tobramycin

Tobramycin (NSC-180514) 是一种胃肠外给药的广谱氨基糖苷类抗生素，可研究由于敏感生物引起的中度至重度细菌感染疾病。

Tobramycin Sulfate (Dartobcin) 是一种具有抗菌活性的纳米抗生素，可用于研究儿童细菌性肺炎。

5'-Guanylic acid disodium salt (GMP-5) 由鸟嘌呤，核糖和磷酸组成，是信使 RNA 中的一种核苷酸单体。 鸟苷衍生物参与细胞内信号转导，并已鉴定存在于端粒，核糖体 DNA，免疫球蛋白重链转换区和原癌基因的控制区中的重复基因组序列中。

Antibacterial agent 247 (compound 30b) 作为一种高效的细菌 (bacterial) 拮抗剂，能够明显抑制铜绿假单胞菌生物膜的生成，其半抑制浓度（IC50）为5.8 μM，并针对多个毒力表型展现出抑制效果。此外，该化合物还能加强妥布霉素与多粘菌素B的联合治疗效果，提升其抗菌活性。

Paromomycin (Sulfate Salt) is an aminoglycoside that is active against Gram-negative and many Gram-positive bacteria as well as some protozoa and cestodes. Paromomycin in combination with sodium stibogluconate has proven to be effective in African and Indian VL (visceral leishmaniasis) and improves survival in African VL[3]. PS (Paromomycin Sulfate) is effective for elimination of B. coli without hematological side effects[4]. The activity of phosphoglucose isomerase was slightly inhibited by 10(-3) M paromomycin sulfate while those of hexokinase, phosphofructokinase and glucose-6-phosphate dehydrogenase were not inhibited[5]. In addition, with regard to correlation of endotoxemia with renal impairment, endogenous creatinine clearance and p-aminohippurate clearance were significantly improved (P less than 0.02) in those patients whose endotoxemia disappeared on paromomycin sulfate administration. Paromomycin sulfate seems to be effective in the prevention of endotoxemia and the associated renal impairment in cirrhosis in man[6]. Significantly higher frequencies of resistance to paromomycin, kanamycin, neomycin and tobramycin were observed in S. aureus isolates from PS (paromomycin supplemented) birds. Paromomycin supplementation resulted in resistance to aminoglycosides in bacteria of PS turkeys. Co-selection for resistance to other antimicrobial agents was observed in E. coli isolates[7].

Sodium 1-octanesulfonate monohydrate, 97%(T) 是一种离子对试剂，具有阴离子表面活性剂的特性，可与氨基被质子化的Tobramycin 分子相互作用。