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Pleiotrophin/PTN Protein, Mouse, Recombinant (hFc)

Pleiotrophin/PTN Protein, Mouse, Recombinant (hFc)

产品编号 TMPY-02850
别名: Osf-1, HB-GAM, HBGF-8, HBBN, pleiotrophin, OSF, HARP, HBNF, Osf1

Pleiotrophin/PTN Protein, Mouse, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 43.7 kDa and the accession number is P63089.

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Pleiotrophin/PTN Protein, Mouse, Recombinant (hFc)
规格 价格/CNY 货期 数量
100 μg ¥ 2,440 5日内发货
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产品目录号及名称: Pleiotrophin/PTN Protein, Mouse, Recombinant (hFc) (TMPY-02850)
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生物活性 Testing in progress
产品描述 Pleiotrophin/PTN Protein, Mouse, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 43.7 kDa and the accession number is P63089.
种属 Mouse
表达系统 HEK293 Cells
标签 N-hFc
蛋白编号 P63089
别名 Osf-1, HB-GAM, HBGF-8, HBBN, pleiotrophin, OSF, HARP, HBNF, Osf1
蛋白构建 The Mouse PTN (P63089) (Gly 33-Asp 168) was fused with the Fc region of Human IgG1 at the N-terminus.
蛋白纯度 > 85 % as determined by SDS-PAGE
分子量 43.7 kDa (predicted)
内毒素 < 1.0 EU/μg of the protein as determined by the LAL method.
缓冲液 Lyophilized from a solution filtered through a 0.22 μm filter, containing PBS, pH 7.4. Typically, a mixture containing 5% to 8% trehalose, mannitol, and 0.01% Tween 80 is incorporated as a protective agent before lyophilization.
复溶方法 A Certificate of Analysis (CoA) containing reconstitution instructions is included with the products. Please refer to the CoA for detailed information.
存储

It is recommended to store recombinant proteins at -20°C to -80°C for future use. Lyophilized powders can be stably stored for over 12 months, while liquid products can be stored for 6-12 months at-80℃. For reconstituted proteinsolutions, the solution can be stored at -20°c to -80'c for at least 3 months. Please avoid multiple freeze-thaw cycles and store products in aliquots.

运输方式

In general, Lyophilized powders are shipping with blue ice.

研究背景 HB-GAM belongs to the pleiotrophin family. During embryonic and early postnatal development, HB-GAM is expressed in the central and peripheral nervous system and also in several non-neural tissues, notably lung, kidney, gut and bone. While in the adult central nervous system, it is expressed in an activity-dependent manner in the hippocampus where it can suppress long term potentiation induction. HB-GAM has a low expression in other areas of the adult brain, but it can be induced by ischemic insults, or targeted neuronal damage in the entorhinal cortex or in the substantia nigra pars compacta. It is structurally related to midkine and retinoic acid induced heparin-binding protein and has a high affinity for heparin. HB-GAM binds anaplastic lymphoma kinase (ALK) which induces MAPK pathway activation, an important step in the anti-apoptotic signaling of PTN and regulation of cell proliferation. It also functions as a secreted growth factor and induces neurite outgrowth and which is mitogenic for fibroblasts, epithelial, and endothelial cells.

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Keywords

Pleiotrophin/PTN Protein, Mouse, Recombinant (hFc) Osf-1 HBGF 8 HB-GAM HBGF-8 HBBN pleiotrophin OSF HARP HBNF Osf1 HBGF8 recombinant recombinant-proteins proteins protein

 

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