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cGAS

Cyclic GMP-AMP synthase (cGAS, cGAMP synthase), belonging to the nucleotidyltransferase family, is a cytosolic DNA sensor that activates a type-I interferon response. It is part of the cGAS-STING DNA sensing pathway. It binds to microbial DNA as well as self DNA that invades the cytoplasm, and catalyzes cGAMP synthesis. cGAMP then functions as a second messenger that binds to and activates the endoplasmic reticulum protein STING to trigger type-I IFNs production. Mice lacking cGAS are more vulnerable to lethal infection by DNA viruses and RNA viruses. In addition, cGAS has been shown to be an innate immune sensor of retroviruses including HIV. The human gene encoding cGAS is MB21D1 on chromosome 6.

Cat. No.	Product Name	CAS No.	Purity
T5486	RU.521 化合物RU320521	2262452-06-0	99.82%
T5486	RU320521 是选择性的环状 GMP-AMP 合成酶 (cGAS) 抑制剂，抑制 cGAS 介导的干扰素上调。它也抑制dsDNA 激活受体的活性，IC50为 700 nM。它可降低来自 Aicardi-Goutières 综合征小鼠模型的巨噬细胞中干扰素的组成型表达。
T11673	IRAK4-IN-4 化合物IRAK4-IN-4	1850276-58-2	99.13%
T11673	IRAK4-IN-4 是白介素-1 受体相关激酶抑制剂，IC50为 2.8 nM。它还抑制环 GMP-AM 合酶，IC50为 2.1 nM。详细信息请参考专利文献 CN107163044A 中的化合物 15。
T12432	PF-06928215 化合物PF-06928215	2378173-15-8	98.73%
T12432	PF-06928215 是高亲和力cGAS抑制剂，IC50为 4.9 μΜ，亲和力Kd值为 0.2 μΜ。
T9213	G140 化合物G140	2369751-07-3	98.16%
T9213	G140 是选择性环状GMP-AMP合酶抑制剂，具有抗炎活性，对 h-cGAS 和 m-cGAS 的IC50值分别为 14.0 和 442 nM。
T11344	G150 化合物G150	2369751-30-2	97.39%
T11344	G150 是高选择性h-cGAS抑制剂，IC50值为 10.2 nM，用于抑制 dsDNA 引发的干扰素表达。