vdac

Erastin 是一种作用于线粒体 VDAC 的铁死亡激活剂，具有 ROS 和铁依赖性。Erastin 具有抗肿瘤活性，选择性作用于 RAS 致癌突变的肿瘤细胞。

Tuvatexib 是一种小分子VDAC/HK2双调节剂。

NSC 15364 (1,3-Bis(4-aminophenyl)urea) 是一种 VDAC1寡聚化和细胞凋亡抑制剂。

HexokinaseIIVDACbinding domain peptide (Hxk2VBD peptide) 是一种可渗透细胞的己糖激酶 IIVDAC结合域，能够抑制己糖激酶 2 (HXK2) 的线粒体定位，并对神经营养因子导向的轴突生长产生抑制作用。

VBIT-4 是一种电压依赖性阴离子通道 1 (VDAC1) 寡聚化抑制剂 (Kd=17 μM)。VBIT-4 可以预防线粒体功能障碍和细胞凋亡，并恢复细胞能量和代谢。VBIT-4 可用于治疗神经退行性疾病和心血管疾病。

VBIT-12 是一种有效的 VDAC1 抑制剂。

WEHI-9625 is a tricyclic sulfone small molecule apoptosis inhibitor (EC50: 69 nM).

DIDS, an anion exchange inhibitor, acts by blocking reversibly and later irreversibly, exchangers such as chloride-bicarbonate exchanger. It is also a RAD51 inhibitor.

VBIT-3 is a voltage-dependent anion channel 1 (VDAC1) oligomerization inhibitor (Kd: 31.3 μM). VBIT-3 also is an apoptosis inhibitor, can be used for therapeutic purposes in apoptosis-associated disorders (such as neurodegenerative and cardiovascular diseases).

AKOS-22 is a potent mitochondrial protein VDAC1 (voltage-dependent anion channel 1) inhibitor (Kd=15.4 μM). AKOS-22 protects against mitochondrial dysfunction[1]. AKOS-22 interacts with VDAC1 and inhibiting both VDAC1 oligomerization and apoptosis.

RSL3 (RSL3 1S) 是一种 GPX4 的抑制剂，抑制阻断 GSH 合成的 system xc- (IC50=100 nM)。RSL3 是一种不依赖 VDAC 的铁死亡激活剂，对携带致癌 RAS 的肿瘤细胞具有选择性。