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BML-284 (Wnt agonist 1) 是细胞通透性 Wnt 信号激活剂,能够诱导 TCF 依赖的转录活性(EC50>700 nM)。
BML-284 (Wnt agonist 1) 是细胞通透性 Wnt 信号激活剂,能够诱导 TCF 依赖的转录活性(EC50>700 nM)。
规格 | 价格 | 库存 | 数量 |
---|---|---|---|
1 mg | ¥ 237 | In stock | |
5 mg | ¥ 533 | In stock | |
10 mg | ¥ 698 | In stock | |
25 mg | ¥ 1,330 | In stock | |
50 mg | ¥ 2,390 | In stock | |
100 mg | ¥ 3,630 | In stock | |
200 mg | ¥ 5,260 | In stock | |
500 mg | ¥ 8,170 | In stock | |
1 mL x 10 mM (in DMSO) | ¥ 533 | In stock |
产品描述 | BML-284 (Wnt agonist 1) is a potent, selective and , cell-permeable Wnt signaling activator. |
靶点活性 | TCF-dependent transcriptional activity:700 nM (EC50) |
体外活性 | Wnt agonist 1 does not inhibit the activity of GSK-3β, and may be a useful tool in the study of physiological processes that involve the Wnt pathway. [1] |
体内活性 | In a Xenopus model, Wnt agonist 1 (10 μM) mimics the effects of Wnt at the whole-organism level, and affects Xenopus embryonic head specification. [1] |
别名 | Wnt agonist 1 |
分子量 | 350.37 |
分子式 | C19H18N4O3 |
CAS No. | 853220-52-7 |
Smiles | COc1cccc(c1)-c1cc(NCc2ccc3OCOc3c2)nc(N)n1 |
密度 | 1.353 g/cm3 (Predicted) |
存储 | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | |||||||||||||||||||||||||||||||||||
溶解度信息 | H2O: < 1 mg/mL (insoluble or slightly soluble) Ethanol: < 1 mg/mL (insoluble or slightly soluble) DMSO: 75 mg/mL (214.06 mM), Sonication is recommended. ![]() | |||||||||||||||||||||||||||||||||||
溶液配制表 | ||||||||||||||||||||||||||||||||||||
DMSO
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以上为“体内实验配液计算器”的使用方法举例,并不是具体某个化合物的推荐配制方式,请根据您的实验动物和给药方式选择适当的溶解方案。
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