complement factor d-in-1

Complement factor D-IN-1 is an effective and selective small-molecule reversible factor d inhibitor (IC50s: 0.006 and 0.05 μM in FD Thioesterolytic Fluorescent Assay and a MAC Deposition Assay, respectively).

FD-IN-1(Compound 12)是一种具有口服活性的Factor D(FD)抑制剂（IC50=12nM）,还抑制能够Factor XIa(FXIa)和Tryptase β2，IC50分别为7.7和6.5μM。

N-((Allyloxy)carbonyl)-N-methyl-L-alanine 是一种丙氨酸衍生物。N-((Allyloxy)carbonyl)-N-methyl-L-alanine 可用于合成补体因子 D (complementfactor D) 抑制剂。补体因子 D 抑制剂可用于免疫系统相关疾病的研究。