购物车

您的购物车当前为空

Isonipecotic acid

Name: Isonipecotic acid
Brand: TargetMol
SKU: T22348
Price: 99 CNY
Availability: InStock
Rating: 5 (10 reviews)

Synonyms: Hexahydroisonicotinic acid, 4-哌啶甲酸, 4-Piperidinecarboxylic acid, 4-Carboxypiperidine

货号 T22348Cas号 498-94-2 一键复制产品信息纯度: 99.82%

很棒

Isonipecotic acid (4-Piperidinecarboxylic acid) 是一种杂环化合物。它主要表征为 GABAA 受体部分激动剂。

Isonipecotic acid

一键复制产品信息

很棒

纯度: 99.82%

货号 T22348Cas号 498-94-2

别名 Hexahydroisonicotinic acid, 4-哌啶甲酸, 4-Piperidinecarboxylic acid, 4-Carboxypiperidine

Isonipecotic acid (4-Piperidinecarboxylic acid) 是一种杂环化合物。它主要表征为 GABAA 受体部分激动剂。

规格	价格	库存	数量
1 g	¥ 99	现货

库存状态实时更新，以官网显示为准，现货产品可直接加购物车下单

大包装 & 定制

加入购物车

TargetMol的所有产品仅用作科学研究或药证申报，不能被用于人体，我们不向个人提供产品和服务。请您遵守承诺用途，不得违反法律法规规定用于任何其他用途。

该分子属于定制产品。TargetMol拥有优秀的合成团队，经验和能力，可以为您提供高性价比的产品。如您有任何问题，欢迎咨询，我们将竭诚为您服务。

实验操作小课堂

常见问题解答

选择批次:

纯度: 99.82%

颜色: 白色

性状: solid

资源下载: COA HNMR LCMS产品操作手册

产品介绍

Isonipecotic acid AI Summary

Isonipecotic acid exhibits a wide range of bioactivities. It acts as an agonist on human Gamma-aminobutyric acid A (GABAA) receptor subtypes, demonstrating varying potency (EC50 values) on subtypes such as alpha-1-beta-3-gamma-2, alpha-2-beta-3-gamma-2, alpha-3-beta-3-gamma-2, alpha-4-beta-3-gamma-2, alpha-5-beta-3-gamma-2, and alpha-6-beta-3-gamma-2. It also shows agonist activity against the GABA-C receptor derived from bovine retinal RNA with a binding affinity (Kb) greater than 100,000 nM and significant inhibitory effects on GABA binding in rat brain synaptosomal membranes with an IC50 of 330 nM. Despite its extensive receptor interactions, Isonipecotic acid shows weak anticonvulsive activity in the bicuculline (BIC) test, with an effective dose (ED50) of greater than 1000 umol.kg-1. Additionally, it demonstrates inhibitory activity against the N-methyl-D-aspartate glutamate receptor 1 with an IC50 of 94100 nM and has distinct effects on the input resistance of cultured spinal cord neurons. Furthermore, Isonipecotic acid exhibits antiplasmodial activity against Plasmodium falciparum with an IC50 of 15848.93 nM and differential inhibition of various Plasmodium falciparum strains. It also modulates activity for several other receptors and enzymes such as Thyroid Stimulating Hormone Receptor, Human Peripheral Myelin Protein 22 (PMP22), Acetylcholine Muscarinic M1 Receptor, and other enzymes like Histone Lysine Methyltransferase G9a and Mammalian Selenoprotein Thioredoxin Reductase 1. Additionally, it shows inhibition of virus entry for Lassa Virus and Marburg Virus and enhances Arylsulfatase A (ASA1) activity. In terms of neuronal interactions, Isonipecotic acid exhibits moderate affinity for GABAA receptors with Ki values around 500 nM and acts as an agonist at several subtypes with varying EC50 values, demonstrating considerable efficacy compared to GABA. It also moderately inhibits human PAT1-mediated L-[3H]proline uptake in human Caco2 cells with a Ki value of 2300000.0 nM..

Note: Summary generated by AI. Data source: ChEMBL

生物活性

产品描述	Isonipecotic acid (4-Piperidinecarboxylic acid) is a heterocyclic compound. Isonipecotic acid mainly characterized as a GABAA receptor partial agonist.
别名	Hexahydroisonicotinic acid, 4-哌啶甲酸, 4-Piperidinecarboxylic acid, 4-Carboxypiperidine

化学信息

分子量	129.16
分子式	C₆H₁₁NO₂
CAS No.	498-94-2
Smiles	OC(=O)C1CCNCC1
密度	1.125 g/cm3

储存&溶解度

存储

Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature.

实际储存温度请以COA为准

溶解度信息

H2O: 25 mg/mL (193.56 mM), Sonication is recommended.

溶液配制表

H2O

	1mg	5mg	10mg	50mg
1 mM	7.7423 mL	38.7117 mL	77.4234 mL	387.1168 mL
5 mM	1.5485 mL	7.7423 mL	15.4847 mL	77.4234 mL
10 mM	0.7742 mL	3.8712 mL	7.7423 mL	38.7117 mL
20 mM	0.3871 mL	1.9356 mL	3.8712 mL	19.3558 mL
50 mM	0.1548 mL	0.7742 mL	1.5485 mL	7.7423 mL
100 mM	0.0774 mL	0.3871 mL	0.7742 mL	3.8712 mL

该溶液配制表仅适用于固体产品。对于液体产品，请根据标明的浓度或密度计算稀释方案。

计算器

摩尔浓度计算器
稀释计算器
配液计算器
分子量计算器

体内实验配液计算器

请在以下方框中输入您的动物实验信息后点击计算，可以得到母液配置方法和体内配方的制备方法：

比如您的给药剂量是10 mg/kg，每只动物体重20 g，给药体积100 μL，一共给药动物10只，您使用的配方为 10% DMSO + 40% PEG300 + 5% Tween 80 + 45% Saline / PBS / ddH₂O，那么您的工作液浓度为2 mg/mL。

母液配置方法：2 mg 药物溶于 100 μL DMSO （母液浓度为 20 mg/mL ）, 如您需要配置的浓度超过该产品的溶解度，请先与我们联系。

体内配方的制备方法： 取 100 μL DMSO 母液，添加 400 μL PEG300 混匀澄清，再加 50 μL Tween 80, 混匀澄清, 再加 450 μL Saline / PBS / ddH₂O 混匀澄清

以上为“体内实验配液计算器”的使用方法举例，并不是具体某个化合物的推荐配制方式，请根据您的实验动物和给药方式选择适当的溶解方案。

方案所需的各类助溶剂如： DMSO， PEG300， PEG400， Tween 80， SBE-β-CD，玉米油等，均可在TargetMol网站点击购买。

剂量转换

对于不同动物的给药剂量换算，您也可以参考更多

关键词

Isonipecotic acid GABAReceptor GABAA GABA Receptor

Isonipecotic acid

Isonipecotic acid