tnp

TNP (IP3K Inhibitor) 是细胞渗透性的IP6K1和IP3K 的抑制剂， 其对IP6K1 和IP3K 的IC50值分别为 0.55 μM 和 10.2 μM。TNP 与两种酶的ATP 结合位点结合。

TNP-470 is a methionine aminopeptidase-2 inhibitor. TNP-470 is also an angiogenesis inhibitor.

Tnp 351 is a novel antifolate drug being assessed for chemotherapy of lung cancer.

P2X receptor antagonist

PALATINOSE (TNP-470) 是一种天然存在的二糖，由α-1,6-连接的葡萄糖和果糖组成。PALATINOSE 对肝脏代谢功能具有有益的影响，因此可能是蔗糖甜味剂的良好替代品。

TTNPB (Ro 13-7410,AGN-191183) 是一种RAR 激动剂。在使用人RARs 进行竞争性结合实验中，作用于RARα，RARβ和RARγ，IC50分别为 5.1 nM，4.5 nM 和 9.3 nM。

BTNPO is a unimolecular two-photon fluorescent probe.

CBR-2092 is a DNA-directed RNA polymerase and DNA topoisomerase inhibitor. CBR-2092 exhibited rifampin-like potency as an inhibitor of RNA polymerase, was an equipotent (balanced) inhibitor of DNA gyrase and DNA topoisomerase IV, and retained activity against a prevalent quinolone-resistant variant. Studies of mutant strains that exhibited reduced susceptibility to CBR-2092 further substantiated RNA polymerase as the primary cellular target of CBR-2092, with DNA gyrase and DNA topoisomerase IV being secondary and tertiary targets, respectively, in strains exhibiting preexisting rifampin resistance.

A-849519 is a reversible inhibitor of MetAP2 that has demonstrated anti-angiogenesis and anticancer activity in a number of in vitro and in vivo models. In this study, we evaluated the anticancer activity of A-849519 in a modified Dunning model of androgen-independent prostate cancer and compared its efficacy with TNP-470, an established MetAP2 inhibitor.

Rifasutenizol (TNP-2198)为一种有效的口服生物利用度高的双靶向抗菌剂，对微需氧菌和厌氧菌病原体展现出强大的活性。

8-Mercaptoguanosine 是一种免疫佐剂，能够影响 T 细胞非依赖型抗原 TNP-Ficoll 的体内抗体反应。它可以增强 IgG1、IgG2 和 IgG3 的抗体反应，而对 IgM 抗体反应没有影响。此外，8-Mercaptoguanosine 还能增强对极弱抗原如肺炎球菌多糖的抗体反应，并恢复对 TNP-Ficoll 无反应的免疫缺陷 xid 小鼠的抗体反应。

Fumagillol 是有效的血管生成抑制剂 TNP-470 和 fumagillin 的直接前体。Fumagillin 作为一种抗菌药物，是选择性有效血管生成抑制剂。