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Search Results for " dynamin "
Targets Recommended: Dynamin GTPase

25

抑制剂 & 化合物

1

天然产物

3

重组蛋白

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Cat. No. Product Name Target Signaling Pathways
T21798L Dynamin inhibitory peptide Acetate

Dynamin inhibitory peptide Acetate(251634-21-6 Free base)

GTPase GPCR/G Protein
Dynamin inhibitory peptide Acetate 是一种具有序列 Gln-Val-Pro-Ser-Arg-Pro-Asn-Arg-Ala-Pro 的肽,可抑制 GTPase dynamin
TP1907L1 Dynamin inhibitory peptide, myristoylated acetate

Dynamin inhibitory peptide, myristoylated acetate(251634-22-7 free base)

Dynamin Cytoskeletal Signaling
Dynamin inhibitory peptide, myristoylated acetate(251634-22-7 free base) 是一种 DynaMin 抑制剂,可干扰两性霉素与 dynamin 的结合。 DynaMin 抑制肽,肉豆蔻酰化 TFA 是肽的膜渗透形式,可防止内吞作用。
T64369 Dynamin IN-2

Dynamin Cytoskeletal Signaling
Dynamin IN-2是一种Wiskostatin 类似物。Dynamin IN-2有效抑制 dynamin ,对 dynamin I GTPase 的 IC50 为 1.0 μM。Dynamin IN-2 可阻断网格蛋白介导的内吞作用 (CME),IC50 为 9.5 μM。
T1848 Dynasore

Dynamin Inhibitor I

Dynamin; Virus Protease; Autophagy; HSV Autophagy; Cytoskeletal Signaling; Microbiology/Virology
Dynasore (Dynamin Inhibitor I) 是一种可渗透细胞的化学物质,可逆且非竞争性地抑制 dynamin 1/2 的 GTPase 活性。 它还抑制线粒体动力蛋白 Drp1,对其他小 GTPase 没有影响。
TP1907 DynaMin inhibitory peptide, myristoylated

Cell-permeable version of dynamin inhibitory peptide, an inhibitor of the GTPase dynamin that competitively blocks binding of dynamin to amphiphysin, preventing endocytosis. Reduces NMDA receptor internalization.
TP2039 Dynamin inhibitory peptide, myristoylated (control)

Control peptide version of dynamin inhibitory peptide, myristoylated, an inhibitor of the GTPase dynamin that competitively blocks binding of dynamin to amphiphysin, preventing endocytosis. In contrast to dynamin inhibitory peptide, has no significant eff
T72952 Dynamin IN-1

Others Others
DynaminIN-1 是一种有效的dynamin 抑制剂,IC50值为 1.0 µM。
T75796 Dynamin inhibitory peptide TFA

Dynamininhibitory peptide TFA 竞争性地阻止了动力蛋白 (dynamin) 与两性纤维蛋白的结合,从而防止了内吞作用。Dynamininhibitory peptide TFA 阻断多巴胺 D3对 GABAA 受体的作用。
T6822 Hydroxy-Dynasore

Dyngo-4a

Dynamin Cytoskeletal Signaling
Hydroxy-Dynasore (Dyngo-4a) 是 Dynasore 结构模拟类似物,是一种改进的,低细胞毒性的 dynamin 通用抑制剂,抑制 dynamin 依赖性转铁蛋白的内吞作用的 IC50为 5.7 μM,对大脑重组 dynamin I 和重组鼠 dynamin II 的 IC50值分别为 0.38 μM 和 2.3μM。
T1907 Mdivi-1

Mitochondrial division inhibitor 1

Apoptosis; Mitophagy; Dynamin; Autophagy Apoptosis; Autophagy; Cytoskeletal Signaling
Mdivi-1 (Mitochondrial division inhibitor 1) 是一种线粒体分裂抑制剂,抑制 DRP1 和 Dynamin I (IC50=1-10 μM)。Mdivi-1 可以抑制线粒体自噬。
T22445 Trimethyloctadecylammonium bromide

Dynamin Cytoskeletal Signaling
Trimethyloctadecylammonium bromide 是 Dynamin I 的抑制剂 (IC50 : 1.9 μM),也抑制 Dynamin Ⅱ。
TP1947L P110 TFA

Others Others
P110 TFA 是一种 dynamin-related protein 1 (Drp1) 抑制剂,抑制 Drp1 GTPase 活性。
T30479 Bis-T-23

Bis T-23,Bis-T 23,AG1717

HIV Protease Microbiology/Virology; Proteases/Proteasome
Bis-T-23是一种肌动蛋白依赖性达纳敏低聚物的促进剂,是一种 HIV-I 整合酶抑制剂,是泰尔普斯丁衍生物。Bis-T-23可以促进肌动蛋白依赖性的dynamin 寡聚化。Bis-T-23可用于HIV 和慢性肾脏疾病(CKD)的研究。
T22981 Tetradecyltrimethylammonium bromide

MitMAB,Cetrimide,tetradecyl trimethyl ammonium bromide,十四烷基三甲基溴化铵

Dynamin Cytoskeletal Signaling
Tetradecyltrimethylammonium bromide (MitMAB) 是一种具有不对称结构的阳离子表面活性剂,是一种有机结构单元。
T35548 Dynapyrazole A

Dynamin Cytoskeletal Signaling
Dynapyrazole A 是微管动力蛋白的特异性抑制剂,对动力蛋白 1 和动力蛋白 2 依赖性微管滑动的 IC50 分别为 2.3 和 2.6 μM。 Dynapyrazole A 抑制 Hedgehog 信号传导,IC50 为 1.9 μM。
T77772 MiTMAB

Others Others
MiTMAB,一种选择性动力蛋白(dynamin)抑制剂,其作用机制为靶向动力蛋白与磷脂之间的相互作用。该抑制剂能够抑制dynamin GTPase活性,Ki值为940 nM。
T38407 RTIL 13

Others Others
RTIL 13 is a highly effective inhibitor of dynamin GTPase, exhibiting an IC50 value of 2.3 μM for dynamin I GTPase. Furthermore, it selectively interacts with the pleckstrin homology lipid binding domain. This compound effectively suppresses both receptor-mediated and synaptic vesicle endocytosis, demonstrating IC50 values of 9.3 μM and 7.1 μM, respectively.
T22754 Dynole 34-2

Others Others
Dynamin I inhibitor
T37023 MB 0223

Others Others
Dynamin-related GTPase DRP1 partial inhibitor (IC50 = 1.2 μM). Selective for DRP1 over other dynamin-related GTPases, OPA1 and DYN1. Increases mitochondrial DNA levels in mfn1- knockout MEFs deficient in mitochondrial fusion. Mallat et al (2018) Discovery and characterization of selective small molecule inhibitors of the mammalian mitochondrial division dynamin, DRP1. Biochem.Biophys.Res.Commun. 499 556 PMID:29601815
T61488 Dynole 2-24

Others Others
Dynole 2 24 是一种基于吲哚的dynamin GTPase 抑制剂 (对 dynamin I 的IC50=0.56 μM)。Dynole 2 24 无毒,在体外和细胞内显示出增强的抗动力蛋白I 和II 的效力 (IC (CME)=1.9 μM)。Dynole 2 24 对 dynamin I 的选择性为4.4倍。Dynole 2 24在网格蛋白介导的内吞作用的细胞抑制剂中具有活性。CME: Clathrin mediated endocytosis
TP1947 P110

Dynamin-related protein 1 (Drp1) inhibitor, inhibits Drp1 GTPase activity. Displays no effect on dynamin 1 or other mitochondrial dynamics-related proteins. Inhibits mitochondrial fission, dysfunction and reactive oxygen species (ROS) production in vitro.
T83891 Sulfonadyn-47

Others Others
Sulfonadyn-47是一种dynamin抑制剂,能在无细胞测定中抑制dynamin的GTP酶活性(IC50 = 3.5 µM)。在U2OS细胞中,Sulfonadyn-47抑制clathrin介导的内吞作用(IC50 = 27.3 µM),同时在分离的大鼠脑突触体中抑制由去极化刺激的FM4-64摄取,后者是突触小泡内吞(SVE)的标志(IC50 = 12.3 µM)。在体内,Sulfonadyn-47(30和60 mg/kg)在6 Hz角膜电引发小鼠癫痫模型中具有抗惊厥活性。
T72894 Clathrin-IN-2

Others Others
Clathrin-IN-2 是网格蛋白介导的内吞作用(CME)的有效抑制剂,IC50值为 2.3 μM。 Clathrin-IN-2 还对dyn I GTPase 具有抑制作用,IC50值为 7.7 μM。
T73456 DRP1i27

Others Others
DRP1i27是一种有效抑制人源Drp1(动力蛋白相关蛋白1)的化合物。它通过与Drp1的GTPase位点结合,并与Gln34及Asp218形成氢键来发挥作用。DRP1i27主要针对Drp1介导的线粒体裂变细胞系模型,能有效防止模拟缺血再灌注引起的损伤。
T68788 Ellipticine quinone

Others Others
Ellipticine quinone, also known as NSC-383230, is a Drp1 inhibitor. rpitor1 and Drpitor1a inhibited the GTPase activity of Drp1 without inhibiting the GTPase of dynamin 1. Ellipticine quinone showed greater potency than the current std. Drp1 GTPase inhibitor, mdivi-​1, (IC50 for mitochondrial fragmentation are (0.06, and 10 μM, resp.)​. Ellipticine quinone suppressed lung cancer tumor growth in a mouse xenograft model. Ellipticine quinone also inhibited mitochondrial ROS prodn., prevented mi...

化合物

Dynamin inhibitory peptide Acetate
Cat.No: T21798L
Synonym: Dynamin inhibitory peptide Acetate(251634-21-6 Free base)
Target: GTPase
Dynamin inhibitory peptide, myristoylated acetate
Cat.No: TP1907L1
Synonym: Dynamin inhibitory peptide, myristoylated acetate(251634-22-7 free base)
Target: Dynamin
Dynamin IN-2
Cat.No: T64369
Synonym:
Target: Dynamin
Dynasore
Cat.No: T1848
Synonym: Dynamin Inhibitor I
Target: Dynamin, Virus Protease, Autophagy, HSV
DynaMin inhibitory peptide, myristoylated
Cat.No: TP1907
Synonym:
Target:
Dynamin inhibitory peptide, myristoylated (control)
Cat.No: TP2039
Synonym:
Target:
Dynamin IN-1
Cat.No: T72952
Synonym:
Target: Others
Dynamin inhibitory peptide TFA
Cat.No: T75796
Synonym:
Target:
Hydroxy-Dynasore
Cat.No: T6822
Synonym: Dyngo-4a
Target: Dynamin
Mdivi-1
Cat.No: T1907
Synonym: Mitochondrial division inhibitor 1
Target: Apoptosis, Mitophagy, Dynamin, Autophagy
Trimethyloctadecylammonium bromide
Cat.No: T22445
Synonym:
Target: Dynamin
P110 TFA
Cat.No: TP1947L
Synonym:
Target: Others
Bis-T-23
Cat.No: T30479
Synonym: Bis T-23,Bis-T 23,AG1717
Target: HIV Protease
Tetradecyltrimethylammonium bromide
Cat.No: T22981
Synonym: MitMAB,Cetrimide,tetradecyl trimethyl ammonium bromide,十四烷基三甲基溴化铵
Target: Dynamin
Dynapyrazole A
Cat.No: T35548
Synonym:
Target: Dynamin
MiTMAB
Cat.No: T77772
Synonym:
Target: Others
RTIL 13
Cat.No: T38407
Synonym:
Target: Others
Dynole 34-2
Cat.No: T22754
Synonym:
Target: Others
MB 0223
Cat.No: T37023
Synonym:
Target: Others
Dynole 2-24
Cat.No: T61488
Synonym:
Target: Others
P110
Cat.No: TP1947
Synonym:
Target:
Sulfonadyn-47
Cat.No: T83891
Synonym:
Target: Others
Clathrin-IN-2
Cat.No: T72894
Synonym:
Target: Others
DRP1i27
Cat.No: T73456
Synonym:
Target: Others
Ellipticine quinone
Cat.No: T68788
Synonym:
Target: Others
Cat. No. Product Name Target Signaling Pathways
T3898 Schaftoside

夏佛塔苷,APIGENIN-6-GLUCOSIDE-8-ARABINOSIDE,Shaftoside

Dynamin; Antioxidant; TLR; MyD88; Mitochondrial Metabolism; Autophagy Autophagy; Cytoskeletal Signaling; Immunology/Inflammation; Metabolism; oxidation-reduction
Schaftoside (APIGENIN-6-GLUCOSIDE-8-ARABINOSIDE) 是在多种中草药中发现的一种黄酮类天然产物。它抑制 TLR4 和 Myd88 表达,还降低 Drp1 表达和磷酸化,并减少线粒体分裂,具有抗氧化和抗癌活性。

天然产物

Schaftoside
Cat.No: T3898
Synonym: 夏佛塔苷,APIGENIN-6-GLUCOSIDE-8-ARABINOSIDE,Shaftoside
Target: Dynamin, Antioxidant, TLR, MyD88, Mitochondrial Metabolism, Autophagy
Cat. No. Product Name Species Expression System
TMPH-01254 DNM1 Protein, Human, Recombinant (His)

DNM,Dynamin,Dynamin-1,DNM1,Dynamin

Human E. coli
Microtubule-associated force-producing protein involved in producing microtubule bundles and able to bind and hydrolyze GTP. Most probably involved in vesicular trafficking processes. Involved in receptor-mediated endocytosis. DNM1 Protein, Human, Recombinant (His) is expressed in E. coli expression system with N-6xHis tag. The predicted molecular weight is 32.2 kDa and the accession number is Q05193.
TMPH-01255 DNM1L Protein, Human, Recombinant (His & Myc)

Dynamin-like protein IV,Dynamin-related pr...

Human E. coli
DNM1L Protein, Human, Recombinant (His & Myc) is expressed in E. coli expression system with N-10xHis and C-Myc tag. The predicted molecular weight is 84.4 kDa and the accession number is O00429.
TMPY-03439 UBASH3A Protein, Human, Recombinant (aa 354-623, His)

TULA,STS-2,CLIP4,ubiquitin associated and SH3 domain contain...

Human E. coli
UBASH3A is a member of the T-cell ubiquitin ligand (TULA) family. This family consists of two members. Both of them can negatively regulate T-cell signaling. UBASH3A can facilitate growth factor withdrawal-induced apoptosis in T cells, which may occur via its interaction with AIF, an apoptosis-inducing factor. Alternative splicing of UBASH3A gene results in multiple transcript variants. It interferes with CBL-mediated down-regulation and degradation of receptor-type tyrosine kinases. UBASH3A pro...

重组蛋白

DNM1 Protein, Human, Recombinant (His)
Cat.No: TMPH-01254
Species: Human
Expression System: E. coli
DNM1L Protein, Human, Recombinant (His & Myc)
Cat.No: TMPH-01255
Species: Human
Expression System: E. coli
UBASH3A Protein, Human, Recombinant (aa 354-623, His)
Cat.No: TMPY-03439
Species: Human
Expression System: E. coli
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