eif4e-eif4g

ATPγS tetralithium salt 是 RNA 刺激的核苷酸水解和 eIF4A 的 RNA 解旋活性的良好底物。

4E2RCat 是一种 eIF4E-eIF4G 相互作用的抑制剂，IC50为13.5 μM。

4EGI-1 是一种竞争性 eIF4E eIF4 g 相互作用抑制剂，与 eIF4E 结合，Kd 值为 25 μM。

(Z)-4EGI-1 is the Z-isomer of 4EGI-1 and is an inhibitor of eIF4E eIF4G interaction and of translation initiation. (Z)-4EGI-1 effectively binds to eIF4E with an IC50 of 43.5 μM and a Kd value of 8.74 μM. (Z)-4EGI-1 has anticancer activity[1][2]. [1]. Khuloud Takrouri, et al. Structure-activity Relationship Study of 4EGI-1, Small Molecule eIF4E eIF4G Protein-Protein Interaction Inhibitors. Eur J Med Chem. 2014 Apr 22;77:361-77. [2]. Poornachandran Mahalingam, et al. Synthesis of Rigidified eIF4E eIF4G inhibitor-1 (4EGI-1) Mimetic and Their in Vitro Characterization as Inhibitors of Protein-Protein Interaction. J Med Chem. 2014 Jun 26;57(12):5094-111.