Powder: -20°C for 3 years | In solvent: -80°C for 1 year
NS1652 是可逆阴离子电导抑制剂,在人和小鼠的红细胞中,可以抑制氯离子通道,IC50值为 1.6 μM。
规格 | 价格/CNY | 货期 | 数量 | |
---|---|---|---|---|
1 mg | ¥ 813 | 现货 | ||
5 mg | ¥ 1,820 | 现货 | ||
10 mg | ¥ 2,890 | 现货 | ||
25 mg | ¥ 4,850 | 现货 | ||
50 mg | ¥ 6,890 | 现货 | ||
100 mg | ¥ 9,330 | 现货 | ||
500 mg | ¥ 18,700 | 现货 |
产品描述 | NS1652 is an anion conductance inhibitor. NS1652 blocks chloride channel has an IC50 of 1.6 μM in human and mouse red blood cells. |
靶点活性 | Cl- channel (human and mouse red blood cells):1.6 μM (IC50) |
体外活性 | NS1652 (20 μM) fully and reversibly inhibits the red cell Cl-conductance. NS1652 effectively inhibits the chloride conductance (IC50, 1.6 μM) in human and mouse red blood cells, but only weakly inhibits VRAC (IC50, 125 μM) in HEK293 cells. NS1652 markedly blocks the NO production (IC50: 3.1 μM in BV2 cells). NS1652 also down-regulates iNOS expression at 3 μM and fully abolishes at 10 μM in BV2 cells. NS1652 (0, 1.0, 3.3, 10, and 20 μM) induces increasing hyperpolarization due to inhibition of the chloride conductance in normal erythrocytes. NS1652 lowers the net KCl loss from deoxygenated sickle cells from about 12 mM cells/h to about 4 mM cells/h [1][2]. |
体内活性 | In mice, NS1652 (50 mg/kg, i.v.) blocks murine erythrocyte Cl- conductance by >90%[2]. |
分子量 | 324.25 |
分子式 | C15H11F3N2O3 |
CAS No. | 1566-81-0 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 4.9 mg/mL (15.11 mM), Sonication is recommended.
可选溶剂 | 浓度 体积 质量 | 1 mg | 5 mg | 10 mg | 25 mg |
DMSO | 1 mM | 3.084 mL | 15.4202 mL | 30.8404 mL | 77.101 mL |
5 mM | 0.6168 mL | 3.084 mL | 6.1681 mL | 15.4202 mL | |
10 mM | 0.3084 mL | 1.542 mL | 3.084 mL | 7.7101 mL |
对于不同动物的给药剂量换算,您也可以参考 更多...
请在以下方框中输入您的动物实验信息后点击计算,可以得到母液配置方法和体内配方的制备方法: 比如您的给药剂量是10 mg/kg,每只动物体重20 g,给药体积100 μL,一共给药动物10 只,您使用的配方为5% DMSO+30% PEG300+5% Tween 80+60% ddH2O。那么您的工作液浓度为2 mg/mL。
母液配置方法:2 mg 药物溶于 50 μL DMSO (母液浓度为 40 mg/mL), 如您需要配置的浓度超过该产品的溶解度,请先与我们联系。
体内配方的制备方法:取 50 μL DMSO 主液,加入 300 μL PEG300, 混匀澄清,再加 50 μL Tween 80,混匀澄清,再加 600 μL ddH2O, 混匀澄清。
您可能有的问题的答案可以在抑制剂处理说明中找到,包括如何准备库存溶液,如何存储产品,以及基于细胞的分析和动物实验需要特别注意的问题。
NS1652 1566-81-0 Membrane transporter/Ion channel Chloride channel Cl? Channels inhibit Inhibitor Chloride Channel NS 1652 NS-1652 inhibitor