Name: Daxdilimab
Brand: TargetMol
SKU: T76767
Price: 1650 CNY
Availability: InStock
Rating: 5 (10 reviews)

规格

价格

库存

数量

1 mg

¥ 1,650

现货

5 mg

¥ 4,280

现货

10 mg

¥ 6,870

现货

25 mg

¥ 12,700

现货

50 mg

¥ 19,800

现货

生物活性

产品描述	Daxdilimab is a fully human monoclonal antibody targeting ILT7 (LILRA4), which is specifically expressed on plasmacytoid dendritic cells (pDCs). Daxdilimab depletes pDCs in circulation and tissues by inducing ADCC. As pDCs are the primary source of Type 1 interferons (IFN-I), this antibody effectively reduces IFN-I production and suppresses interferon-inducible gene signatures, serving as a tool for researching autoimmune diseases like SLE, dermatomyositis, and Sjögren's syndrome.
体外活性	在生化实验中，Daxdilimab 结合人 pDCs 表面的 ILT7。功能实验显示，该抗体诱导 PBMCs 中 ADCC 介导的 pDCs 清除，导致 TLR 激动剂刺激后的 IFN-alpha 分泌显著减少 [1][2]。
体内活性	在人源化小鼠或非人灵长类模型中，系统给予 Daxdilimab (1-10 mg/kg) 导致血液和皮肤组织中 pDCs 快速且持续清除，并显著下调干扰素刺激基因 (ISGs) 的表达 [2]。
别名	达司迪利单抗, VIB7734, MEDI7734
反应种属	Human
应用	ELISA FACS Functional assay
抗体种类	Monoclonal
缓冲液	Supplied as a sterile solution in a buffered formulation system (e.g., phosphate-, citrate-, or amino acid-based). Please refer to the CoA for lot-specific composition.
内毒素	<1.0 EU/mg

抗体信息

同型

IgG1-REM

偶联与修饰

偶联	Unconjugated

抗原信息

Uniprot ID	P59901
靶点	IL-T7

化学信息

CAS No.

2245966-28-1

储存&溶解度

存储	Store at -20°C Shipping with blue ice/Shipping at ambient temperature. 实际储存温度请以COA为准

Daxdilimab