MALT

MALT1 is a paracaspase, which is related to the caspase (cysteine-aspartic proteases) family of proteases but cleaves after Arg residues instead of Asp. MALT1 cleavage activity is linked to the pathogenesis of activated B cell-like diffuse large B cell lymphoma (ABC-DLBCL), a chemoresistant form of DLBCL. MALT1 is a unique paracaspase protein that transduces aberrant oncogenic signaling in ABC-DLBCL. MALT1 represents a potentially important therapeutic target for ABC-DLBCL and MALT lymphoma. MALT1 small molecule inhibitors might be useful chemical tools for studying MALT1 biology and treating MALT1-addicted tumors.

Cat. No.	Product Name	CAS No.	Purity
T2350	MALT1 inhibitor MI-2 化合物MI 2 (MALT1 inhibitor)	1047953-91-2	99.87%
MI 2 (MALT1 inhibitor) 是一种MALT1抑制剂 (IC50=5.84 μM)，对动物无毒性。它能够直接与 MALT1 结合，不可逆地抑制蛋白酶功能，并伴有 NF-κB 报告子活性抑制、c-REL 核定位抑制和 NF-κB 靶基因下调。
T9216	MLT-943 化合物MLT943	1832576-04-1	99.82%
ML943 是选择性的、口服活性的MALT1 protease抑制剂。它可抑制 PBMC 或全血中 IL-2 的分泌，PBMC 中抑制的IC50值为 0.07~0.09 μM，全血中抑制的IC50值为 0.6~0.8 μM)。它具有抗炎作用，可用于研究 FcgR 介导的炎症。
T36670	JNJ-67856633 化合物JNJ-67856633	2230273-76-2	98%
JNJ-67856633 是口服有效的、选择性的、变构性的MALT1 protease抑制剂。在某些情况下，JNJ-67856633可以导致肿瘤停滞。
T16040	Mepazine 甲哌啶嗪	60-89-9	98%
Mepazine 是一种有效的特异性 MALT1 抑制剂。 Mepazine 抑制 GSTMALT1 全长和 GSTMALT1 325-760，IC50 为 0.83 μM 和 0.42 μM。 Mepazine 增强细胞凋亡并影响细胞活力。
T16077	MIR96-IN-1 化合物 T16077	1311982-88-3	98%
MIR96-IN-1 selectively inhibits biogenesis of microRNA-96, upregulating a protein target (FOXO1) and inducing apoptosis in cancer cells.
T16132	MRE3008F20 化合物 T16132	252979-43-4	98%
MRE3008F20 is a highly effective and selective antagonist of adenosine A3 receptor (AA3R). MRE3008F20 also inhibits agonist-induced cAMP elevation in resting T l...

Cat. No.

Product Name

CAS No.

Purity

Chemical Structure

T2350

MALT1 inhibitor MI-2

化合物MI 2 (MALT1 inhibitor)

1047953-91-2

99.87%

MI 2 (MALT1 inhibitor) 是一种MALT1抑制剂 (IC50=5.84 μM)，对动物无毒性。它能够直接与 MALT1 结合，不可逆地抑制蛋白酶功能，并伴有 NF-κB 报告子活性抑制、c-REL 核定位抑制和 NF-κB 靶基因下调。

T9216

MLT-943

化合物MLT943

1832576-04-1

99.82%

ML943 是选择性的、口服活性的MALT1 protease抑制剂。它可抑制 PBMC 或全血中 IL-2 的分泌，PBMC 中抑制的IC50值为 0.07~0.09 μM，全血中抑制的IC50值为 0.6~0.8 μM)。它具有抗炎作用，可用于研究 FcgR 介导的炎症。

T36670

JNJ-67856633

化合物JNJ-67856633

2230273-76-2

98%

JNJ-67856633 是口服有效的、选择性的、变构性的MALT1 protease抑制剂。在某些情况下，JNJ-67856633可以导致肿瘤停滞。

T16040

Mepazine

甲哌啶嗪

60-89-9

98%

Mepazine 是一种有效的特异性 MALT1 抑制剂。 Mepazine 抑制 GSTMALT1 全长和 GSTMALT1 325-760，IC50 为 0.83 μM 和 0.42 μM。 Mepazine 增强细胞凋亡并影响细胞活力。

T16077

MIR96-IN-1

化合物 T16077

1311982-88-3

98%

MIR96-IN-1 selectively inhibits biogenesis of microRNA-96, upregulating a protein target (FOXO1) and inducing apoptosis in cancer cells.

T16132

MRE3008F20

化合物 T16132

252979-43-4

98%

MRE3008F20 is a highly effective and selective antagonist of adenosine A3 receptor (AA3R). MRE3008F20 also inhibits agonist-induced cAMP elevation in resting T l...