LSN3318839

Name: LSN3318839
Brand: TargetMol
SKU: T63166
Price: 1730 CNY
Availability: InStock
Rating: 5 (10 reviews)

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很棒

纯度: 99.70%

货号 T63166Cas号 2764704-18-7

别名 LSN-3318839, LSN 3318839

LSN3318839 是一种有效且可口服的胰高血糖素样肽-1受体（GLP-1R）变构调节剂。LSN3318839可增强GLP-1R的G蛋白偶联信号传导，可用来降低血糖。

LSN3318839

一键复制产品信息

很棒

纯度: 99.70%

货号 T63166 别名 LSN-3318839, LSN 3318839Cas号 2764704-18-7

LSN3318839 是一种有效且可口服的胰高血糖素样肽-1受体（GLP-1R）变构调节剂。LSN3318839可增强GLP-1R的G蛋白偶联信号传导，可用来降低血糖。

规格	价格	库存
1 mg	¥ 1,730	现货
5 mg	¥ 4,290	现货
10 mg	¥ 5,970	现货
25 mg	¥ 8,870	现货
50 mg	¥ 12,200	现货
100 mg	¥ 16,300	现货

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纯度: 99.70%

ee: 97.96%

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产品介绍

LSN3318839 AI Summary

LSN3318839 exhibits various bioactivities and pharmacokinetic properties. It functions as a positive allosteric modulator of the human GLP-1R, significantly increasing GLP-1(9-36) induced cAMP accumulation. Additionally, it acts as an agonist, with low EC50 values, for the GLP-1R by potentiating GLP-1(7-36) induced cAMP accumulation. It also shows partial agonist activity, moderately potentiating GLP-1(9-36) induced cAMP accumulation. This compound demonstrates anti-hyperglycemic activity in overnight-fasted GIPR KO C57BL/6 mice, effectively reducing blood glucose AUC at various doses and when used in combination with sitagliptin. It exhibits oral bioavailability and has been characterized by pharmacokinetic parameters such as clearance, half-life, volume of distribution, Cmax, and Tmax in different animal models..

Note: Summary generated by AI. Data source: ChEMBL

生物活性

产品描述	LSN3318839 is a potent and orally available glucagon-like peptide-1 receptor (GLP-1R) modulator.LSN3318839 enhances GLP-1R G-protein-coupled signaling and can be used to lower blood glucose.
别名	LSN-3318839, LSN 3318839

化学信息

分子量	480.39
分子式	C₂₆H₂₃Cl₂N₃O₂
CAS No.	2764704-18-7
Smiles	[C@H](C)(N1C=2C(N=C1)=CN=C(C2)C3=C([C@H](C(O)=O)C)C=CC=C3)C4=C(Cl)C(=CC=C4Cl)C5CC5
颜色	Yellow
物理性状	Solid

储存&溶解度

存储

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

溶解度信息

DMSO: 255 mg/mL (530.82 mM), Sonication is recommended.

溶液配制表

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.0816 mL	10.4082 mL	20.8164 mL	104.0821 mL
5 mM	0.4163 mL	2.0816 mL	4.1633 mL	20.8164 mL
10 mM	0.2082 mL	1.0408 mL	2.0816 mL	10.4082 mL
20 mM	0.1041 mL	0.5204 mL	1.0408 mL	5.2041 mL
50 mM	0.0416 mL	0.2082 mL	0.4163 mL	2.0816 mL
100 mM	0.0208 mL	0.1041 mL	0.2082 mL	1.0408 mL