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(2S,3R,4S)-4-Hydroxyisoleucine

Name: (2S,3R,4S)-4-Hydroxyisoleucine
Brand: TargetMol
SKU: T2P2919
Price: 132 CNY
Availability: InStock
Rating: 5 (10 reviews)

Synonyms: Hydroxyisoleucine, (4S)4-羟基异亮氨酸, (4S)-4-Hydroxy-L-isoleucine

货号 T2P2919Cas号 55399-93-4 一键复制产品信息纯度: 99.95%

很棒

(2S,3R,4S)-4-Hydroxyisoleucine (Hydroxyisoleucine) 是分离自胡芦巴中的一种可口服的有效成分，具有抗糖尿病、抗糖尿病肾病的作用。

(2S,3R,4S)-4-Hydroxyisoleucine

一键复制产品信息

很棒

纯度: 99.95%

货号 T2P2919Cas号 55399-93-4

别名 Hydroxyisoleucine, (4S)4-羟基异亮氨酸, (4S)-4-Hydroxy-L-isoleucine

(2S,3R,4S)-4-Hydroxyisoleucine (Hydroxyisoleucine) 是分离自胡芦巴中的一种可口服的有效成分，具有抗糖尿病、抗糖尿病肾病的作用。

规格	价格	库存
200 mg	¥ 132	现货
500 mg	¥ 228	现货
1 g	¥ 372	现货

库存状态实时更新，以官网显示为准，现货产品可直接加购物车下单

大包装 & 定制

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TargetMol的所有产品仅用作科学研究或药证申报，不能被用于人体，我们不向个人提供产品和服务。请您遵守承诺用途，不得违反法律法规规定用于任何其他用途。

凭借在化合物合成方面的丰富经验，我们可以根据您的研究需求为该产品提供快速定制合成服务。

实验操作小课堂

常见问题解答

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纯度: 99.95%

颜色: 白色

性状: Solid

资源下载: COA HNMR LCMS产品操作手册

产品介绍

(2S,3R,4S)-4-Hydroxyisoleucine AI Summary

(2S,3R,4S)-4-Hydroxyisoleucine exhibits multifaceted bioactivity. In dyslipidemic male Syrian hamsters, it lowers plasma triglyceride levels by 33.0%, total cholesterol by 22.0%, free fatty acids by 14.0%, and glycerol by 4.9% at a dosage of 50 mg/kg orally, while increasing HDL-cholesterol by 8.7% and enhancing the HDL-cholesterol to total cholesterol ratio by 39.0%. In Sprague-Dawley rat pancreas, it significantly boosts insulin secretion, ranging from 45.0 pg/hr to 100.0 pg/hr per Langerhans islet. Furthermore, it shows chemical stability at pH 1 with values of 10.0% at 1 hour, 32.0% at 4 hours, and 73.0% at 20 hours. For antiviral activity, (2S,3R,4S)-4-Hydroxyisoleucine inhibits SARS-CoV-2 induced cytotoxicity in Caco-2 cells with an inhibition rate of 11.94% at 10 µM after 48 hours and also shows activity against SARS-CoV-2 in VERO-6 cells with inhibition ranging from 0.0% to 0.19% in different assays. Additionally, it inhibits the SARS-CoV-2 3CL-Pro protease, with inhibition percentages of 26.4% and 0.1154% at a 20 µM concentration in different assays. The compound also inhibits human HDAC6 enzyme activity, showing -7.36% inhibition with a commercial peptide substrate and 21.36% inhibition with a custom peptide substrate, indicating potential bioactivity relevant to HDAC6 enzyme inhibition and its associated biological processes and diseases..

Note: Summary generated by AI. Data source: ChEMBL

生物活性

产品描述

(2S,3R,4S)-4-Hydroxyisoleucine (Hydroxyisoleucine) from fenugreek (Trigonella foenum-graecum) seeds is a potential insulinotropic (anti-diabetic) and anti-obesity amino acid. HIL stimulates glucose-dependent insulin secretion from pancreatic cells. HIL activates insulin receptor substrate-associated phosphoinositide 3 (PI3) kinase activity. HIL reduces plasma levels of triglycerides, free fatty acids and cholesterol.

别名

Hydroxyisoleucine, (4S)4-羟基异亮氨酸, (4S)-4-Hydroxy-L-isoleucine

化学信息

分子量	147.17
分子式	C₆H₁₃NO₃
CAS No.	55399-93-4
Smiles	[C@@H]([C@@H](C(O)=O)N)([C@H](C)O)C
密度	1.181 g/cm3 at 20℃

储存&溶解度

存储

Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature.

实际储存温度请以COA为准

溶解度信息

DMSO: < 1 mg/mL (insoluble or slightly soluble)

H2O: 110 mg/mL (747.43 mM), Sonication is recommended.

溶液配制表

H2O

	1mg	5mg	10mg	50mg
1 mM	6.7949 mL	33.9743 mL	67.9486 mL	339.7432 mL
5 mM	1.3590 mL	6.7949 mL	13.5897 mL	67.9486 mL
10 mM	0.6795 mL	3.3974 mL	6.7949 mL	33.9743 mL
20 mM	0.3397 mL	1.6987 mL	3.3974 mL	16.9872 mL
50 mM	0.1359 mL	0.6795 mL	1.3590 mL	6.7949 mL
100 mM	0.0679 mL	0.3397 mL	0.6795 mL	3.3974 mL

该溶液配制表仅适用于固体产品。对于液体产品，请根据标明的浓度或密度计算稀释方案。

计算器

摩尔浓度计算器
稀释计算器
配液计算器
分子量计算器

体内实验配液计算器

请在以下方框中输入您的动物实验信息后点击计算，可以得到母液配置方法和体内配方的制备方法：

比如您的给药剂量是10 mg/kg，每只动物体重20 g，给药体积100 μL，一共给药动物10只，您使用的配方为 10% DMSO + 40% PEG300 + 5% Tween 80 + 45% Saline / PBS / ddH₂O，那么您的工作液浓度为2 mg/mL。

母液配置方法：2 mg 药物溶于 100 μL DMSO （母液浓度为 20 mg/mL ）, 如您需要配置的浓度超过该产品的溶解度，请先与我们联系。

体内配方的制备方法： 取 100 μL DMSO 母液，添加 400 μL PEG300 混匀澄清，再加 50 μL Tween 80, 混匀澄清, 再加 450 μL Saline / PBS / ddH₂O 混匀澄清

以上为“体内实验配液计算器”的使用方法举例，并不是具体某个化合物的推荐配制方式，请根据您的实验动物和给药方式选择适当的溶解方案。

方案所需的各类助溶剂如： DMSO， PEG300， PEG400， Tween 80， SBE-β-CD，玉米油等，均可在TargetMol网站点击购买。

剂量转换

对于不同动物的给药剂量换算，您也可以参考更多

关键词

PI3K Inhibitor inhibit 4-Hydroxy-L-isoleucine 4-Hydroxyisoleucine (2S,3R,4S)4Hydroxyisoleucine (2S,3R,4S) 4 Hydroxyisoleucine

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(2S,3R,4S)-4-Hydroxyisoleucine

(2S,3R,4S)-4-Hydroxyisoleucine