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4,5-Dibromo-1H-Pyrrole-2-Carboxylic Acid
一键复制产品信息
很棒纯度: 96.06%
货号 TN7172Cas号 34649-21-3
别名 5-溴-1H-吡咯-2-羧酸, 4,5-dibromopyrrole-2-carboxylic acid, 4,5-Dibromo-2-pyrrolic acid
4,5-Dibromo-1H-Pyrrole-2-Carboxylic Acid (4,5-Dibromo-2-pyrrolic acid) 是一种海洋来源的天然产物，存在于Agelas oroides。
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4,5-Dibromo-1H-Pyrrole-2-Carboxylic Acid
一键复制产品信息 很棒纯度: 96.06%
货号 TN7172 别名 5-溴-1H-吡咯-2-羧酸, 4,5-dibromopyrrole-2-carboxylic acid, 4,5-Dibromo-2-pyrrolic acidCas号 34649-21-3
4,5-Dibromo-1H-Pyrrole-2-Carboxylic Acid (4,5-Dibromo-2-pyrrolic acid) 是一种海洋来源的天然产物，存在于Agelas oroides。
| 规格 | 价格 | 库存 | 数量 |
|---|---|---|---|
| 5 mg | ¥ 287 | 现货 | |
| 10 mg | ¥ 428 | 现货 | |
| 25 mg | ¥ 735 | 现货 | |
| 50 mg | ¥ 1,097 | 待询 | |
| 100 mg | ¥ 1,653 | 待询 | |
| 200 mg | ¥ 2,479 | 待询 |
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产品介绍
4,5-Dibromo-1H-Pyrrole-2-Carboxylic Acid AI Summary
4,5-Dibromo-1H-Pyrrole-2-Carboxylic Acid exhibits a range of bioactivities, including inhibition of Plasmodium falciparum FabI with an IC50 greater than 100.0 µg/mL and antimalarial activity against chloroquine-resistant and pyrimethamine-resistant Plasmodium falciparum K1 with an IC50 greater than 50.0 µg/mL after 48 hours. It also shows antitrypanosomal activity against Trypanosoma brucei rhodesiense with an IC50 of 20.9 µg/mL after 72 hours and limited activity against Trypanosoma cruzi with an IC50 greater than 30.0 µg/mL after 72 hours. Additionally, 4,5-Dibromo-1H-Pyrrole-2-Carboxylic Acid has antileishmanial activity against Leishmania donovani with an IC50 of 7.9 µg/mL after 72 hours and cytotoxicity against rat L6 cells with an IC50 greater than 90.0 µg/mL after 72 hours.
Moreover, 4,5-Dibromo-1H-Pyrrole-2-Carboxylic Acid demonstrates strong immunosuppressive activity against mouse splenocytes by inhibiting [3H]thymidine incorporation up to 100% at concentrations of up to 15.6 µg/mL, with the activity decreasing gradually at higher concentrations. It also exhibits cytotoxicity against mouse splenocytes, as determined by the MTT assay, showing high levels of cell viability inhibition, notably exceeding 100% at lower concentrations, such as 0.5 µg/mL..
Note: Summary generated by AI. Data source: ChEMBL 
生物活性
化学信息
储存&溶解度
| 产品描述 | 4,5-Dibromo-1H-Pyrrole-2-Carboxylic Acid (4,5-Dibromo-2-pyrrolic acid) is a marine derived natural products found in Agelas oroides. |
| 别名 | 5-溴-1H-吡咯-2-羧酸, 4,5-dibromopyrrole-2-carboxylic acid, 4,5-Dibromo-2-pyrrolic acid |
| 分子量 | 268.89 |
| 分子式 | C5H3Br2NO2 |
| CAS No. | 34649-21-3 |
| Smiles | OC(=O)C1=CC(Br)=C(Br)N1 |
| 存储 | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. | ||||||||||||||||||||
| 溶解度信息 | DMSO: 2.69 mg/mL (10 mM), Sonication is recommended.  | ||||||||||||||||||||
溶液配制表 | |||||||||||||||||||||
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计算器
体内实验配液计算器
请在以下方框中输入您的动物实验信息后点击计算，可以得到母液配置方法和体内配方的制备方法：
比如您的给药剂量是10 mg/kg，每只动物体重20 g，给药体积100 μL， 一共给药动物10只，您使用的配方为 10% DMSO + 40% PEG300 + 5% Tween 80 + 45% Saline / PBS / ddH2O， 那么您的工作液浓度为2 mg/mL。
母液配置方法：2 mg 药物溶于 100 μL DMSO （ 母液浓度为 20 mg/mL ）, 如您需要配置的浓度超过该产品的溶解度，请先与我们联系。
体内配方的制备方法： 取 100 μL DMSO 母液， 添加 400 μL PEG300 混匀澄清， 再加 50 μL Tween 80, 混匀澄清, 再加 450 μL Saline / PBS / ddH2O 混匀澄清
以上为“体内实验配液计算器”的使用方法举例，并不是具体某个化合物的推荐配制方式，请根据您的实验动物和给药方式选择适当的溶解方案。
剂量转换
对于不同动物的给药剂量换算，您也可以参考 更多
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