bdnf (human)

Member of the neurotrophin growth factor family that binds and activates TrkB and p75 neurotrophin receptors. Enhances the survival, growth and differentiation of neurons. BDNF expression is altered in neurodegenerative disorders such as Parkinson's and A

Nurr1 agonist 12 (Compound 37) 是一种激活核受体相关蛋白 1 (Nurr1) 的激动剂，能增强 Nurr1 的转录活性，EC50为 0.06 μM。该化合物可激活人类的 NBRE、NurRE 和 DR5 反应元件，EC50分别为 0.07 μM、0.027 μM 和 0.014 μM。Nurr1 agonist 12 能诱导 Nurr1 调控的神经营养基因表达，如酪氨酸羟化酶 (TH)、SOD1/2、BDNF、Sestrin 3 和 BIRC5（Survivin），此外，对于 Paraquat 引起的神经毒性，也表现出神经保护作用。

Reduced haloperidol is an active metabolite of haloperidol . It is formed via reduction of haloperidol by ketone reductase. Reduced haloperidol inhibits radioligand binding to sigma-1 and dopamine D2 receptors (Kis = 1.4 and 31 nM, respectively) and stimulates brain-derived neurotrophic factor (BDNF) secretion from CCF-SSTG1 and U87MG astrocytic glial cells. It also inhibits norepinephrine, dopamine, and serotonin (5-HT) reuptake (Kis = 21, 25, and 33 μM, respectively, in COS-7 cells expressing the human transporters). Reduced haloperidol (0.5 mg/kg) increases latency to paw withdrawal in mouse models of capsaicin- but not force-induced mechanical hypersensitivity.

Reduced Haloperidol (Standard) 是一种可用于分析的标准物质，通常用作 Reduced Haloperidol 的研究和分析中参考的标准样品。Reduced haloperidol 是氟哌啶醇的一种活性代谢产物。它是通过酮还原酶对氟哌啶醇进行还原反应而形成的。Reduced haloperidol 能够抑制放射性配体与σ-1受体和多巴胺D2受体的结合（其亲和力分别为 1.4 和 31 纳摩尔），并刺激来自 CCF-SSTG1 和 U87MG 星形胶质细胞的脑源性神经营养因子（BDNF）的分泌。它还能抑制去甲肾上腺素、多巴胺和血清素（5-HT）的再摄取（在表达人类转运蛋白的 COS-7 细胞中，其亲和力分别为 21、25 和 33 微摩尔）。