neuronal nicotinic receptor

Rivanicline oxalate is an agonist of neuronal nicotinic receptor, showing high selectivity for the α4β2 subtype (Ki=26 nM).

Nelonicline is a selective agonist of neuronal nicotinic receptors.

TMPH 是一种 nAChR 抑制剂，可抑制缺乏 α5、α6 或 β3 亚基的 nAChR。 TMPH 可用于关于 nAChR 功能障碍或神经系统疾病的研究。

Rivanicline 2HCl 是一种选择性神经元烟碱受体(neuronal nicotinic receptor) 的抑制剂，对α4β2 亚型的亲和力较高。

SIB-1553A hydrochloride 是一种可口服且具有选择性的烟碱乙酰胆碱受体激动剂，还是一种选择性神经元 nAChR 配体。SIB-1553A hydrochloride 可增强认知，可用于研究阿尔茨海默病和认知障碍。

AZD 3043 (THRX 918661)是 γ-氨基丁酸 A 型受体的变构调节剂，是一种新型镇静催眠剂，是一种潜在的短效麻醉剂，在大鼠中产生催眠和脑电图抑制。AZD 3043可增强γ-氨基丁酸A型受体，抑制神经元烟碱乙酰胆碱受体。

Carbachol (Carbamoylcholine chloride) 用来研究 nAChR 和 mAchR 的介导的反应, 包括平滑肌收缩, 肠运动, 与神经信号。Carbachol 是乙酰胆碱类似物, 激活乙酰胆碱受体 (AChR), Carbachol 是 nAChR 和mAchR 受体激动剂, 针对不同的受体, Ki 值为10到10,000 nM。

Methyllycaconitine citrate (MLA) 是一种可穿过血脑屏障的 α7 神经元烟碱乙酰胆碱受体（α7nAChR）拮抗剂，可用于研究神经系统疾病。

A 582941 HCl (848591-90-2(free base)) 是一种具有广谱认知增强特性的 alpha7 神经元烟碱受体激动剂。

Lobeline hydrochloride (α-Lobeline hydrochloride) 是一种烟碱样受体激动剂，是神经元烟碱受体α3β2和α4β2拮抗剂。

Rivanicline hemioxalate (RJR-2403 hemioxalate; (E)-Metanicotine hemioxalate) 是一种神经元烟碱受体 (neuronal nicotinic receptor) 激动剂，对 α4β2 亚型有高度选择性(Ki= 26 nM)，比对于 α7 受体的选择性高1000倍(Ki=3.6 μM)。

Rivanicline is a neuronal nicotinic receptor agonist, showing high selectivity for the α4β2 subtype (Ki=26 nM). It show > 1,000 fold selectivity than α7 receptors(Ki= 36000 nM and IC50 : 26 nM).

Pozanicline reverses nicotine withdrawal-induced cognitive deficits, may be an effective component of novel therapeutic strategies for nicotine addiction. Pozanicline selectively activate neuronal nicotinic acetylcholine receptor (nAChR) subtypes, is a no

(S)-PNU-282987 is the absolute stereochemistry form of PNU-282987. PNU 282987, a potent agonist of α7-containing neuronal nicotinic acetylcholine receptors (nAChRs) with Ki of 26 nM for the rat receptor, has negligible activity against α1β1γδ and α3β4 nAC

neuronal nicotinic ACh receptor partial agonist

DMAB-anabaseine dihydrochloride (N,N-dimethyl-4-[(E)-(6-pyridin-3-yl-3,4-dihydro-2H-pyridin-5-ylidene)methyl]aniline;dihydrochloride) 是一种含有 α7 的神经元烟碱受体部分激动剂和 α4β2 和其他烟碱受体的拮抗剂。

neuronal nicotinic ACh receptor agonist

A-424274 is a positive allosteric modulator of α4β2 neuronal nicotinic receptor.

High affinity and subtype selective α6β2 and α4β2 partial agonist (Ki values are 12 and 26nM for rat α6β2 and α4β2 receptors respectively). Has low affinity for α3β4 and α7 receptors (Ki values are 4.8 and 13 μM for human α3β4 and rat α7 receptors respectively). Stimulates dopamine release from striatal slices in vitro. Attenuates nicotine-induced self-administration and conditional place preference in rats. Sala et al (2013) CC4, a dimer of cytisine, is a selective partial agonist at α4β2/α6β2 nAChR with improved selectivity for tobacco smoking c Br.J.Pharmacol. 168 835 PMID:22957729 |Riganti et al (2005) Long-term exposure to the new nicotinic antagonist 1,2-bisN-cytisinylethane upregulates nicotinic receptor subtypes of SH-SY5Y human neuroblastoma cells. Br.J.Pharmacol. 146 1096 PMID:16273122 |Carbonnelle et al (2003) Nitrogen substitution modifies the activity of cytisine on neuronal nicotinic receptor subtypes. Eur.J.Pharmacol. 471 85 PMID:12818695

ABT-107, a selective α7 neuronal nicotinic receptor agonist, demonstrates neuroprotective effects against nigrostriatal damage in rats with unilateral 6-hydroxydopamine lesions.

SUVN-911 是高选择性的，大脑通透性的和口服有效的神经元烟碱乙酰胆碱 α4β2 受体拮抗剂，Ki 为 1.5 nM。SUVN-911显示出抗抑郁作用。

Neuronal nicotinic receptor antagonist