Nampt activator-1

Name: Nampt activator-1
Brand: TargetMol
SKU: T67925
Price: 256 CNY
Availability: InStock
Rating: 5 (10 reviews)

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纯度: 99.98%

货号 T67925Cas号 701929-65-9

NAMPT activator-1 (compound 1) 是一种有效的、专用范围广泛的烟酰胺磷酸基转移酶 (NAMPT) 激活剂(EC50 为3.3-3.7 μM)。NAMPT activator-1能有效保护培养细胞免受 fk866介导的毒性，是神经保护的潜在化合物。

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Nampt activator-1

一键复制产品信息

很棒

纯度: 99.98%

货号 T67925Cas号 701929-65-9

规格	价格	库存
1 mg	¥ 256	现货
5 mg	¥ 596	现货
10 mg	¥ 928	现货
25 mg	¥ 1,790	现货
50 mg	¥ 2,780	现货
100 mg	¥ 4,490	现货
200 mg	¥ 6,330	现货
1 mL x 10 mM (in DMSO)	¥ 655	现货

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产品介绍

Nampt activator-1 AI Summary

Nampt activator-1 shows various bioactivities as follows: - It inhibits the MLL CXXC domain-DNA interaction with a potency of 15848.9 nM. - Demonstrates inhibitory activity on the Influenza NS1 Protein with a potency of 281.8 nM. - Exhibits inhibitory and activator activity on Human alpha-Glucosidase for the potential treatment of Pompe Disease, both with a potency of 56234.1 nM. - Inhibits BAZ2B with a potency of 707.9 nM. - Shows delayed death inhibitory effect on the malarial parasite plastid with a potency of 11689.1 nM. - Inhibits Polymerase Iota with a potency of 100000.0 nM and TGF-b with a potency of 3981.1 nM. - Acts as an inverse agonist on the GLP-1 Receptor with a potency of 28183.8 nM. - Works as an agonist for the gsp mutation responsible for Fibrous Dysplasia/McCune-Albright Syndrome with a potency of 35481.3 nM. - Activates integrin-mediated alleviation for Muscular Dystrophy with a potency of 1122.0 nM. - Inhibits human tyrosyl-DNA phosphodiesterase 1 (TDP1) with a potency of 3662.6 nM. - Inhibits MBNL1-poly(CUG) RNA binding with a potency of 63095.7 nM. - Activates human NAMPT, leading to an increase in NMN production with an EC50 of approximately 3250.0 nM and a maximum increase of 75-98% relative to control or a reference compound at specific concentrations..

Note: Summary generated by AI. Data source: ChEMBL

生物活性

产品描述	NAMPT Activator-1 (compound 1) is an effective and specific activator of niacinamide phosphotransferase (Compound 1) with a wide range of EC50 (3.3-3.7 μM). NAMPT activator-1 effectively protects cultured cells from FK866-mediated toxicity and is a potential neuroprotective compound.
靶点活性	NAMPT:3.3-3.7 μM (EC50)

化学信息

分子量	299.32
分子式	C₁₆H₁₇N₃O₃
CAS No.	701929-65-9
Smiles	CCOC(=O)c1ccc(NC(=O)NCc2ccncc2)cc1
密度	1.248 g/cm3 (Predicted)

储存&溶解度

存储

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

溶解度信息

DMSO: 225 mg/mL (751.7 mM), Sonication is recommended.

体内实验配方

10% DMSO+90% Corn Oil: 3.3 mg/mL (11.02 mM), Sonication is recommeded.

请按顺序添加溶剂，在添加下一种溶剂之前，尽可能使溶液澄清。如有必要，可通过加热、超声、涡旋处理进行溶解。工作液建议现配现用。以上配方仅供参考，体内配方并不是绝对的，请根据不同情况进行调整。

溶液配制表

DMSO

	1mg	5mg	10mg	50mg
1 mM	3.3409 mL	16.7045 mL	33.4091 mL	167.0453 mL
5 mM	0.6682 mL	3.3409 mL	6.6818 mL	33.4091 mL
10 mM	0.3341 mL	1.6705 mL	3.3409 mL	16.7045 mL
20 mM	0.1670 mL	0.8352 mL	1.6705 mL	8.3523 mL
50 mM	0.0668 mL	0.3341 mL	0.6682 mL	3.3409 mL
100 mM	0.0334 mL	0.1670 mL	0.3341 mL	1.6705 mL