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Lobeline hydrochloride

Name: Lobeline hydrochloride
Brand: TargetMol
SKU: T0268
Price: 127 CNY
Availability: InStock
Rating: 5 (10 reviews)

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很棒

纯度: 99.43%

货号 T0268Cas号 134-63-4

别名 盐酸洛贝林, α-Lobeline hydrochloride, L-Lobeline hydrochloride

Lobeline hydrochloride (α-Lobeline hydrochloride) 是一种烟碱样受体激动剂，是神经元烟碱受体α3β2和α4β2拮抗剂。

Lobeline hydrochloride

一键复制产品信息

很棒

纯度: 99.43%

货号 T0268 别名 盐酸洛贝林, α-Lobeline hydrochloride, L-Lobeline hydrochlorideCas号 134-63-4

Lobeline hydrochloride (α-Lobeline hydrochloride) 是一种烟碱样受体激动剂，是神经元烟碱受体α3β2和α4β2拮抗剂。

规格	价格	库存
5 mg	¥ 127	现货
10 mg	¥ 181	现货
25 mg	¥ 280	现货
50 mg	¥ 400	待询
100 mg	¥ 696	待询

库存状态实时更新，以官网显示为准，现货产品可直接加购物车下单

大包装 & 定制

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TargetMol的所有产品仅用作科学研究或药证申报，不能被用于人体，我们不向个人提供产品和服务。请您遵守承诺用途，不得违反法律法规规定用于任何其他用途。

实验操作小课堂

常见问题解答

选择批次:

纯度: 99.43%

颜色: 白色

性状: Solid

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资源下载:

COA HPLC HNMR 产品操作手册

产品介绍

Lobeline hydrochloride AI Summary

Lobeline hydrochloride exhibits a broad spectrum of bioactivities against various biological targets. It shows antiplasmodial activity against multiple strains of Plasmodium falciparum, with IC50 values ranging from 3981.07 nM to 15848.93 nM after 72 hours, as measured by the SYBR green assay. The compound is active in several assays, acting as an inhibitor of mitochondrial division, activator of mitochondrial fusion, and inhibitor of Schistosoma Mansoni Peroxiredoxins. It also demonstrates efficacy against Hepatitis C Virus (HCV) and Marburg Virus, and exhibits delayed death inhibition of the malarial parasite plastid. In addition, Lobeline hydrochloride inhibits a wide range of enzymatic and protein interactions, including endonuclease IV, MPP8 Chromodomain, Histone Lysine Methyltransferase G9a, HP1-beta Chromodomain, Polymerase Iota, Human hERG Channel activity, and USP1/UAF1, with potencies ranging from 22.4 nM to 89125.1 nM. The compound shows inhibition of electric eel AChE at 2 mg/ml with a rate of -0.17% and of horse BChE at 2 mg/ml with a 30.37% rate. Additionally, Lobeline hydrochloride significantly inhibits sodium fluorescein uptake in OATP1B3- and OATP1B1-transfected CHO cells at a concentration of 10 µM, with inhibition percentages of 108.46% and 125.57%, respectively. Its antiviral activity is noted against SARS-CoV-2, reducing virus-induced cytotoxicity in Caco-2 and VERO-6 cells at a concentration of 10 µM with varying inhibition rates. Specifically, it showed 24.02% inhibition in Caco-2 cells after 48 hours and -0.02% in VERO-6 cells. Additionally, it inhibits SARS-CoV-2 3CL-Pro protease with an inhibition percentage of 0.3163% at 20 µM. Lobeline hydrochloride also demonstrates moderate antifungal activity against Candida albicans and various antibacterial activities with notable inhibition rates against Klebsiella pneumoniae, Pseudomonas aeruginosa, Acinetobacter baumannii, and Staphylococcus aureus MRSA. Its impact on cell viability varies across different cell lines, showing both cytotoxic and stimulatory properties in HEK293T, U2OS, and human fibroblast cells. Overall, Lobeline hydrochloride proves to be a versatile compound with diverse biological activities ranging from antiplasmodial and antiviral efficacy to inhibition of various enzymatic processes and cellular growth effects..

Note: Summary generated by AI. Data source: ChEMBL

生物活性

产品描述	Lobeline hydrochloride (α-Lobeline hydrochloride) is a nicotinic receptor agonist, acting as an effective antagonist at both α4β2 and α3β2 neuronal nicotinic receptor subtypes.
别名	盐酸洛贝林, α-Lobeline hydrochloride, L-Lobeline hydrochloride

化学信息

分子量	373.92
分子式	C₂₂H₂₇NO₂·HCl
CAS No.	134-63-4
Smiles	Cl.CN1[C@H](C[C@H](O)c2ccccc2)CCC[C@@H]1CC(=O)c1ccccc1
密度	no data available

储存&溶解度

存储

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

溶解度信息

DMSO: 45 mg/mL (120.35 mM), Sonication is recommended.

溶液配制表

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.6744 mL	13.3718 mL	26.7437 mL	133.7184 mL
5 mM	0.5349 mL	2.6744 mL	5.3487 mL	26.7437 mL
10 mM	0.2674 mL	1.3372 mL	2.6744 mL	13.3718 mL
20 mM	0.1337 mL	0.6686 mL	1.3372 mL	6.6859 mL
50 mM	0.0535 mL	0.2674 mL	0.5349 mL	2.6744 mL
100 mM	0.0267 mL	0.1337 mL	0.2674 mL	1.3372 mL

计算器

摩尔浓度计算器
稀释计算器
配液计算器
分子量计算器

体内实验配液计算器

请在以下方框中输入您的动物实验信息后点击计算，可以得到母液配置方法和体内配方的制备方法：

比如您的给药剂量是10 mg/kg，每只动物体重20 g，给药体积100 μL，一共给药动物10只，您使用的配方为 10% DMSO + 40% PEG300 + 5% Tween 80 + 45% Saline / PBS / ddH₂O，那么您的工作液浓度为2 mg/mL。

母液配置方法：2 mg 药物溶于 100 μL DMSO （母液浓度为 20 mg/mL ）, 如您需要配置的浓度超过该产品的溶解度，请先与我们联系。

体内配方的制备方法： 取 100 μL DMSO 母液，添加 400 μL PEG300 混匀澄清，再加 50 μL Tween 80, 混匀澄清, 再加 450 μL Saline / PBS / ddH₂O 混匀澄清

以上为“体内实验配液计算器”的使用方法举例，并不是具体某个化合物的推荐配制方式，请根据您的实验动物和给药方式选择适当的溶解方案。

方案所需的各类助溶剂如： DMSO， PEG300， PEG400， Tween 80， SBE-β-CD，玉米油等，均可在TargetMol网站点击购买。

剂量转换

对于不同动物的给药剂量换算，您也可以参考更多

关键词

α-Lobeline Nicotinic Receptor nAChR Lobeline L-Lobeline alpha-Lobeline Hydrochloride a-Lobeline Hydrochloride

Lobeline hydrochloride

Lobeline hydrochloride