Glucoronide,千层纸素A-7-0-Β-D-葡萄糖醛酸苷,Oroxyloside,Oroxylin A 7-O-beta-D-glucuronide
Target: Others
Prosaikogenin H
Cat.No: T41138
Synonym:
Target:
Platycoside A
Cat.No: TN4804
Synonym:
Target: Antifection
Ocotillone
Cat.No: TN5930
Synonym:
Target:
Hemocyanin
Cat.No: T76129
Synonym:
Target:
Gramicidin A
Cat.No: T36439
Synonym:
Target: Antibacterial, HIF, Parasite
Cat. No. Product Name Species Expression System
TMPY-01075 Von Willebrand Factor/vWF Protein, Human, Recombinant (His)

von Willebrand factor,VWD,F8VWF

Human CHO
Von Willebrand Factor (VWF) is a multimeric glycoprotein involved in hemostasis in blood, binds receptors on the surface of platelets and in connective tissue, thereby mediating the adhesion of platelets to sites of vascular injury. From studies it appears that VWF protein uncoils under these circumstances, decelerating passing platelets. VWF protein is deficient or defective in von Willebrand disease (VWD) and is involved in a large number of other diseases, including thrombosis, thrombotic thr...
TMPH-03557 HlgC Protein, S. aureus, Recombinant (His)

Staphylococcus aureus Yeast
Toxin that seems to act by forming pores in the membrane of the cell. Has a hemolytic and a leucotoxic activity.
TMPH-03556 HlgC Protein, S. aureus, Recombinant (E. coli, His)

Staphylococcus aureus E. coli
Toxin that seems to act by forming pores in the membrane of the cell. Has a hemolytic and a leucotoxic activity.
TMPH-00582 Endopeptidase Clp Protein, E. coli, Recombinant (His & Myc)

E. coli E. coli
Toxin, which has some hemolytic activity towards mammalian cells. Acts by forming a pore-like structure upon contact with mammalian cells.
TMPH-00474 Der p 6 Protein, Dermatophagoides pteronyssinus, Recombinant (GST)

Dermatophagoides pteronyssinus E. coli
Pore-forming toxin that specifically binds sphingomyelin in the plasma membrane of various cells. Has hemolytic activity. It also has antibacterial activities against B.megaterium.
TMPH-03554 HlgB Protein, S. aureus, Recombinant (E. coli, His)

Staphylococcus aureus E. coli
Toxin that seems to act by forming pores in the membrane of the cell. Has a hemolytic and a leucotoxic activity.
TMPH-03206 ITGB8 Protein, Rabbit, Recombinant (His & Myc)

Rabbit E. coli
Toxin that seems to act by forming pores in the membrane of the cell. Has a hemolytic and a leucotoxic activity.
TMPY-04765 PKLR Protein, Human, Recombinant (His)

PKRL,PKR,RPK,PKL,PK1,pyruvate kinase, liver and RBC

Human E. coli
Pyruvate kinase (PKLR) is a critical erythrocyte enzyme that is required for glycolysis and production of ATP. Pyruvate kinase deficiency (PKD) is the most frequent red blood cell enzyme abnormality of the glycolytic pathway and the most common cause of hereditary nonspherocytic hemolytic anemia. Over 250 PKLR-gene mutations have been described, including missense/nonsense, splicing and regulatory mutations, small insertions, small and gross deletions, causing PKD and hemolytic anemia of variabl...
TMPH-03209 CLNS1A Protein, Rabbit, Recombinant (His & Myc)

Rabbit E. coli
Toxin that seems to act by forming pores in the membrane of the cell. Has a hemolytic and a leucotoxic activity.
TMPH-03205 HINT1 Protein, Rabbit, Recombinant (His & Myc)

Rabbit HEK293
Toxin that seems to act by forming pores in the membrane of the cell. Has a hemolytic and a leucotoxic activity.
TMPH-03208 IL-6 Protein, Rabbit, Recombinant (His)

Rabbit Yeast
Toxin that seems to act by forming pores in the membrane of the cell. Has a hemolytic and a leucotoxic activity.
TMPH-03207 IL-2 Protein, Rabbit, Recombinant (His)

Rabbit E. coli
Toxin that seems to act by forming pores in the membrane of the cell. Has a hemolytic and a leucotoxic activity.
TMPH-03555 HlgB Protein, S. aureus, Recombinant (His)

Staphylococcus aureus Yeast
Toxin that seems to act by forming pores in the membrane of the cell. Has a hemolytic and a leucotoxic activity.
TMPH-03553 HlgA Protein, S. aureus, Recombinant (His & Myc)

Staphylococcus aureus E. coli
Toxin that seems to act by forming pores in the membrane of the cell. Has a hemolytic and a leucotoxic activity.
TMPJ-01034 TIM Protein, Human, Recombinant (His)

TPI1,TPI,Triose-Phosphate Isomerase,Triosephosphate Isomeras...

Human E. coli
Triose-phosphate isomerase, also named Triose-phosphate isomerase, TPI and TIM, is an enzyme that catalyzes the reversible interconversion of the triose phosphate isomers dihydroxyacetone phosphate and D-glyceraldehyde 3-phosphate. TPI has been found in nearly every organism searched for the enzyme, including animals such as mammals and insects as well as in fungi, plants, and bacteria. However, some bacteria that do not perform glycolysis, like ureaplasmas, lack TPI. TPI plays an important role...
TMPJ-01306 CFHR5 Protein, Human, Recombinant (His)

Complement factor H-related protein 5,CFHR5,FHR5,CFHL5

Human Human Cells
Complement factor H-related protein 5(FHR-5 for short), is a secreted protein which contains 9 Sushi (CCP/SCR) domains. It is expressed by the liver and secreted in plasma. The pattern of the deposits is similar to other complement components, suggesting that FHR-5 may play a role in complement activation and regulation. Defects in CFHR5 have been found in patients with atypical hemolytic uremic syndrome and may contribute to the disease. In contrast to typical hemolytic uremic syndrome, atypica...
TMPH-02728 ITM2A Protein, Mouse, Recombinant (His)

Mouse in vitro E. coli expression system
Heterodimer protein that may serve both defensive (pain-inducing) and predatory (insecticidal) roles. Has membrane-disrupting activity and shows induction of non-specific calcium influx into cells,. Shows broad-spectrum activity against a diverse range of bacteria, and cell lines, as well as hemolytic activity (EC(50)=2.18 uM). In vivo, shows moderate insecticidal activity against D.melanogaster and potent anthelmintic activity against the veterinary nematode H.contortus. In addition, intraplant...
TMPY-02023 CD46 Protein, Human, Recombinant (His)

AHUS2,MIC10,CD46 molecule, complement regulatory protein,TLX...

Human HEK293
CD46, also known as Membrane Cofactor Protein (MCP), is a complement regulatory protein. CD46 is a type 1 membrane protein that plays an important inhibitory role in the complement system. CD46 is expressed in white blood cells, platelets, epithelial cells, and fibroblasts. Human CD46 shares 5% amino acid sequence identity with mouse and rat CD46. The importance of CD46 to complement regulation is underscored by the observation that genetic loss of CD46 leads to development of atypical hemolytic...
TMPH-02174 PYCR1 Protein, Human, Recombinant (His & SUMO)

Human E. coli
Cysteine proteinase with a strong preference for substrates with Lys in the P1 position. Hydrolyzes bovine hemoglobin, bovine serum albumin, casein, human placental type I collagen and human IgA and IgG. Disrupts the functions of polymorphonuclear leukocytes. May act as a virulence factor in the development of peridontal disease. Involved in the coaggregation of P.gingivalis with other oral bacteria. Has hemolytic activity; this is mediated by the adhesin domains and does not require the catalyt...
TMPJ-00800 BPGM Protein, Human, Recombinant (His)

3-Diphosphoglycerate Mutase,2,DPGM,Bisphosphoglycerate Mutas...

Human E. coli
Bisphosphoglycerate Mutase (BPGM) is a member of the Phosphoglycerate Mutase family and BPG-Dependent PGAM subfamily. BPGM is a multifunctional enzyme. BPGM catalyzes 2,3-DPG synthesis via its synthetase activity, and 2,3-DPG degradation via its phosphatase activity. It also has phosphoglycerate phosphomutase activity. BPGM plays a major role in regulating hemoglobin oxygen affinity by controlling the levels of 2,3-bisphosphoglycerate (2,3-BPG). Deficiency of BPGM increases the affinity of cells...
TMPY-03271 Thrombomodulin Protein, Rat, Recombinant (His)

thrombomodulin

Rat HEK293
Thrombomodulin, also known as THBD (CD141), is an integral membrane protein that reduces blood coagulation by converting thrombin to an anticoagulant enzyme from a procoagulant enzyme. Thrombomodulin is expressed on the surface of endothelial cells and serves as a cofactor for thrombin. It is also expressed on human mesothelial cell, monocyte and a dendritic cell subset. Thrombomodulin functions as a cofactor in the thrombin-induced activation of protein C in the anticoagulant pathway by forming...
TMPJ-00836 G6PD Protein, Human, Recombinant (His)

Glucose-6-Phosphate 1-Dehydrogenase,G6PD

Human Human Cells
Glucose-6-Phosphate 1-Dehydrogenase (G6PD) is a cytosolic enzyme that belongs to the glucose-6-phosphate dehydrogenase family. G6PD participates in the pentose phosphate pathway that supplies reducing energy to cells by maintaining the level of the co-enzyme nicotinamide adenine dinucleotide phosphate (NADPH). G6PD produces pentose sugars for nucleic acid synthesis and main producer of NADPH reducing power. NADPH in turn maintains the level of glutathione in these cells that helps protect the re...
TMPY-05829 Thrombomodulin Protein, Human, Recombinant (His)

thrombomodulin,THPH12,CD141,TM,AHUS6,BDCA3,THRM

Human HEK293
Thrombomodulin, also known as THBD (CD141), is an integral membrane protein that reduces blood coagulation by converting thrombin to an anticoagulant enzyme from a procoagulant enzyme. Thrombomodulin is expressed on the surface of endothelial cells and serves as a cofactor for thrombin. It is also expressed on human mesothelial cell, monocyte and a dendritic cell subset. Thrombomodulin functions as a cofactor in the thrombin-induced activation of protein C in the anticoagulant pathway by forming...
TMPH-00473 Der p 3 Protein, Dermatophagoides pteronyssinus, Recombinant (His)

Dermatophagoides pteronyssinus E. coli
Pore-forming toxin that defensively acts against parasitic microorganisms by forming pores in sphingomyelin-containing membranes. Has hemolytic activity and is also cytotoxic to spermatozoa of some species of invertebrates and many species of vertebrates and to amphibian larvae, guinea pig polymorphonuclear leukocytes, chicken fibroblasts, normal spleen cells and various tumor cells. Is lethal for various species of reptiles, amphibian, birds and mammals. Induces smooth muscle contraction. It bi...
TMPY-02835 DEFB103A Protein, Human, Recombinant (His)

DEFB3,HBP3,defensin, beta 103A,hBD-3,DEFB103,DEFB-3,HBD3,HBP...

Human E. coli
Beta-defensin 3 is a member of the defensin family. Defensin family is comprised by microbicidal and cytotoxic peptides made by neutrophils. Members of the beta-defensin 3 family are highly similar in protein sequence. Beta-defensin 3 shows antimicrobial activity against Gram-positive bacteria S.aureus and S.pyogenes, Gram-negative bacteria P.aeruginosa and E.coli and the yeast C.albicans. Beta-defensin 3 is abundantly expressed in skin and tonsils, and to a lesser extent in trachea, uterus, kid...
TMPJ-00979 GSH-S Protein, Human, Recombinant (His)

Glutathione Synthetase,GSS,GSH-S,GSH Synthetase,Glutathione ...

Human E. coli
Glutathione Synthetase belongs to the eukaryotic GSH synthase family. Glutathione Synthetase is the second enzyme in the glutathione biosynthesis pathway. It catalyses the condensation of gamma-glutamylcysteine and glycine to form glutathione. Glutathione play an important role in a variety of biological functions, including detoxification of xenobiotics, protection of cells from oxidative damage by free radicals, and membrane transport. The protein functions as a homodimer to catalyze the secon...
TMPY-04141 Complement factor H/CFH Protein, Mouse, Recombinant (hFc)

complement factor H,Sas1,NOM,Mud-1,Sas-1

Mouse HEK293
Complement factor H, also known as H factor 1, and CFH, is a sialic acid containing glycoprotein that plays an integral role in the regulation of the complement-mediated immune system that is involved in microbial defense, immune complex processing, and programmed cell death. Factor H protects host cells from injury resulting from unrestrained complement activation. CFH regulates complement activation on self cells by possessing both cofactor activity for the Factor I mediated C3b cleavage, and ...
TMPY-04129 Complement factor H/CFH Protein, Mouse, Recombinant (His)

Sas-1,Mud-1,NOM,complement factor H,Sas1

Mouse HEK293
Complement factor H, also known as H factor 1, and CFH, is a sialic acid containing glycoprotein that plays an integral role in the regulation of the complement-mediated immune system that is involved in microbial defense, immune complex processing, and programmed cell death. Factor H protects host cells from injury resulting from unrestrained complement activation. CFH regulates complement activation on self cells by possessing both cofactor activity for the Factor I mediated C3b cleavage, and ...

重组蛋白

Von Willebrand Factor/vWF Protein, Human, Recombinant (His)
Cat.No: TMPY-01075
Species: Human
Expression System: CHO
HlgC Protein, S. aureus, Recombinant (His)
Cat.No: TMPH-03557
Species: Staphylococcus aureus
Expression System: Yeast
HlgC Protein, S. aureus, Recombinant (E. coli, His)
Cat.No: TMPH-03556
Species: Staphylococcus aureus
Expression System: E. coli
Endopeptidase Clp Protein, E. coli, Recombinant (His & Myc)
Cat.No: TMPH-00582
Species: E. coli
Expression System: E. coli
Der p 6 Protein, Dermatophagoides pteronyssinus, Recombinant (GST)
Cat.No: TMPH-00474
Species: Dermatophagoides pteronyssinus
Expression System: E. coli
HlgB Protein, S. aureus, Recombinant (E. coli, His)
Cat.No: TMPH-03554
Species: Staphylococcus aureus
Expression System: E. coli
ITGB8 Protein, Rabbit, Recombinant (His & Myc)
Cat.No: TMPH-03206
Species: Rabbit
Expression System: E. coli
PKLR Protein, Human, Recombinant (His)
Cat.No: TMPY-04765
Species: Human
Expression System: E. coli
CLNS1A Protein, Rabbit, Recombinant (His & Myc)
Cat.No: TMPH-03209
Species: Rabbit
Expression System: E. coli
HINT1 Protein, Rabbit, Recombinant (His & Myc)
Cat.No: TMPH-03205
Species: Rabbit
Expression System: HEK293
IL-6 Protein, Rabbit, Recombinant (His)
Cat.No: TMPH-03208
Species: Rabbit
Expression System: Yeast
IL-2 Protein, Rabbit, Recombinant (His)
Cat.No: TMPH-03207
Species: Rabbit
Expression System: E. coli
HlgB Protein, S. aureus, Recombinant (His)
Cat.No: TMPH-03555
Species: Staphylococcus aureus
Expression System: Yeast
HlgA Protein, S. aureus, Recombinant (His & Myc)
Cat.No: TMPH-03553
Species: Staphylococcus aureus
Expression System: E. coli
TIM Protein, Human, Recombinant (His)
Cat.No: TMPJ-01034
Species: Human
Expression System: E. coli
CFHR5 Protein, Human, Recombinant (His)
Cat.No: TMPJ-01306
Species: Human
Expression System: Human Cells
ITM2A Protein, Mouse, Recombinant (His)
Cat.No: TMPH-02728
Species: Mouse
Expression System: in vitro E. coli expression system
CD46 Protein, Human, Recombinant (His)
Cat.No: TMPY-02023
Species: Human
Expression System: HEK293
PYCR1 Protein, Human, Recombinant (His & SUMO)
Cat.No: TMPH-02174
Species: Human
Expression System: E. coli
BPGM Protein, Human, Recombinant (His)
Cat.No: TMPJ-00800
Species: Human
Expression System: E. coli
Thrombomodulin Protein, Rat, Recombinant (His)
Cat.No: TMPY-03271
Species: Rat
Expression System: HEK293
G6PD Protein, Human, Recombinant (His)
Cat.No: TMPJ-00836
Species: Human
Expression System: Human Cells
Thrombomodulin Protein, Human, Recombinant (His)
Cat.No: TMPY-05829
Species: Human
Expression System: HEK293
Der p 3 Protein, Dermatophagoides pteronyssinus, Recombinant (His)
Cat.No: TMPH-00473
Species: Dermatophagoides pteronyssinus
Expression System: E. coli
DEFB103A Protein, Human, Recombinant (His)
Cat.No: TMPY-02835
Species: Human
Expression System: E. coli
GSH-S Protein, Human, Recombinant (His)
Cat.No: TMPJ-00979
Species: Human
Expression System: E. coli
Complement factor H/CFH Protein, Mouse, Recombinant (hFc)
Cat.No: TMPY-04141
Species: Mouse
Expression System: HEK293
Complement factor H/CFH Protein, Mouse, Recombinant (His)
Cat.No: TMPY-04129
Species: Mouse
Expression System: HEK293
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