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Pleiotrophin/PTN Protein, Human, Recombinant

产品编号 TMPY-03361

别名: HBNF, HBGF8, pleiotrophin, HARP, NEGF1

Pleiotrophin/PTN Protein, Human, Recombinant is expressed in Baculovirus insect cells. The predicted molecular weight is 15.3 kDa and the accession number is A0A024R778.

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Pleiotrophin/PTN Protein, Human, Recombinant

规格	价格/CNY		货期	数量
20 μg	￥ 1,750		5日内发货
100 μg	￥ 4,420		5日内发货
1 mg	￥ 28,800		5日内发货

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生物活性

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参考文献

生物活性	Measured by its binding ability in a functional ELISA. Immobilized human PTN at 10 μg/ml (100 μl/well) can bind rat SDC1-Fc , The EC50 of rat SDC1-Fc is 0.35-0.81 μg/ml.
产品描述	Pleiotrophin/PTN Protein, Human, Recombinant is expressed in Baculovirus insect cells. The predicted molecular weight is 15.3 kDa and the accession number is A0A024R778.

种属	Human
表达系统	Baculovirus Insect Cells
标签	Tag Free
蛋白编号	A0A024R778
别名	HBNF, HBGF8, pleiotrophin, HARP, NEGF1
蛋白构建	mature form of Human PTN (NP_002816.1) (Met1-Asp168)
蛋白纯度	> 90 % as determined by SDS-PAGE
分子量	15.3 kDa (predicted)

内毒素	< 1.0 EU/μg of the protein as determined by the LAL method.
缓冲液	Lyophilized from a solution filtered through a 0.22 μm filter, containing 20 mM Tris, 1M NaCl, pH 8.0.Typically, a mixture containing 5% to 8% trehalose, mannitol, and 0.01% Tween 80 is incorporated as a protective agent before lyophilization.
复溶方法	A Certificate of Analysis (CoA) containing reconstitution instructions is included with the products. Please refer to the CoA for detailed information.
存储	It is recommended to store recombinant proteins at -20°C to -80°C for future use. Lyophilized powders can be stably stored for over 12 months, while liquid products can be stored for 6-12 months at-80℃. For reconstituted proteinsolutions, the solution can be stored at -20°c to -80'c for at least 3 months. Please avoid multiple freeze-thaw cycles and store products in aliquots.
运输方式	In general, Lyophilized powders are shipping with blue ice.
研究背景	HB-GAM belongs to the pleiotrophin family. During embryonic and early postnatal development, HB-GAM is expressed in the central and peripheral nervous system and also in several non-neural tissues, notably lung, kidney, gut and bone. While in the adult central nervous system, it is expressed in an activity-dependent manner in the hippocampus where it can suppress long term potentiation induction. HB-GAM has a low expression in other areas of the adult brain, but it can be induced by ischemic insults, or targeted neuronal damage in the entorhinal cortex or in the substantia nigra pars compacta. It is structurally related to midkine and retinoic acid induced heparin-binding protein and has a high affinity for heparin. HB-GAM binds anaplastic lymphoma kinase (ALK) which induces MAPK pathway activation, an important step in the anti-apoptotic signaling of PTN and regulation of cell proliferation. It also functions as a secreted growth factor and induces neurite outgrowth and which is mitogenic for fibroblasts, epithelial, and endothelial cells.

参考文献

1. Vanderwinden JM,et al. (1992) Cellular distribution of the new growth factor pleiotrophin (HB-GAM) mRNA in developing and adult rat tissues. Anat Embryol. 186(4):387-406. 2. Lauri SE,et al. (1996) Activity-induced enhancement of HB-GAM expression in rat hippocampal slices. Neuroreport. 7(10):1670-4. 3. Pavlov I,et al. (2002) Role of heparin-binding growth-associated molecule (HB-GAM) in hippocampal LTP and spatial learning revealed by studies on overexpressing and knockout mice. Mol Cell Neurosci. 20(2):330-42.

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Keywords

Pleiotrophin/PTN Protein, Human, Recombinant HBNF HBGF8 HBGF 8 pleiotrophin HARP NEGF 1 NEGF1 NEGF-1 HBGF-8 recombinant recombinant-proteins proteins protein

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