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32

抑制剂 & 化合物

9

天然产物

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Cat. No.	Product Name	Target	Signaling Pathways
T12937	SMS1-IN-1	Others	Others
	SMS1-IN-1 是一种有效的鞘磷脂合成酶1 (SMS1, IC50 = 2.1 μM) 抑制剂，可用于动脉粥样硬化研究。
T21508	Anhydrotetracycline hydrochloride	Antibacterial; Antibiotic	Microbiology/Virology
	Anhydrotetracycline hydrochloride 是四环素的生物合成前体，是广谱的、有效的竞争性四环素破坏酶抑制剂。它是真核细胞中四环素控制的基因表达系统的效应子。
T7092	NADPH tetrasodium salt	Others; Ferroptosis; Endogenous Metabolite	Apoptosis; Metabolism; Others
	NADPH tetrasodium salt 是电子受体烟酰胺腺嘌呤二核苷酸磷酸的还原形式，在各种生物反应中充当电子供体。NADPH tetrasodium salt 也是一种内源性铁死亡抑制剂。
T8934	(6R)-FR054 (3AR,7AR)-5-(乙酰氧基甲基)-2-甲基-5,6,7,7A-四氢-3AH-吡喃并[3,2-D]噁唑-6,7-叉基二醋酸盐,FR054	Apoptosis; Others	Apoptosis; Others
	(6R)-FR054 是己糖胺生物合成途径酶 PGM3 的抑制剂，具有显著的抗乳腺癌作用。
T19596	UDP-GlcNAc Disodium Salt Uridine 5′-diphospho-N-acetylglucosamine,5′-二磷酸尿嘧啶核苷-N-乙酰半乳糖胺二钠盐,UDP-α-D-N-Acetylglucosamine Disodium Salt	Others	Others
	UDP-GlcNAc Disodium Salt (UDP-α-D-N-Acetylglucosamine Disodium Salt) 是一种 O-GlcNAc 转移酶 (OGT) 的供体底物。
T11019	DHODH-IN-1	Dehydrogenase	Metabolism
	DHODH-IN-1 是一种有效的 DHODH 抑制剂 (IC50 = 25 nM) 并抑制嘧啶生物合成途径。
T9468	FR054	Others	Others
	FR054 是一种己糖胺生物合成途径酶 PGM3 的抑制剂，具有明显的抗乳腺癌活性。它在不同的乳腺癌细胞中诱导细胞增殖和存活显著降低。
T37185	D-(-)-3-Phosphoglyceric acid disodium 3-Phospho-D-glyceric acid disodium	Others	Others
	D-(-)-3-Phosphoglyceric acid disodium (3-Phospho-D-glyceric acid disodium) 是糖酵解、糖原合成以及丝氨酸、甘氨酸、苏氨酸生物合成等过程中的重要中间体,竞争性抑制酵母烯醇化酶 (enolase)。作为中间体它还在植物、真核细胞以及原核细胞许多的生物合成信号通路中发挥许多作用。
T14884	CBR-5884	Others; Dehydrogenase	Metabolism; Others
	CBR-5884 是一种磷酸甘油酸脱氢酶抑制剂，IC50为 33 μM。它抑制癌细胞中的丝氨酸合成，选择性地抑制黑素瘤和乳腺癌细胞系的增殖，对具有高丝氨酸生物合成活性的癌细胞系有选择性毒性。
T24904	TSI-01 TSI 01
	TSI-01 is a selective PAF biosynthetic enzyme lysophosphatidylcholine acyltransferase 2 inhibitor.
T16712	(R)-Pantetheine Pantetheine	Others	Others
	(R)-Pantetheine is the biosynthetic precursor to CoA. (R)-Pantetheine and its corresponding disulfide pantethine play a key role in metabolism .
T14882	CB30865 ZM 242421	Others	Others
	CB30865 is a potent inhibitor of Nampt, an enzyme present in the NAD biosynthetic pathway.
T68218	S 8660
	S 8660 is an analogue of brequinar sodium that inhibits the pyrimidine biosynthetic pathway.
T71865	DSM43
	DSM43 is a dihydroorotate dehydrogenase (DHODH) inhibitor. Malaria puts at risk nearly half the world's population and causes high mortality in sub-Saharan Africa, while drug resistance threatens current therapies. The pyrimidine biosynthetic enzyme dihydroorotate dehydrogenase (DHODH) is a validated target for malaria treatmen
T40184	Cannabigerolic acid
	Cannabigerolic acid (CBGA), a dihydroxybenzoic acid, serves as a biosynthetic precursor for Tetrahydrocannabinolic acid (THCA). It is characterized by its ability to exhibit cyclooxygenase (COX) inhibitory effects.
T40178	6,7-Dimethyl-8-ribityllumazine
	6,7-Dimethyl-8-ribityllumazine is a biosynthetic precursor of Riboflavin (RBF). It serves as a noncovalently bound fluorophore of Lumazine protein (LumP), an accessory protein that exhibits fluorescence.
T36365	KAPA (hydrochloride) KAPA (hydrochloride),7-keto-8-Aminopelargomic Acid
	Biotin is a growth factor that plays an important role in numerous reactions that are critical to microorganisms, plants, and animals. Biotin has a strong affinity for the protein avidin, a trait that has been utilized for many assay reporter applications. KAPA is a key intermediate in the biotin biosynthetic pathway.[1]
T80982	TIS108
	TIS108为一种抑制三唑型独脚金内酯生物合成的化合物。它抑制拟南芥的胚胎发生并降低水稻中2′-epi-5-deoxystrigol (epi-5DS)的含量。
T37617	Leukotriene B3
	LTB3 is the LTA hydrolase metabolite of LTA3 in the leukotriene biosynthetic pathway. LTB3 and LTB4 are equipotent in their pro-inflammatory effects. However, LTB3 is five times less potent than LTB4 in eliciting chemotaxis of human neutrophils.
T38085	Neoantimycin
	Neoantimycin is an antibiotic originally isolated from S. orinoci that has slight antifungal activity. It is structurally similar to antimycin despite being produced by an unrelated species of Streptomyces. The biosynthetic pathway of neoantimycin has been determined and active analogs discovered.
T74986	MRV03-070
	MRV03-070，作为大肠杆菌素激活肽酶ClbP的抑制剂，展现出与生物合成前体前肌动蛋白相似的作用机制，其IC50值为69 nM。
T69623	Tridemorph
	Tridemorph is a sterol biosynthetic inhibitor. It is a fungicide used to control Erysiphe graminis. It was developed by BASF in the 1960s who use the trade name Calixin. The World Health Organization has categorized it as a Class II moderately hazardous" pesticide because it is believed harmful if swallowed and can cause irritation to skin and eyes."
T37789	Riboflavin 5'-monophosphate (sodium salt hydrate)
	Riboflavin 5'-monophosphate (FMN) is a coenzyme that is tightly bound to enzymes catalyzing oxidation and reduction reactions in a variety of biosynthetic pathways. FMN also binds the FMN riboswitch (RFN element) on RNA to alter gene regulation. FMN is a substrate of FMN phosphohydrolases and is used to study their function.
T63779	RmlA-IN-2
	RmlA-IN-2 是 1-磷酸葡萄糖胸苷转移酶 (RmlA) 的有效抑制剂 (IC50: 0.303 μM)。RmlA-IN-2 能够影响单糖 l-鼠李糖生物合成途径，并影响细菌细胞壁通透性。
T60833	Mycobactin-IN-2
	Mycobactin-IN-2 (化合物 49) 是与水杨酰-AMP 连接酶 (MbtA) 结合的分枝杆菌素生物合成抑制剂，MbtA 是分枝杆菌素生物合成途径的关键酶。
T77789	Oleoyl-L-alpha-lysophosphatidic acid sodium salt LPA sodium salt
	Oleoyl-L-alpha-lysophosphatidic acid sodium salt为必需的细胞膜生物合成代谢物，可通过与G蛋白偶联受体（GPCR）（即LPA受体）相互作用来介导信号传导，是LPA1和LPA2受体的内源性激动剂。
T60486	Mycobactin-IN-1
	Mycobactin-IN-1 (compound 44) 是一种吡唑啉类似物。Mycobactin-IN-1 与分支菌素生物合成途径中的关键酶，水杨酸-AMP 连接酶 (MbtA) 结合。Mycobactin-IN-1 是分支菌素生物合成的抑制剂，具有抗分枝杆菌的作用。
T36740	Guanosine 5’-diphosphate (sodium salt hydrate)
	Guanosine 5’-diphosphate (GDP) is a purine nucleotide and biosynthetic precursor of guanosine 5’-triphosphate .1It has been used to study the conformations of GTPases.2GDP (100 μM) activates sulfonylurea receptor 2B (SUR2B) linked to the inward-rectifier potassium channel 6.1 (Kir6.1) in HEK293T cells in a patch-clamp assay.3 1.Berg, J.M., Tymoczko, J.L., and Stryer, L.Biochemistry(2002) 2.Vetter, I.R., and Wittinghofer, A.The guanine nucleotide-binding switch in three dimensionsScience294(5545)...
T40753	Cytidine-5'-triphosphate Cytidine triphosphate,Cytidine-5'-triphosphate,5'-CTP
	Cytidine 5'-triphosphate (5'-CTP), also known as cytidine triphosphate, is a nucleoside triphosphate that plays a crucial role as a building block for nucleotides and nucleic acids, as well as lipid biosynthesis. It is synthesized through the catalytic action of cytidine triphosphate synthase, which converts uridine 5'-triphosphate (UTP) to cytidine 5'-triphosphate. Cytidine 5'-triphosphate is an essential biomolecule in T. gondii's de novo pyrimidine biosynthetic pathway.
T35428	β-Rubromycin
	β-Rubromycin is a bacterial metabolite originally isolated from Streptomyces that has diverse biological activities.1 It inhibits the growth of HMO2, KATO-III, and MCF-7 cells with GI50 values of 0.5, 0.84, and <0.1 μM, respectively. β-rubromycin inhibits HIV-1 reverse transcriptase activity by 39.7% when used at a concentration of 10 μM. It also has antibacterial activity against Gram-positive bacteria. The structure of β-rubromycin was originally described as containing an ortho-quinone group,...
T35979	Benastatin C
	Benastatin C is a polyketide synthase-derived benastatin that has been found inStreptomycesand has diverse biological activities.1,2It inhibits glutathione S-transferase (GST; IC50= 24 μg/ml for the rat liver enzyme).2Benastatin C also inhibits the esterase activity of isolated porcine pancreatic lipase (IC50= 10 μg/ml). It increases LPS- or concanavalin A-induced blastogenesis of isolated mouse spleen lymphocytes in a concentration-dependent manner. 1.Xu, Z., Schenk, A., and Hertweck, C.Molecul...
T35978	Benastatin A
	Benastatin A is a polyketide synthase-derived benastatin that has been found inStreptomycesand has diverse biological activities.1,2,3It inhibits glutathione S-transferase (GST; Ki= 5 μM for the rat liver enzyme).2Benastatin A is active against several bacteria, including methicillin-resistantS. aureus(MRSA; MIC = 3.12 μg/ml). It induces apoptosis and cell cycle arrest at the G1/G0phase in Colon 26 mouse colon cancer cells when used at concentrations of 20 and 16 μM, respectively.3 1.Xu, Z., Sch...

化合物

Cat.No: T12937

Target: Others

Anhydrotetracycline hydrochloride

Cat.No: T21508

Target: Antibacterial, Antibiotic

NADPH tetrasodium salt

Cat.No: T7092

Target: Others, Ferroptosis, Endogenous Metabolite

Cat.No: T8934

Synonym: (3AR,7AR)-5-(乙酰氧基甲基)-2-甲基-5,6,7,7A-四氢-3AH-吡喃并[3,2-D]噁唑-6,7-叉基二醋酸盐,FR054

Target: Apoptosis, Others

UDP-GlcNAc Disodium Salt

Cat.No: T19596

Synonym: Uridine 5′-diphospho-N-acetylglucosamine,5′-二磷酸尿嘧啶核苷-N-乙酰半乳糖胺二钠盐,UDP-α-D-N-Acetylglucosamine Disodium Salt

Target: Others

Cat.No: T11019

Target: Dehydrogenase

Cat.No: T9468

Target: Others

D-(-)-3-Phosphoglyceric acid disodium

Cat.No: T37185

Synonym: 3-Phospho-D-glyceric acid disodium

Target: Others

Cat.No: T14884

Target: Others, Dehydrogenase

Cat.No: T24904

Synonym: TSI 01

(R)-Pantetheine

Cat.No: T16712

Synonym: Pantetheine

Target: Others

Cat.No: T14882

Synonym: ZM 242421

Target: Others

Cat.No: T68218

Cat.No: T71865

Cannabigerolic acid

Cat.No: T40184

6,7-Dimethyl-8-ribityllumazine

Cat.No: T40178

KAPA (hydrochloride)

Cat.No: T36365

Synonym: KAPA (hydrochloride),7-keto-8-Aminopelargomic Acid

Cat.No: T80982

Cat.No: T37617

Cat.No: T38085

Cat.No: T74986

Cat.No: T69623

Riboflavin 5'-monophosphate (sodium salt hydrate)

Cat.No: T37789

Cat.No: T63779

Mycobactin-IN-2

Cat.No: T60833

Oleoyl-L-alpha-lysophosphatidic acid sodium salt

Cat.No: T77789

Synonym: LPA sodium salt

Mycobactin-IN-1

Cat.No: T60486

Guanosine 5’-diphosphate (sodium salt hydrate)

Cat.No: T36740

Cytidine-5'-triphosphate

Cat.No: T40753

Synonym: Cytidine triphosphate,Cytidine-5'-triphosphate,5'-CTP

Cat.No: T35428

Cat.No: T35979

Cat.No: T35978

Cat. No.	Product Name	Target	Signaling Pathways
T2O2776	L-Valine	Others; Endogenous Metabolite	Metabolism; Others
	L-Valine 是蛋白二十种氨基酸中的其中一种。它是必需氨基酸。
T4439	sn-Glycero-3-phosphocholine Choline Alfoscerate,甘磷酸胆碱,Glycerophosphocholine,Glycerophosphorylcholine,Alpha-GPC,Choline glycerophosphate,L-α-GPC	Endogenous Metabolite; AChE	Metabolism; Neuroscience
	sn-Glycero-3-phosphocholine (Choline glycerophosphate) 是脑磷脂生物合成的前体，能够提高胆碱在神经组织中的生物利用度。它对认知功能有显著影响，同时具有良好的耐受性和安全性，因此能够用于阿尔茨海默病和痴呆症的研究。
T19599	Uridine diphosphate glucose	Others	Others
	Uridine diphosphate glucose is an important intermediate in several different metabolic pathways and biosynthetic reactions.
T31520	Diplopterol
	Diplopterol is biosynthetic of squalene for use in acetobacter pasteurii in a cell-free system. It is a hopanoid and can be used as a substitute for sterols.
TN4889	(R)-Reticuline	NADPH-oxidase	Immunology/Inflammation
	(R)-Reticuline is the biosynthetic precursor of the morphinan alkaloids.
T19268	D-Sedoheptulose 7-phosphate	Others	Others
	D-Sedoheptulose 7-phosphate is a common precursor of heptaic acid (group III) and hygromycin B (group IV) heptasaccharide. D-heptadecane 7-phosphate can be converted to NDP-heptose by similar biosynthetic pathways in these compounds.
TN4488	Mallorepine	Others	Others
	Mallorepine may propably be an intermediate on the biosynthetic pathway from nicotinamide (II) to ricinine (III).
T32800	Littorine (R)-(-)-Littorine
	Littorine is a tropane alkaloid found in a variety of plants including Datura and Atropa belladonna. It is closely related in chemical structure to atropine, hyoscyamine, and scopolamine, which all share a common biosynthetic pathway.
TN5235	Vinorine	Others	Others
	Vinorine is a direct biosynthetic precursor along the complex pathway to the monoterpenoid indole alkaloid ajmaline, an antiarrhythmic drug from the Indian medicinal plant Rauvolfia serpentina.

天然产物

Cat.No: T2O2776

Target: Others, Endogenous Metabolite

sn-Glycero-3-phosphocholine

Cat.No: T4439

Synonym: Choline Alfoscerate,甘磷酸胆碱,Glycerophosphocholine,Glycerophosphorylcholine,Alpha-GPC,Choline glycerophosphate,L-α-GPC

Target: Endogenous Metabolite, AChE

Uridine diphosphate glucose

Cat.No: T19599

Target: Others

Cat.No: T31520

Cat.No: TN4889

Target: NADPH-oxidase

D-Sedoheptulose 7-phosphate

Cat.No: T19268

Target: Others

Cat.No: TN4488

Target: Others

Cat.No: T32800

Synonym: (R)-(-)-Littorine

Cat.No: TN5235

Target: Others

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