Asymmetric dimethylarginine

Name: Asymmetric dimethylarginine
Brand: TargetMol
SKU: T7682
Price: 475 CNY
Availability: InStock
Rating: 5 (10 reviews)

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很棒

纯度: 99.62%

货号 T7682Cas号 30315-93-6

Asymmetric dimethylarginine 是内源性一氧化氮合成酶抑制剂，可以作为内皮功能障碍的标志。

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Asymmetric dimethylarginine

一键复制产品信息

很棒

纯度: 99.62%

货号 T7682Cas号 30315-93-6

Asymmetric dimethylarginine 是内源性一氧化氮合成酶抑制剂，可以作为内皮功能障碍的标志。

规格	价格	库存
5 mg	¥ 475	现货
10 mg	¥ 712	现货
25 mg	¥ 1,498	现货
50 mg	¥ 2,257	现货
100 mg	¥ 3,424	现货

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产品介绍

Asymmetric dimethylarginine AI Summary

Asymmetric dimethylarginine exhibits a broad spectrum of bioactivity with potential implications in modulating various biological pathways and enzymatic functions. Notably, it affects dimethylarginine dimethylaminohydrolase 1 (DDAH1) activity across different species and mutants, influencing enzyme efficiency as indicated by Kcat/Km values. It exerts dual roles in the NFkB signaling pathway, acting both as an agonist and antagonist with a potency of 28183.8 nM. Additionally, it serves as an agonist for the Thyroid Stimulating Hormone Receptor, an inhibitor and substrate of Cytochrome P450 2C19, and inhibits several other enzymes including Histone Lysine Methyltransferase G9a, Mammalian Selenoprotein Thioredoxin Reductase 1 (TrxR1), and Human Flap endonuclease 1 (FEN1). It also enhances Arylsulfatase A (ASA1) activity and demonstrates antiviral activity against SARS-CoV-2 by inhibiting cytotoxicity in Caco-2 and VERO-6 cells. Furthermore, Asymmetric dimethylarginine exhibits moderate inhibition against the SARS-CoV-2 3CL-Pro protease and influences human HDAC6 enzyme activity, highlighting its multifaceted bioactivity and potential therapeutic applications..

Note: Summary generated by AI. Data source: ChEMBL

生物活性

产品描述	Asymmetric dimethylarginine is an endogenous inhibitor of nitric oxide synthase (NOS)

化学信息

分子量	202.25
分子式	C₈H₁₈N₄O₂
CAS No.	30315-93-6
Smiles	CN(C)N=CNCCC[C@H](N)C(O)=O
密度	1.23 g/cm3 (Predicted)
颜色	White
物理性状	Solid

储存&溶解度

存储

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

溶解度信息

H2O: 100 mg/mL (494.44 mM), when pH is adjusted to 2-3 with HCl.

DMSO: 26.25 mg/mL (129.79 mM), Sonication is recommended.

溶液配制表

DMSO/H2O

	1mg	5mg	10mg	50mg
1 mM	4.9444 mL	24.7219 mL	49.4438 mL	247.2188 mL
5 mM	0.9889 mL	4.9444 mL	9.8888 mL	49.4438 mL
10 mM	0.4944 mL	2.4722 mL	4.9444 mL	24.7219 mL
20 mM	0.2472 mL	1.2361 mL	2.4722 mL	12.3609 mL
50 mM	0.0989 mL	0.4944 mL	0.9889 mL	4.9444 mL
100 mM	0.0494 mL	0.2472 mL	0.4944 mL	2.4722 mL