5-ht1d receptor

Donitriptan 是一种 5-HT 受体激动剂，对 5-HT1B 和 5-HT1D 的 pKi 分别为 9.4 和 9.3。

AS19 is a potent, selective 5-HT7 receptor agonist (IC50: 0.83 nM; Ki: 0.6 nM). AS19 is selective for 5-HT7 over 5-HT1A, 5-HT1B, 5-HT1D, and 5-HT5A receptors (Kis: 89.7 nM, 490 nM, 6.6 nM and 98.5 nM, respectively).

Frovatriptan succinate hydrate (Frova) 是一种有效、高亲和力、选择性和口服活性的 5-HT1B、HT1D 受体激动剂和中等有效的 5-HT7 受体激动剂，pKi 值分别为 8.6、8.4 和 6.7。它可有效治疗各种偏头痛，包括恶心、呕吐、畏光和畏声等相关症状。

SB-277011 dihydrochloride is a potent, selective, orally bioavailable and brain penetrate antagonist of dopamine D3 receptor(pKis of 8.0, 6.0, <5.2 and 5.9 for D3, D2, 5-HT1B, and 5-HT1D receptors, respectively).

SEP-363856 是一种口服活性和 CNS 活性的精神药物，具有独特的非 D2/5-HT2A 作用机制，发挥其抗精神病样作用，具有治疗精神分裂症的潜力。

SEP-363856 hydrochloride (SEP-856 hydrochloride) 是一种口服活性和 CNS 活性的精神药物，具有独特的非 D2/5-HT2A 作用机制，发挥其抗精神病样作用，具有治疗精神分裂症的潜力。

Alniditan is a receptors agonist of 5-HT1B/1D in HEK 293 cells (IC50: 1.7 and 1.3 nM). For 5-HT1B/1D receptors, the pKi values are 8.96 and 9.40, respectively.

PNU-142633 has anti-migraine efficacy. PNU-142633 is a high affinity and selective 5-HT1D receptor agonist (Kis of 6 nM and > 18 000 nM for human 5-HT1D receptor and human 5-HT1B receptor, respectively).

Donitriptan hydrochloride (Donitriptan monohydrochloride) 是一种有效的高亲和力 5-HT1B/1D 受体激动剂，pKi 分别为 9.4 和 9.3。

SB 243213 是一种可口服且具有选择性的 5-HT2C 受体拮抗剂。SB 243213 具有抗焦虑抗抑郁活性，可用于精神分裂症和运动障碍。

LY 344864 hydrochloride 是选择性的受体激动剂，对5-HT1F 受体具有6 nM(Ki)的亲和力。

Sumatriptan succinate (GR 43175) 是一种5-HT1受体激动剂，可作用于偏头疼的急性治疗。

Zolmitriptan (311C90) 是一种5-HT1B/1D 受体部分激动剂，可用于偏头痛的研究，对 5-HT1B、5-HT1D、5-HT1F 受体的Ki 分别为 5.01、0.63 和 63.09 nM。

Sumatriptan (GR 43175 free base) 是一种可穿过血脑屏障且具有口服活性和高效性的5-羟色胺1（5-HT1） 受体激动剂，具有抗炎活性，对 5-HT1D、5-HT1B 和 5-HT1F 受体具有较高亲和力，可用于急性偏头痛和急性心肌梗死。

PRX-07034 hydrochloride 是一种有效的高度选择性5-HT6受体拮抗剂，Ki 为 4-8 nM，IC50为 19 nM，可用于增强工作记忆和认知灵活性的研究。

Eletriptan, second-generation triptans used to treat migraines, is used as an abortion drug.

AP521 is an agonist of the human 5-HT1A receptor (IC50: 94 nM).

AR-A 2 is a selective 5-HT1B receptor antagonist, with a high affinity to guinea pig cortex 5HT1B/1D and recombinant guinea pig 5-HT1B receptors (Ki: 0.24 and 0.47 nM) and with 10-fold lower affinity to guinea pig 5-HT1D receptor (Ki: 5 nM).

SB 243213 hydrochloride is an orally active, selective and high-affinity antagonist of 5-hydroxytryptamine (5-HT)2C receptor(pKi of 9.37 and a pKb of 9.8).It has improved anxiolytic profile and has the potential for schizophrenia and motor disorders.

SB 243213 dihydrochloride is an orally active, selective and high-affinity antagonist of 5-hydroxytryptamine (5-HT)2C receptor(pKi of 9.37 and a pKb of 9.8 for human 5-HT2C receptor).

SEP-363856 (SEP-856) mesylate 为一种具备口服活性的抗精神病化合物，激活TAAR1与5-HT1A受体，显示出治疗精神分裂症的研究潜力。此化合物在中枢神经系统中展现活性。

CP 135807 is a 5-HT1D receptor agonist.

5-HT1B/1D receptor antagonist

β-adrenoceptor and 5-HT1A/1B receptor antagonist