egcg

EGCG Octaacetate 是表没食子儿茶素没食子酸酯的前药，对革兰氏阳性菌和革兰氏阴性菌有潜在抗菌可能。它可下调 PI3K/Akt/NFκB 磷酸化和 p65 乙酰化来降低促炎介质水平，减少小鼠结肠炎引起的结肠癌。

(-)-Epigallocatechin Gallate (EGCG) 属于茶类黄酮天然产物，可抑制 EGFR 信号传导，抑制 GLUD 1/2。(-)-Epigallocatechin Gallate 具有抗氧化、抗炎和抗肿瘤活性。(-)-Epigallocatechin Gallate 可以通过激活细胞色素 c 氧化酶来诱导氧化磷酸化。

Proteasome inhibitor IX (PS-IX) 是 Chalcone 的一种衍生物，对20S 蛋白酶体的胰凝乳蛋白酶样活性有抑制作用，IC50约为 1 μM。它抑制 HCT116 p53+/+细胞生长，IC50为 1.49 μM，显示出有效的抗癌活性。

MST-312 (Telomerase Inhibitor IX) 是绿茶表没食子儿茶素没食子酸酯 (EGCG) 的衍生物。MST-312 是 telomerase 抑制剂，可用于肿瘤的研究，如多发性骨髓瘤 (MM)。

4''-C18 EGCG 具备高效的抑制作用，针对α-淀粉酶和α-葡萄糖苷酶，其 IC50 值分别为 3.74 μM 和 0.81 μM。该化合物通过抑制碳水化合物水解酶来降低氧化应激和炎症，展现出抗糖尿病的活性。此外，4''-C18 EGCG 还能下调促炎细胞因子，对原代人外周血单核细胞 (PBMC)、3T3-L1 和 HEK 293 非癌细胞系的细胞毒性为 50 μM。

EGCG-4″-sulfate，作为绿茶中的主要多酚成分，具有抑制细胞增殖和诱导细胞凋亡的功能。它通过抑制谷氨酸脱氢酶1/2（GDH1/2, GLUD1/2）活性，发挥作用。此外，EGCG-4″-sulfate在对抗结直肠癌、髓性白血病、甲状腺癌等多种癌症中显示出显著的抗癌、抗氧化和抗炎效果[2]。

(-)-Epigallocatechin-3-(3''-O-methyl) gallate ((-)-EGCG-3''-O-ME) 是从茶叶中分离出的一种天然产物，具有很强的抗氧化、细胞毒性和抗菌活性，可增强蚀刻漂洗粘合剂与牙本质的粘合稳定性。

Dyrk1A-IN-6 (compound 7cc) 是一种EGCG样式的非竞争性DYRK1A抑制剂，常用于改善唐氏综合症模型中的认知障碍。

Delphinidin-3-O-galactoside chloride (Standard) 是 Delphinidin-3-O-galactoside chloride 的标准品。适用于定量分析、质量控制及生化实验等相关研究。Delphinidin-3-O-galactoside chloride has anti-obesity and hypolipidemic effects. Delphinidin-3-O-galactoside (D3G) is a water-soluble anthocyanin with antioxidant activity. D3G is capable of masking the EGCG-induced cytotoxicity and ER stress, presumably through up-regulation of antioxidant enzymes and heat shock proteins.

3-O-(E)-p-coumaroyl tormentic acid may be promising lead compound for developing an effective drug for treatment of leukemia, it induces apoptotic cell death in human leukemia (HL60) via mainly mitochondrial pathway by, at least in part, Topo I inhibition. 3-O-trans-p-coumaroyltormentic acid shows cytotoxicity against four human tumor cell lines (A549, SK-OV-3, SK-MEL-2, and HCT-15) in vitro, the IC50 values of 13.72, 14.29,14.61, 14.04 uM, respectively. 3beta-O-cis-p-Coumaroyltormentic acid, and 3beta-O-trans-p-coumaroyltormentic acid are weakly selective for vancomycin-resistant Enterococcus (VRE) compared with eukaryotic cells, with an MIC of 59.4microg/mL and a 50% inhibitory concentration (IC50) of 72.0microg/mL for monkey kidney epithelial (MA104) cells. A mixture of 3-O-cis-p-coumaroyltormentic acid and 3-O-trans-p-coumaroyltormentic acid shows an inhibitory effect comparable to (-)-epigallocatechin gallate (EGCG) of green tea on the activation of Epstein-Barr virus early antigen (EBV-EA) induced by 12-O-tetradeca--noylphorbol-13-acetate (TPA).

Delphinidin-3-O-galactoside chloride has anti-obesity and hypolipidemic effects. Delphinidin-3-O-galactoside (D3G) is a water-soluble anthocyanin with antioxidant activity. D3G is capable of masking the EGCG-induced cytotoxicity and ER stress, presumably