bdnf (human)

Member of the neurotrophin growth factor family that binds and activates TrkB and p75 neurotrophin receptors. Enhances the survival, growth and differentiation of neurons. BDNF expression is altered in neurodegenerative disorders such as Parkinson's and A

Nurr1 agonist 12 (Compound 37) 是一种激活核受体相关蛋白 1 (Nurr1) 的激动剂，能增强 Nurr1 的转录活性，EC50为 0.06 μM。该化合物可激活人类的 NBRE、NurRE 和 DR5 反应元件，EC50分别为 0.07 μM、0.027 μM 和 0.014 μM。Nurr1 agonist 12 能诱导 Nurr1 调控的神经营养基因表达，如酪氨酸羟化酶 (TH)、SOD1/2、BDNF、Sestrin 3 和 BIRC5（Survivin），此外，对于 Paraquat 引起的神经毒性，也表现出神经保护作用。

Reduced haloperidol is an active metabolite of haloperidol . It is formed via reduction of haloperidol by ketone reductase. Reduced haloperidol inhibits radioligand binding to sigma-1 and dopamine D2 receptors (Kis = 1.4 and 31 nM, respectively) and stimulates brain-derived neurotrophic factor (BDNF) secretion from CCF-SSTG1 and U87MG astrocytic glial cells. It also inhibits norepinephrine, dopamine, and serotonin (5-HT) reuptake (Kis = 21, 25, and 33 μM, respectively, in COS-7 cells expressing the human transporters). Reduced haloperidol (0.5 mg kg) increases latency to paw withdrawal in mouse models of capsaicin- but not force-induced mechanical hypersensitivity.