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Curcumin

产品编号 T1516 CAS 458-37-7

别名: Indian Saffron, Diferuloylmethane, Natural Yellow 3, Turmeric yellow, 姜黄素

Curcumin 是一种天然酚类，是乙酰转移酶p300/CREB 结合蛋白特异性抑制剂，抑制组蛋白/非组蛋白的乙酰化和组蛋白乙酰转移酶依赖的染色质转录。它对NF-κb 和MAPKs 有抑制作用，具有抗炎、抗氧化、抗增殖和抗血管生成等多种药理作用。

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Curcumin, CAS 458-37-7

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天然产物信息

生物活性

化学信息

存储 & 溶解度

参考文献

相关产品

植物来源	天然产物 > 姜科 > 姜属

产品描述	Curcumin is a phytopolylphenol pigment isolated from the plant Curcuma longa, commonly known as turmeric, with a variety of pharmacologic properties. Curcumin blocks the formation of reactive oxygen species, possesses anti-inflammatory properties as a result of inhibition of cyclooxygenases (COX) and other enzymes involved in inflammation; and disrupts cell signal transduction by various mechanisms including inhibition of protein kinase C. These effects may play a role in the agent's observed antineoplastic properties, which include inhibition of tumor cell proliferation and suppression of chemically induced carcinogenesis and tumor growth in animal models of cancer.
靶点活性	p300 histone acetylatransferase:25 μM
体外活性	Curcumin induces the expression of forkhead box protein O1 (FOXO1) through activation of extracellular signal-regulated kinase 1/2 signaling. Curcumin inhibits cell proliferation, which was associated with upregulation of the cyclin-dependent kinase inhibitors, p27 and p21, and downregulation of cyclin D1[2]. Curcumin induces endoplasmic reticulum (ER) stress and mitochondrial dysfunction as evidenced by up-regulation of CCAAT/enhancer binding protein homologous protein (CHOP), phosphorylation of JNK and down-regulation of SERCA2ATPase, release of cytochrome c, decrease of Bcl-2 and reduction of mitochondrial membrane potential in both AGS and HT-29 cells[3].
体内活性	Chronic treatment with curcumin significantly reverses the CMS-induced behavioral abnormalities in stressed rats. Additionally, curcumin effectively inhibits cytokine gene expression at both the mRNA and the protein level and reduces the activation of NF-κB[4].
细胞实验	1×104 B16-R cells are cultivated as monolayer culture for 12 hr. They were then incubated in 200 μL of RPMI, 10% FBS containing curcumin at final concentrations from 1–100 μM in 96-multiwell plates for 24-48 hr. After these incubations, cells are washed twice in PBS and 500 μl of fresh culture medium containing MTT (0.3 mg/mL) are added for colorimetric assay. (Only for Reference)

别名	Indian Saffron, Diferuloylmethane, Natural Yellow 3, Turmeric yellow, 姜黄素
分子量	368.39
分子式	C21H20O6
CAS No.	458-37-7

存储

Powder: -20°C for 3 years | In solvent: -80°C for 2 years

溶解度

DMSO: 3.7 mg/mL (10 mM)

Ethanol: 1.8 mg/mL (5 mM)

( < 1 mg/mL refers to the product slightly soluble or insoluble )

参考文献

1. Gao S, et al. Food Chem Toxicol. 2013, 59:739-47. 2. Nasiri M, et al. Asian Pac J Cancer Prev. 2013, 14(6):3449-3453. 3. Cao A, et al. Apoptosis. 2013, 18(11):1391-1402. 4. Jiang H, et al. Prog Neuropsychopharmacol Biol Psychiatry. 2013, 47:33-39. 5. Odot J, et al. Int J Cancer. 2004, 111(3):381-387. 6. Lu J, Lu Z, Liu L, et al. Identification of crocin as a new hIAPP amyloid inhibitor via a simple yet highly biospecific screening system[J]. Chemistry & Biodiversity. 2021 7. Zhou H, Ning Y, Zeng G, et al. Curcumin promotes cell cycle arrest and apoptosis of acute myeloid leukemia cells by inactivating AKT[J]. Oncology Reports. 2021, 45(4): 1-1. 8. Sun L, Qian S, Ma Y, et al. Iron Overload Adversely Effects Bone Marrow Haematogenesis via SIRT-SOD2-MROS in a Process Ameliorated by Curcumin[J]. Cellular & Molecular Biology Letters. 2021, 26(1): 1-15. 9. Geng W, Guo X, Zhang L, et al. Resveratrol inhibits proliferation, migration and invasion of multiple myeloma cells via NEAT1-mediated Wnt/β-catenin signaling pathway[J]. Biomedicine & Pharmacotherapy. 2018 Nov;107:484-494. 10. Tian D, Cao L, Li Q, et al. Benzannulated 5, 5-spiroketal sesquiterpenes from the roots of Angelica Pubescens[J]. Bioorganic Chemistry. 2021, 107: 104604.

文献引用

1. Geng W, Guo X, Zhang L, et al. Resveratrol inhibits proliferation, migration and invasion of multiple myeloma cells via NEAT1-mediated Wnt/β-catenin signaling pathway .Resveratrol inhibits proliferation,migration and invasion of multiple myeloma cells via NEAT1-mediated Wnt/β-catenin signaling pathway. Biomedicine & Pharmacotherapy. 2018 Nov;107:484-494. 2. Gou X, Tian D, Wei J, et al. New Drimane Sesquiterpenes and Polyketides from Marine-Derived Fungus Penicillium sp. TW58-16 and Their Anti-Inflammatory and α-Glucosidase Inhibitory Effects. Marine Drugs. 2021, 19(8): 416. 3. Tian D, Cao L, Li Q, et al. Benzannulated 5,5-spiroketal sesquiterpenes from the roots of Angelica Pubescens. Bioorganic Chemistry. 2021, 107: 104604 4. Liu Y P, Xie Z, Guan R Q, et al. Syzysamalactone, an Unusual 11-Carbon δ‑Lactone Derivative from the Fresh Ripe Fruits of Syzygium samarangense (Wax Apple). Journal of Natural Products. 2022 5. Sun L, Qian S, Ma Y, et al. Iron Overload Adversely Effects Bone Marrow Haematogenesis via SIRT-SOD2-MROS in a Process Ameliorated by Curcumin. Cellular & Molecular Biology Letters. 2021, 26(1): 1-15 6. Zhou H, Ning Y, Zeng G, et al. Curcumin promotes cell cycle arrest and apoptosis of acute myeloid leukemia cells by inactivating AKT. Oncology Reports. 2021, 45(4): 1-1. 7. Lu J, Lu Z, Liu L, et al. Identification of crocin as a new hIAPP amyloid inhibitor via a simple yet highly biospecific screening system. Chemistry & Biodiversity. 2021 8. Wang W, Zeng Z, Zhang J, et al.A Systematic Study of Traditional Chinese Medicine for the Treatment of Lung Adenocarcinoma Using a Reverse Network of Key Targets Based on Bioinformatics and Molecular Docking: Curcumin and Trans-Resveratrol as Potential Drug Candidates for Lung Adenocarcinoma.Natural Product Communications.2023, 18(5): 1934578X231169370. 9. Bu H, Wang B, Wu Y, et al.Curcumin strengthens a spontaneous self-protective mechanism-SP1/PRDX6 pathway, against di-n-butyl phthalate-induced testicular ferroptosis damage.Environmental Science and Pollution Research.2023: 1-17.

剂量换算

对于不同动物的给药剂量换算，您也可以参考 更多...

体内实验配液计算器

请在以下方框中输入您的动物实验信息后点击计算，可以得到母液配置方法和体内配方的制备方法：比如您的给药剂量是10 mg/kg，每只动物体重20 g，给药体积100 μL，一共给药动物10 只，您使用的配方为5% DMSO+30% PEG300+5% Tween 80+60% ddH2O。那么您的工作液浓度为2 mg/mL。

母液配置方法：2 mg 药物溶于 50 μL DMSO (母液浓度为 40 mg/mL)，如您需要配置的浓度超过该产品的溶解度，请先与我们联系。

体内配方的制备方法：取 50 μL DMSO 主液，加入 300 μL PEG300，混匀澄清，再加 50 μL Tween 80，混匀澄清，再加 600 μL ddH2O, 混匀澄清。

第一步：请输入动物实验的基本信息

剂量

mg/kg

每只动物体重

给药体积

μL

动物数量

第二步：请输入动物体内配方组成，不同的产品配方组成不同，如有配方需求，可先联系我们提供正确的体内配方。

% DMSO+

% +

% Tween 80+

% ddH₂O

%DMSO+

计算重置

计算结果如下:

工作液浓度: mg/ml;

母液配置方法: mg 药物溶于 μL DMSO (母液浓度为 mg/mL)，如您需要配置的浓度超过该产品的溶解度，请先与我们联系。

体内配方的制备方法：取 μL DMSO 主液，加入 μL PEG300，混匀澄清，再加 μL Tween 80，混匀澄清，再加 μL ddH₂O, 混匀澄清。

备注:

要按顺序从左向右依次添加助溶剂。可配合物理方法，如涡流、超声波或热水浴使之帮助溶解。

计算器

摩尔浓度计算器

稀释计算器

配液计算器

分子量计算器

质量

浓度

容积

分子量

浓度 (起始)

容积 (起始)

浓度 (终)

容积 (终)

溶液体积

质量

配液浓度

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技术支持

您可能有的问题的答案可以在抑制剂处理说明中找到，包括如何准备库存溶液，如何存储产品，以及基于细胞的分析和动物实验需要特别注意的问题。

Keywords

Curcumin 458-37-7 Apoptosis Autophagy Chromatin/Epigenetic Immunology/Inflammation Microbiology/Virology Histone Acetyltransferase Nrf2 Influenza Virus Ferroptosis Epigenetic Reader Domain Mitophagy Indian Saffron Natural Yellow3 HATs Diferuloylmethane Natural Yellow 3 HAT Keap1-Nrf2 inhibit Turmeric yellow 姜黄素 Mitochondrial Autophagy Natural Yellow-3 Inhibitor inhibitor

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Curcumin

存储

溶解度

参考文献

文献引用

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剂量换算

体内实验配液计算器

计算器

输入分子式，点击计算，可计算出产品的分子量。

技术支持

Keywords