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顶部相关产品产品介绍化学信息储存和溶解信息计算器

Isonipecotic acid

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纯度: 99.82%

货号 T22348Cas号 498-94-2

别名 Hexahydroisonicotinic acid, 4-哌啶甲酸, 4-Piperidinecarboxylic acid, 4-Carboxypiperidine

Isonipecotic acid (4-Piperidinecarboxylic acid) 是一种杂环化合物。它主要表征为 GABAA 受体部分激动剂。

Isonipecotic acid

Isonipecotic acid

一键复制产品信息
Rating icon 很棒

纯度: 99.82%

货号 T22348 别名 Hexahydroisonicotinic acid, 4-哌啶甲酸, 4-Piperidinecarboxylic acid, 4-CarboxypiperidineCas号 498-94-2

Isonipecotic acid (4-Piperidinecarboxylic acid) 是一种杂环化合物。它主要表征为 GABAA 受体部分激动剂。

规格价格库存数量
1 g
¥ 99
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纯度: 99.82%
颜色: 白色
性状: solid
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产品介绍

Isonipecotic acid AI Summary
Isonipecotic acid exhibits a wide range of bioactivities. It acts as an agonist on human Gamma-aminobutyric acid A (GABAA) receptor subtypes, demonstrating varying potency (EC50 values) on subtypes such as alpha-1-beta-3-gamma-2, alpha-2-beta-3-gamma-2, alpha-3-beta-3-gamma-2, alpha-4-beta-3-gamma-2, alpha-5-beta-3-gamma-2, and alpha-6-beta-3-gamma-2. It also shows agonist activity against the GABA-C receptor derived from bovine retinal RNA with a binding affinity (Kb) greater than 100,000 nM and significant inhibitory effects on GABA binding in rat brain synaptosomal membranes with an IC50 of 330 nM. Despite its extensive receptor interactions, Isonipecotic acid shows weak anticonvulsive activity in the bicuculline (BIC) test, with an effective dose (ED50) of greater than 1000 umol.kg-1. Additionally, it demonstrates inhibitory activity against the N-methyl-D-aspartate glutamate receptor 1 with an IC50 of 94100 nM and has distinct effects on the input resistance of cultured spinal cord neurons. Furthermore, Isonipecotic acid exhibits antiplasmodial activity against Plasmodium falciparum with an IC50 of 15848.93 nM and differential inhibition of various Plasmodium falciparum strains. It also modulates activity for several other receptors and enzymes such as Thyroid Stimulating Hormone Receptor, Human Peripheral Myelin Protein 22 (PMP22), Acetylcholine Muscarinic M1 Receptor, and other enzymes like Histone Lysine Methyltransferase G9a and Mammalian Selenoprotein Thioredoxin Reductase 1. Additionally, it shows inhibition of virus entry for Lassa Virus and Marburg Virus and enhances Arylsulfatase A (ASA1) activity. In terms of neuronal interactions, Isonipecotic acid exhibits moderate affinity for GABAA receptors with Ki values around 500 nM and acts as an agonist at several subtypes with varying EC50 values, demonstrating considerable efficacy compared to GABA. It also moderately inhibits human PAT1-mediated L-[3H]proline uptake in human Caco2 cells with a Ki value of 2300000.0 nM..
Note: Summary generated by AI. Data source: ChEMBL
生物活性
产品描述
Isonipecotic acid (4-Piperidinecarboxylic acid) is a heterocyclic compound. Isonipecotic acid mainly characterized as a GABAA receptor partial agonist.
别名Hexahydroisonicotinic acid, 4-哌啶甲酸, 4-Piperidinecarboxylic acid, 4-Carboxypiperidine
化学信息
分子量129.16
分子式C6H11NO2
CAS No.498-94-2
SmilesOC(=O)C1CCNCC1
密度1.125 g/cm3
储存&溶解度
存储
溶解度信息
H2O: 25 mg/mL (193.56 mM), Sonication is recommended.
溶液配制表
H2O
1mg5mg10mg50mg
1 mM7.7423 mL38.7117 mL77.4234 mL387.1168 mL
5 mM1.5485 mL7.7423 mL15.4847 mL77.4234 mL
10 mM0.7742 mL3.8712 mL7.7423 mL38.7117 mL
20 mM0.3871 mL1.9356 mL3.8712 mL19.3558 mL
50 mM0.1548 mL0.7742 mL1.5485 mL7.7423 mL
100 mM0.0774 mL0.3871 mL0.7742 mL3.8712 mL

计算器

  • 摩尔浓度 计算器
  • 稀释 计算器
  • 配液 计算器
  • 分子量 计算器

体内实验配液计算器

请在以下方框中输入您的动物实验信息后点击计算，可以得到母液配置方法和体内配方的制备方法：
比如您的给药剂量是10 mg/kg，每只动物体重20 g，给药体积100 μL， 一共给药动物10只，您使用的配方为 10% DMSO + 40% PEG300 + 5% Tween 80 + 45% Saline / PBS / ddH2O， 那么您的工作液浓度为2 mg/mL。
母液配置方法：2 mg 药物溶于 100 μL DMSO （ 母液浓度为 20 mg/mL ）, 如您需要配置的浓度超过该产品的溶解度，请先与我们联系。
体内配方的制备方法： 取 100 μL DMSO 母液， 添加 400 μL PEG300 混匀澄清， 再加 50 μL Tween 80, 混匀澄清, 再加 450 μL Saline / PBS / ddH2O 混匀澄清
以上为“体内实验配液计算器”的使用方法举例，并不是具体某个化合物的推荐配制方式，请根据您的实验动物和给药方式选择适当的溶解方案。
方案所需的各类助溶剂如： DMSO， PEG300， PEG400， Tween 80， SBE-β-CD， 玉米油等， 均可在TargetMol网站点击购买。
1 请输入动物实验的基本信息
mg/kg
g
μL
2 请输入动物体内配方组成，不同的产品配方组成不同，如有配方需求，可先联系我们提供正确的体内配方。
% DMSO
%
% Tween 80
% Saline/PBS/ddH2O

剂量转换

对于不同动物的给药剂量换算，您也可以参考 更多

关键词

Isonipecotic acidGABAReceptorGABAAGABA Receptor
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