Isonipecotic acid

Name: Isonipecotic acid
Brand: TargetMol
SKU: T22348
Price: 99 CNY
Availability: InStock
Rating: 5 (10 reviews)

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很棒

纯度: 99.82%

货号 T22348Cas号 498-94-2

别名 Hexahydroisonicotinic acid, 4-哌啶甲酸, 4-Piperidinecarboxylic acid, 4-Carboxypiperidine

Isonipecotic acid (4-Piperidinecarboxylic acid) 是一种杂环化合物。它主要表征为 GABAA 受体部分激动剂。

Isonipecotic acid

一键复制产品信息

很棒

纯度: 99.82%

货号 T22348 别名 Hexahydroisonicotinic acid, 4-哌啶甲酸, 4-Piperidinecarboxylic acid, 4-CarboxypiperidineCas号 498-94-2

Isonipecotic acid (4-Piperidinecarboxylic acid) 是一种杂环化合物。它主要表征为 GABAA 受体部分激动剂。

规格	价格	库存	数量
1 g	¥ 99	现货

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产品介绍

Isonipecotic acid AI Summary

Isonipecotic acid exhibits a wide range of bioactivities. It acts as an agonist on human Gamma-aminobutyric acid A (GABAA) receptor subtypes, demonstrating varying potency (EC50 values) on subtypes such as alpha-1-beta-3-gamma-2, alpha-2-beta-3-gamma-2, alpha-3-beta-3-gamma-2, alpha-4-beta-3-gamma-2, alpha-5-beta-3-gamma-2, and alpha-6-beta-3-gamma-2. It also shows agonist activity against the GABA-C receptor derived from bovine retinal RNA with a binding affinity (Kb) greater than 100,000 nM and significant inhibitory effects on GABA binding in rat brain synaptosomal membranes with an IC50 of 330 nM. Despite its extensive receptor interactions, Isonipecotic acid shows weak anticonvulsive activity in the bicuculline (BIC) test, with an effective dose (ED50) of greater than 1000 umol.kg-1. Additionally, it demonstrates inhibitory activity against the N-methyl-D-aspartate glutamate receptor 1 with an IC50 of 94100 nM and has distinct effects on the input resistance of cultured spinal cord neurons. Furthermore, Isonipecotic acid exhibits antiplasmodial activity against Plasmodium falciparum with an IC50 of 15848.93 nM and differential inhibition of various Plasmodium falciparum strains. It also modulates activity for several other receptors and enzymes such as Thyroid Stimulating Hormone Receptor, Human Peripheral Myelin Protein 22 (PMP22), Acetylcholine Muscarinic M1 Receptor, and other enzymes like Histone Lysine Methyltransferase G9a and Mammalian Selenoprotein Thioredoxin Reductase 1. Additionally, it shows inhibition of virus entry for Lassa Virus and Marburg Virus and enhances Arylsulfatase A (ASA1) activity. In terms of neuronal interactions, Isonipecotic acid exhibits moderate affinity for GABAA receptors with Ki values around 500 nM and acts as an agonist at several subtypes with varying EC50 values, demonstrating considerable efficacy compared to GABA. It also moderately inhibits human PAT1-mediated L-[3H]proline uptake in human Caco2 cells with a Ki value of 2300000.0 nM..

Note: Summary generated by AI. Data source: ChEMBL

生物活性

产品描述	Isonipecotic acid (4-Piperidinecarboxylic acid) is a heterocyclic compound. Isonipecotic acid mainly characterized as a GABAA receptor partial agonist.
别名	Hexahydroisonicotinic acid, 4-哌啶甲酸, 4-Piperidinecarboxylic acid, 4-Carboxypiperidine

化学信息

分子量	129.16
分子式	C₆H₁₁NO₂
CAS No.	498-94-2
Smiles	OC(=O)C1CCNCC1
密度	1.125 g/cm3

储存&溶解度

存储

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

溶解度信息

H2O: 25 mg/mL (193.56 mM), Sonication is recommended.

溶液配制表

H2O

	1mg	5mg	10mg	50mg
1 mM	7.7423 mL	38.7117 mL	77.4234 mL	387.1168 mL
5 mM	1.5485 mL	7.7423 mL	15.4847 mL	77.4234 mL
10 mM	0.7742 mL	3.8712 mL	7.7423 mL	38.7117 mL
20 mM	0.3871 mL	1.9356 mL	3.8712 mL	19.3558 mL
50 mM	0.1548 mL	0.7742 mL	1.5485 mL	7.7423 mL
100 mM	0.0774 mL	0.3871 mL	0.7742 mL	3.8712 mL