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Guanosine 5'-diphosphate

Name: Guanosine 5'-diphosphate
Brand: TargetMol
SKU: T7210
Price: 348 CNY
Availability: InStock
Rating: 5 (10 reviews)

Synonyms: 鸟苷-5ˊ-二磷酸, GDP

货号 T7210Cas号 146-91-8 一键复制产品信息纯度: 99.89%

很棒

Guanosine 5'-diphosphate (GDP) 是核苷二磷酸，是潜在的铁动员剂，能够阻断铁调素-铁转运蛋白相互作用并调节白细胞介素-6 (IL-6)/stat-3 途径。

Guanosine 5'-diphosphate

一键复制产品信息

很棒

纯度: 99.89%

货号 T7210Cas号 146-91-8

别名 鸟苷-5ˊ-二磷酸, GDP

Guanosine 5'-diphosphate (GDP) 是核苷二磷酸，是潜在的铁动员剂，能够阻断铁调素-铁转运蛋白相互作用并调节白细胞介素-6 (IL-6)/stat-3 途径。

规格	价格	库存
5 mg	¥ 348	现货
10 mg	¥ 497	现货
25 mg	¥ 732	现货
50 mg	¥ 867	现货
100 mg	¥ 1,590	现货
200 mg	¥ 2,390	现货
500 mg	¥ 3,970	现货

库存状态实时更新，以官网显示为准，现货产品可直接加购物车下单

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TargetMol的所有产品仅用作科学研究或药证申报，不能被用于人体，我们不向个人提供产品和服务。请您遵守承诺用途，不得违反法律法规规定用于任何其他用途。

实验操作小课堂

常见问题解答

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纯度: 99.89%

颜色: 白色

资源下载: COA HNMR LCMS产品操作手册

产品介绍

Guanosine 5'-diphosphate AI Summary

Guanosine 5'-diphosphate demonstrates a broad spectrum of bioactivities across multiple targets and assays. It inhibits fucosyltransferase enzymes, including Fucosyltransferase 4 alpha 1,3 with an IC50 value of 5000.0 nM, Fucosyltransferase (FucT V) with an IC50 value of 67000.0 nM, and human recombinant alpha1,3-fucosyltransferase 9 with a Ki of 77900.0 nM and an IC50 of 59000.0 nM. Moreover, it inhibits Helicobacter pylori recombinant alpha1,3-fucosyltransferase with an inhibition percentage of up to 75.0%. In addition, it has a binding affinity to Escherichia coli KPR (Kd of 373000.0 nM) and shows an inhibition of 8.5% on Trypanosoma brucei brucei DPMS at 1 mM. In terms of receptor activity, Guanosine 5'-diphosphate acts as an agonist at human recombinant P2Y2, P2Y4, and P2Y6 receptors, with respective EC50 values of 54.0, 90.0, and 45000.0 nM, mediated by PLC and [3H]IP production. It also induces phagocytosis in Wistar rat microglia, showing 49.7% activity at 100 uM over 20 minutes. Furthermore, the compound exhibits bioactivity in several other assays: it enhances SMN2 splice variant expression (potency of 14125.4 nM), inhibits Aldehyde Dehydrogenase 1 (ALDH1A1) with a potency of 2818.4 nM, and inhibits Regulator of G Protein Signaling (RGS) 4 with a potency of 597.3 nM. It also shows binding affinity to Mg2+ ions as determined by 31P NMR analysis with activities of 0.5 and 2.0 equiv, and interacts with various mutants of Rab7 GTPase and wild-type Rab7 with Kd values ranging from 25.83 nM to 109.2 nM, suggesting potential modulatory effects on Rab7 GTPase functions..

Note: Summary generated by AI. Data source: ChEMBL

生物活性

产品描述	Guanosine 5'-diphosphate (GDP) as Potential Iron Mobilizer, Preventing the Hepcidin-Ferroportin Interaction and Modulating the Interleukin-6/Stat-3 Pathway.
别名	鸟苷-5ˊ-二磷酸, GDP

化学信息

分子量	443.2
分子式	C₁₀H₁₅N₅O₁₁P₂
CAS No.	146-91-8
Smiles	O[C@H]1[C@H](N2C3=C(N=C2)C(=O)N=C(N)N3)O[C@H](COP(OP(=O)(O)O)(=O)O)[C@H]1O
密度	2.63 g/cm3 (Predicted)

储存&溶解度

存储

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

实际储存温度请以COA为准

溶解度信息

H2O: 50 mg/mL (112.82 mM), Sonication is recommended.

溶液配制表

H2O

	1mg	5mg	10mg	50mg
1 mM	2.2563 mL	11.2816 mL	22.5632 mL	112.8159 mL
5 mM	0.4513 mL	2.2563 mL	4.5126 mL	22.5632 mL
10 mM	0.2256 mL	1.1282 mL	2.2563 mL	11.2816 mL
20 mM	0.1128 mL	0.5641 mL	1.1282 mL	5.6408 mL
50 mM	0.0451 mL	0.2256 mL	0.4513 mL	2.2563 mL
100 mM	0.0226 mL	0.1128 mL	0.2256 mL	1.1282 mL

该溶液配制表仅适用于固体产品。对于液体产品，请根据标明的浓度或密度计算稀释方案。

计算器

摩尔浓度计算器
稀释计算器
配液计算器
分子量计算器

体内实验配液计算器

请在以下方框中输入您的动物实验信息后点击计算，可以得到母液配置方法和体内配方的制备方法：

比如您的给药剂量是10 mg/kg，每只动物体重20 g，给药体积100 μL，一共给药动物10只，您使用的配方为 10% DMSO + 40% PEG300 + 5% Tween 80 + 45% Saline / PBS / ddH₂O，那么您的工作液浓度为2 mg/mL。

母液配置方法：2 mg 药物溶于 100 μL DMSO （母液浓度为 20 mg/mL ）, 如您需要配置的浓度超过该产品的溶解度，请先与我们联系。

体内配方的制备方法： 取 100 μL DMSO 母液，添加 400 μL PEG300 混匀澄清，再加 50 μL Tween 80, 混匀澄清, 再加 450 μL Saline / PBS / ddH₂O 混匀澄清

以上为“体内实验配液计算器”的使用方法举例，并不是具体某个化合物的推荐配制方式，请根据您的实验动物和给药方式选择适当的溶解方案。

方案所需的各类助溶剂如： DMSO， PEG300， PEG400， Tween 80， SBE-β-CD，玉米油等，均可在TargetMol网站点击购买。

剂量转换

对于不同动物的给药剂量换算，您也可以参考更多

关键词

Potassium Channel KcsA K+ channel Inhibitor inhibit inflammation Human Endogenous Metabolite HepG2 hepcidin Guanosine 5'-diphosphate Guanosine 5'diphosphate Guanosine 5' diphosphate EndogenousMetabolite Endogenous Metabolite Caco-2 anemia

Guanosine 5'-diphosphate

Guanosine 5'-diphosphate