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Questiomycin A derivatives 18 TFA 是一种Questiomycin A 衍生物，Questiomycin A 具有抗菌和抗癌活性 ，对细胞保护性 ER 伴侣蛋白 GRP78 的表达具有抑制作用。

Questiomycin A derivatives 12 是一种Questiomycin A 衍生物。

Questiomycin A derivatives 14 是一种 Questiomycin A 衍生物。

Questiomycin A derivatives 13 是一种 Questiomycin A 衍生物。

VHL Ligand-Linker Conjugates 17 are chemical compounds that consist of a VHL ligand specialized for the E3 ubiquitin ligase, as well as a PROTAC linker. These conjugates are utilized in the synthesis of various PROTACs, including the notable ARD-266. ARD-266 is an exceptionally effective androgen receptor (AR) PROTAC degrader[1].

AhR Ligand-Linker Conjugates 1, also known as E3 Ligase Ligand-Linker Conjugates 57, is a chemical compound that combines an IAP ligand for the E3 ubiquitin ligase with a SNIPER linker. It is specifically designed to be used in the development of SNIPER[1].

cIAP1 Ligand-Linker Conjugates 16 refers to a specific type of ligase ligand-linker conjugate, possessing the ability to engage with E3 ligases, which finds application in the synthesis of PROTACs.

cIAP1 Ligand-Linker Conjugates 11 Hydrochloride is a chemical compound consisting of an IAP ligand that targets the E3 ubiquitin ligase, along with a PROTAC linker. It is primarily utilized in the development of SNIPERs, a molecular tool for targeted protein degradation[1].

cIAP1 Ligand-Linker Conjugates 15 hydrochloride is a chemical compound that combines an IAP ligand for the E3 ubiquitin ligase and a PROTAC linker. This compound is useful in the development of SNIPERs[1].

cIAP1 Ligand-Linker Conjugates 1 is composed of an IAP ligand for the E3 ubiquitin ligase and a PROTAC linker. This compound, cIAP1 Ligand-Linker Conjugates 1, is particularly useful in the development of SNIPERs[1].

Rivulariapeptolides 1155 是一种有效的丝氨酸蛋白酶 (serine protease) 抑制剂，对糜蛋白酶、弹性蛋白酶、蛋白蛋白酶 K 的 IC50分别为 41.84、4.94、56.54 nM。

cIAP1 Ligand-Linker Conjugates 14 consist of an IAP ligand that targets the E3 ubiquitin ligase and a PROTAC linker. These conjugates, known as cIAP1 Ligand-Linker Conjugates 14, are used in the development of SNIPERs[1].

cIAP1 Ligand-Linker Conjugates 11 is a chemical compound that combines an IAP ligand specifically designed for the E3 ubiquitin ligase with a PROTAC linker. This compound, cIAP1 Ligand-Linker Conjugates 11, is useful in the development of SNIPERs[1], allowing for the targeted degradation of proteins.

ERRα Ligand-Linker Conjugates 1 refers to a chemical compound that consists of a ligand targeting estrogen-related receptor alpha (ERRα), and a PROTAC linker that facilitates the recruitment of E3 ligases MDM2. It finds utility in the synthesis of a range of PROTACs, including one known as PROTAC ERRalpha Degrader-1. With its capability to induce degradation of ERRα, PROTAC ERRalpha Degrader-1 functions as an ERRα degrader[1].

cIAP1 Ligand-Linker Conjugates 12 is a chemical compound that combines an IAP ligand, which targets the E3 ubiquitin ligase, with a PROTAC linker. This compound, cIAP1 Ligand-Linker Conjugates 12, is valuable for creating SNIPERs[1].

cIAP1 Ligand-Linker Conjugates 13, containing an IAP ligand for the E3 ubiquitin ligase, and a PROTAC linker, are utilized in the development of SNIPERs[1].

cIAP1 Ligand-Linker Conjugates 15 consists of an IAP ligand that targets the E3 ubiquitin ligase, along with a PROTAC linker. This compound, cIAP1 Ligand-Linker Conjugates 15, is suitable for the development of SNIPERs[1].

cIAP1 Ligand-Linker Conjugates 10 comprise of an IAP ligand and a PROTAC linker, which facilitates the design of SNIPERs. These conjugates incorporate an IAP ligand that interacts with the E3 ubiquitin ligase, and a PROTAC linker. SNIPERs can be developed using cIAP1 Ligand-Linker Conjugates 10.

VHL Ligand-Linker Conjugates 15 is a chemical compound that combines a VHL ligand, which targets the E3 ubiquitin ligase, with a PROTAC linker. It is specifically designed for the creation of PROTACs[1].

CCK2R Ligand-Linker Conjugate 1 is a hydrophilic peptide linker that conjugates to the cytotoxic antimicrotubule agents Desacetyl Vinblastine Hydrazide (DAVBH) and Tubulysin B Hydrazide (TubBH) as ligand-linker conjugates[1].

TSPO Ligand-Linker Conjugates 1，包含TSPO配体和连接子，用于合成靶向线粒体的AUTAC。该AUTAC能与OMM上TSPO结合，通过mitophagy降解受损线粒体和蛋白质，提升线粒体活性。适用于研究线粒体功能紊乱，包括神经退行性疾病、癌症和糖尿病。

Rivulariapeptolides 1121，作为一种高效的选择性丝氨酸蛋白酶抑制剂，对胰凝蛋白酶、弹性蛋白酶和蛋白酶K展示出了显著的抑制活性，其IC50值分别为35.52 nM、13.24 nM和48.05 nM。

Rivulariapeptolides 1185 是一种高效的选择性丝氨酸蛋白酶抑制剂，其对胰凝蛋白酶、弹性蛋白酶和蛋白酶 K 的 IC50分别为 13.17 nM、23.59 nM 和 55.26 nM。

Cisplatin (CDDP) 是一种 DNA 交联剂。Cisplatin 具有抗肿瘤活性，能够通过在癌细胞中形成 DNA 加合物来抑制 DNA 合成。Cisplatin 还可激活铁死亡并诱导自噬。